Properties of circulating IgA molecules in Henoch-Schonlein purpura nephritis with focus on neutrophil cytoplasmic antigen IgA binding (IgA-ANCA): New insight into a debated issue

Nephrology Dialysis Transplantation

Volumn 12, Issue 11, 1997, Pages 2269-2276

  Coppo, R ^a   Cirina, P ^a   Amore, A ^a   Sinico, R A ^b   Radice, A ^b   Rollino, C ^c  

^a REGINA MARGHERITA CHILDREN S HOSPITAL   (Italy)

^b SAN CARLO BORROMEO HOSPITAL   (Italy)

^c S GIOVANNI BOSCO HOSPITAL   (Italy)

Author keywords

ANCA; Henoch Schonlein purpura; IgA glycosylation; IgA ANCA; Lectins

Indexed keywords

GALACTOSE; IMMUNOGLOBULIN A; JACALIN; MYELOPEROXIDASE; N ACETYLGLUCOSAMINE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PROTEINASE;

ADOLESCENT; ADULT; ANAPHYLACTOID PURPURA; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CHILD; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; KIDNEY BIOPSY; MAJOR CLINICAL STUDY; NEPHRITIS; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; BLOTTING, WESTERN; CHILD; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOGLOBULIN A; NEPHRITIS; PEROXIDASE; PURPURA, SCHOENLEIN-HENOCH;

EID: 0030707477     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/12.11.2269     Document Type: Article

References (26)

1. Coppo R, Mazzucco G, Cagnoli L, Lupo A, Schena FP for the Italian Group of renal Immunopathology. Long-term prognosis of Henoch-Schönlein purpura nephritis in adults and children. Nephrol Dial Transplant (in press)
2. Van der Wall Bake AWL, Lobatto S, Jonges L, Daha MR, van Es LA. IgA antibodies directed against cytoplasmic antigens of polymorphonuclear leukocytes in patients with Henoch Schoenlein purpura. Adv Exp Med Biol 1987; 216: 1593-1598
3. Rollino C, Roccatello D, Coppo R et al. Classic and perinuclear anti-neutrophil cytoplasm antibodies and antimyeloperoxidase antibodies in rapidly progressive glomerulonephritis. Am J Nephrol 1991; 11: 318-324
4. Coppo R, Sardella M, Porcellini MG et al. IgA-ANCA in children with Henoch-Schoenlein and primary IgA nephropathy. J Am Soc Nephrol 1992; 3: 652
5. O'Donoghue DJ, Nusbaum P, Noel LH, Halbwachs-Mecarelli L, Lesavre P. Antineutrophil cytoplasmic antibodies in IgA nephropathy and Henoch-Schönlein purpura. Nephrol Dial Transplant 1992; 7: 534-538
6. Shaw G, Ronda N, Bevan LS, Esnault V, Griffiths DFR, Rees A, Antineutrophil cytoplasmic antibodies (ANCA) of IgA class correlate with disease activity in adult Henoch-Schönlein purpura. Nephrol Dial Transplant 1992; 7: 1238-1241
7. Lin JJ, Stewart CL, Kaskel FJ, Fine R. IgG and IgA classes of anti-neutrophil cytoplasmic autoantibodies in a 13-year-old girl with recurrent Henoch-Schoenlein purpura. Pediatr Nephrol 1993; 7: 143-146
8. Ronda N, Esnault VLM, Layward L, Sepe V, Allen A, Feehally J. Antineutrophil cytoplasm antibodies (ANCA) of IgA isotype in adult Henoch-Schoenlein purpura. Clin Exp Immunol 1994; 95: 49-55
9. Sinico RA, Tadros M, Radice A et al. Lack of IgA antineutrophil cytoplasmic antibodies in Henoch-Schoenlein purpura and IgA nephropathy. Clin Immunol Immunopathol 1994; 73: 19-26
10. Falk R, Jenette J. Anti-neutrophil cytoplasmic autoantibodies with specificity for myeloperoxidase in patients with systemic vasculitis and idiopathic necrotizing and crescentic glomerulonephritis. N Engl J Med 1988; 318: 1651-1655
11. Falk R. ANCA-associated renal disease. Kidney Int 1990; 38: 998-1010
12. Coppo R, Amore A, Gianoglio B et al. Macromolecular IgA and abnormal IgA reactivity in sera from children with IgA nephropathy. Clin Nephrol 1995; 43: 1-13
13. Roque Barreira MC, Campos-Neto A. Jacalin, an IgA-binding lectin. J Immunol 1985; 134: 1740-1743
14. Sinico RA, Fornasieri A, Oreni N, Benuzzi S, D'Amico G. Polymeric IgA rheumatoid factor in idiopathic IgA mesangial nephropathy (Berger's disease). J Immunol 1986; 137: 536-541
15. Laemli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T 4. Nature 1970; 227: 680-685
16. Knight JF. The rheumatic poison: a survey of some published investigations of the immunopathogenesis of Henoch-Schoenlein purpura. Pediatr Nephrol 1990; 4: 533-541
17. Davin JC, Foidart J, Mahieu PR. Relation between biological IgA abnormalities and mesangial IgA deposits in isolated hematuria in childhood. Clin Nephrol 1987; 28: 73-80
18. Kallenberg CGM, Brouwer E, Weening JJ, Cohen Tervaert JW. Anti-neutrophil cytoplasmic antibodies: current diagnostic and pathophysiological potential. Kidney Int 1994; 46: 1-15
19. Kallenberg CGM, Brouwer E, Mulder AHL, Stegeman CA, Weening JJ, Cohen Tervaert JW. ANCA-pathophysiology revisited. Clin Exp Immunol 1995; 100: 1-3
20. Davin JC, Li Vecchi M, Nagy J et al. Evidence that the interaction between circulating IgA and fibronectin is a normal process enhanced in primary IgA nephropathy. J Clin Immunol 1991; 2: 78-94
21. Mestecky J, Tomana M, Crowley-Nowick PA, Moldoveanu Z, Julian BA, Jackson S. Defective galactosylation and clearance of IgA1 molecules as a possible etiopathogenic factor in IgA nephropathy. Contrib Nephrol 1993; 104: 172-182
22. Coppo R, Amore A, Roccatello D et al. IgA to dietary proteins and IgA-lectin binding in sera from Italian, Australian and Japanese IgA nephropathy patients. Am J Kidney Dis 1991; 4: 480-487
23. Hiki Y, Horii A, Iwase H et al. O-linked oligosaccharide on IgA1 hinge region in IgA nephropathy. Fundamental study for precise structure and possible role. Contrib Nephrol 1994; 11: 73-84
24. Allen AC, Harper SJ, Feehally J. Galactosylation of N- and O-linked carbohydrate moieties of IgA1 and IgG in IgA nephropathy. Clin Exp Immunol 1995; 100: 470-474
25. Kerr A. The structure and function of human IgA. Biochem J 1990; 271: 283-296
26. Rifai A, Chen A, Imai H. Complement activation in experimental IgA nephropathy: an antigen-mediated process. Kidney Int 1987; 32: 838-845