Hypoxia stimulates human preproendothelin-1 promoter activity in transgenic mice

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 273, Issue 4 17-4, 1997, Pages

  Aversa, Catherine R ^a   Oparil, Suzanne ^b   Caro, Jaime ^c   Li, Huaibin ^b   Sun, Shuang Dan ^b   Chen, Yiu Fai ^b   Swerdel, Mavis R ^a   Monticello, Thomas M ^a   Durham, Stephen K ^a   Minchenko, Alexander ^c   Lira, Sergio A ^a   Webb, Maria L ^a,d  

^a BRISTOL MYERS SQUIBB   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d PHARMACOPEIA INC   (United States)

Author keywords

Endothelin; Heart failure; Pulmonary hypertension

Indexed keywords

ENDOTHELIN 1; LUCIFERASE; PREPROENDOTHELIN 1; UNCLASSIFIED DRUG;

ARTICLE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; LUNG BLOOD VESSEL; LUNG PARENCHYMA; OXYGEN TENSION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; REGULATORY MECHANISM;

EID: 0030708739     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.273.4.l848     Document Type: Article

References (17)

1. Beck, I., S. Ramirez, R. Weinmann, and J. Caro. Enhancer element at the 3′-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene. J. Biol. Chem. 266: 15563-15566, 1991.
2. Bird, J. E., M. L. Webb, M. M. Asaad, M. R. Giancarli, C. C. Chao, and C. R. Dorso. A role for endothelin-A receptors in maintenance of renal function in spontaneously hypertensive rats. Eur. J. Pharmacol. 294: 183-189, 1995.
3. Bloch, K. D., S. P. Friedrich, M.-E. Lee, R. L. Eddy, T. B. Shows, and T. Quertermous. Structural organization and chromosomal assignment of the gene encoding endothelin. J. Biol. Chem. 264: 10851-10857, 1989.
4. Cacoub, P., R. Dorent, P. Nataf, A. Carayon, G. Maistre, J. C. Piette, P. Godeau, C. Cabrol, and I. Gandjbakhach. Plasma endothelin and pulmonary pressures in patients with congestive heart failure. Am. Heart J. 126: 1484-1488, 1993.
5. Cernacek, P., and D. J. Stewart. Immunoreactive endothelin in human plasma: marked elevations in patients with cardiogenic shock. Biochem. Biophys. Pes. Commun. 161: 562-567, 1989.
6. Chen, M., K. Todd-Turla, W.-H. Wang, X. Cao, A. Smart, F. C. Brosius, P. D. Killen, J. A. Keiser, J. P. Briggs, and J. Schnermann. Endothelin-1 mRNAin glomerular and epithelial cells of kidney. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol. 34): F542-F550, 1993.
7. Douglas, S. A., C. Louden, L. M. Vickery-Clarke, B. L. Storer, T. Hart, G. Z. Feurstein, J. D. Elliot, and E. H. Ohlstein. A role for endogenous endothelin-1 in neointimal formation after rat carotid artery balloon angioplasty. Protective effects of the novel nonpeptide endothlin receptor antagonist SB 209670. Circ. Res. 75: 190-197, 1994.
8. Elton, T. S., S. Oparil, G. R. Taylor, P. H. Hicks, R.-H. Yang, H. Jin, and Y. F. Chen. Normobaric hypoxia stimulates endothelin-1 gene expression in the rat. Am. J. Physiol. 263 (Regulatory Integrative Comp. Physiol. 32): R1260-R1264, 1993.
9. Ferrer, P., M. Valentine, T. Jenkins-West, H. Weber, N. L. Goller, S. K. Durham, C. J. Molloy, and S. Moreland. An orally-active endothelin receptor antagonist suppresses neointimal development in balloon-injured rat carotid arteries. J. Cardiovasc. Pharmacol. 26908-26915, 1995.
10. Giaid, A., M. Yanagisawa, D. Langleben, R. P. Michael, R. Levy, H. Shennib, S. Kimura, T. Masaki, P. Duguid, F. R. C. Path, and D. J. Stewart. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N. Engl. J. Med. 328: 1732-1739, 1993.
11. Goldberg, M. A., and T. J. Schneider. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial cell growth factor and erythropoietin. J. Biol. Chem. 269: 4355-4359, 1994.
12. Greenstein-Baynash, A., K. Hosoda, A. Giaid, J. A. Richardson, N. Emoto, R. E. Hammer, and M. Yanagisawa. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell 79: 1277-1285, 1994.
13. Grover, G. J., S. Dwonczyk, and C. S. Parham. The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion. Cardiovasc. Res. 27: 1613-1618, 1993.
14. Grover, G. J., P. G. Sleph, M. Fox, and N. C. Trippodo. Role of endothelin-1 in modulating coronary vascular tone, contractile function and severity of ischemia in rat hearts. J. Pharmacol. Exp. Ther. 263: 1074-1082, 1992.
15. Harats, D., H. Kurihara, P. Belloni, H. Oakley, A. Ziober, D. Ackley, G. Cain, Y. Kurihara, R. Lawn, and E. Sigal. Targeting gene expression to the vascular wall in transgenic mice using the murine preproendothelin-1 promoter. J. Clin. Invest. 95: 1335-1344, 1995.
16. Hilkert, R. J., S. de la Monte, M.-E. Lee, J. S. Yun, T. E. Wagner, and T. Quertermous. Transgene expression directed by the endothelin-1 promoter is cell-type-specific but integration-site-dependent. J. Vasc. Med, Biol. 4: 138-147, 1993.
17. Hosoda, K., R. E. Hammer, J. A. Richardson, A. Greenstein Baynash, J. C. Cheung, A. Giaid, and M. Yanagisawa. Targeted and natural (Piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 79: 1267-1276, 1994.