Is there evidence for neuronal loss in schizophrenia?

International Review of Psychiatry

Volumn 9, Issue 4, 1997, Pages 429-436

  Benes, Francine M ^a  

^a MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPSY; BRAIN CORTEX; BRAIN REGION; CELL COUNT; HIPPOCAMPUS; HISTOPATHOLOGY; HUMAN; LIMBIC SYSTEM; MOTOR CORTEX; NERVE CELL; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA;

EID: 0030704240     PISSN: 09540261     EISSN: None     Source Type: Journal    
DOI: 10.1080/09540269775295     Document Type: Review

References (39)

1. ABERCROMBIE, M. (1946). Estimation of nuclear population from microtomic sections. Anatomical Review, 94, 239.
2. AKBARIAN, S., KIM, J. J., POTKIN, S. G., HAGMAN, J. O., TAFAZZOLI, A., BUNNEY, W. E. & JONES, E. G. (1995). Gene expression for glutamatic acid decarboxylase is reduced without loss of neurons in prefrontal cortex of schizophrenics. Archives of General Psychiatry, 52, 258-278.
3. ARNOLD, S. E., FRANZ, B. R., GUR, R. C., GUR, R. E., SHAPIRO, R. M., MOBERG, P. J. & TOJANOWSKI, J. Q. (1995). Smaller neuron size in schizophrenia in hippocampal subfields that mediate cortical hippocampal interactions. American Journal of Psychiatry, 152, 738-748.
4. BENES, F. M. (1988). Post-mortem structural analyses of schizophrenic brain: study designs and the interpretation of data. Psychiatric Developments, 6, 213-266.
5. BENES, F. M. (1993). Post-mortem correlates of brain imaging findings in schizophrenia. Harvard Review of Psychiatry, 1, 100-109.
6. BENES, F. M. (1995). Is there a neuroanatomic basis to schizophrenia? An old question revisited. The Neuroscientist, 1, 104-115.
7. BENES, F. M., DAVIDSON J. & BIRD E. D. (1986). Quantitative cytoarchitectural studies of cerebral cortex of schizophrenics. Archives of General Psychiatry, 43, 31-35.
8. BENES, F. M., SORENSEN I. & BIRD, E. D. (1991a). Morphometric analyses of the hippocampal formation in schizophrenic brain. Schizophrenia Bulletin, 17, 597-608.
9. BENES, F. M., MCSPARREN, J., BIRD, E. D., VINCENT, S. L. & SAN GIOVANNI, J. P. (1991b). Deficits in small interneurons in prefrontal and anterior cingulate cortex of schizophrenic and schizoaffective patients. Archives of General Psychiatry 48, 996-1001.
10. BENES, F. M., VINCENT, S. L., ALSTERBERG, G., BIRD, E. D. & SAN GIOVANNI, J. P. (1992). Increased GABA-A receptor binding in superficial layers of cingulate cortex in schizophrenics. Journal of Neuroscience, 12, 924-929.
11. BENES, F. M., KWOK, E. & VINCENT, S. L. (1996). Relative distribution of pyramidal (PN) and non-pyramidal (NP) neurons in the hippocampus of schizophrenic (SZ) and manic depressive (MD) brain. Society for Neuroscience, 22, 1.
12. BENES, F. M., TODTENKOPF, M. S. & TAYLOR, J. B. (1997). Differential distribution of tyrosine hydroxylase fibers on neuronal subtypes in anterior cingulate cortex of schizophrenic brain. Synapse, 25, 80-92.
13. BOGERTS, B., MEERTZ, E. & SCHONFELD-BAUSCH, R. (1985). Basal ganglia and limbic system pathology in schizophrenia: a morphometric study of brain volume and shrinkage. Archives of General Psychiatry, 42, 784-791.
14. BROWN, R., COLTER, N., CORSELLIS, J, A. N., CROW, T. J., FRITH, C. D., JAGOE, R., JOHNSTONE, E. C. & MARSH, L. (1986). Post-mortem evidence for structural brain changes in schizophrenia. Differences in brain weight, temporal horn area and parahippocampal gyrus width as compared with affective disorder. Archives of General Psychiatry, 43, 36-42.
15. CARLSSON, A. (1978). Mechanism of action of neuroleptic drugs. In: M. A. LIPTON, A. DIMASCIO & K. F. KILLAM (Eds), Psychopharmacology: a generation of progress (pp. 1057-1070). New York: Raven Press.
16. COGGESHALL, R. E. & LEKAN, H. A. (1996). Methods for determining numbers of cell and synapses: a case for more uniform standards of review. Journal of Comparative Neurology, 364, 6-15.
17. COLON, E. J. (1971). Quantitative cytoarchitectonics of the human cerebral cortex. Psychiatria, Neurologia, Neurochirurgia, 74, 291-302.
18. DELAY, J. & DENIKER, P. (1952). Trente-huit cas de psychoses traitee par la cure prolongee et continue de 4500 R.P. In: LE CONGRES DES et al. (Eds), Neurologie. Paris, De Langue France: Mason et Cie.
19. DOM, R. (1976). Neostriatal and thalamic interneurons. Their role in the pathophysiology of Huntington's chorea, Parkinson's disease and catatonic schizophrenia. Acta Psychiatrica Scandinavica, 265 (suppl.), 103-123.
20. FALKAI, P. & BOGERTS, B. (1986). Cell loss in the hippocampus of schizophrenics. European Archives of Psychiatric & Neurological Science, 236, 154-161.
21. FALKAI, P., BOGERTS, B. & ROZUMEK, M. (1988). Cell loss and volume reduction in the entorhinal cortex of schizophrenics. Biological Psychiatry, 24, 515-521.
22. GUNDERSON, H. J. G., BAGGER, P., BENDTSEN, T. F., EVANS, S. M., KORBO, L., MARCUSSEN, N., MOLLER, A., NIELSEN, K., NYENGAARD, J. R., PAKKENBERG, B. et al. (1988). The new stereological tools: dissector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. Acta Pathologica, Methodologica & Immunologica Science, 96, 857-881.
23. HAUG, J. O. (1962). Pneumoencephalographic studies in mental disease. Acta Psychiatrica Scandinavica, 38, 65-85.
24. HECKERS, S., HEINEN, H., GEIGER, B. & BECKMANN, H. (1991). Hippocampal neuron number in schizophrenia. Archives of General Psychiatry, 48, 1002-1008.
25. HECKERS, S., HEINSEN, H., HEINSEN, Y. & BECKMANN, H. (1990). Limbic structures and lateral ventricle in schizophrenia. Archives of General Psychiatry, 47, 1016-1022.
26. JACOBSEN, B. & KINNEY, D. K. (1980). Perinatal complications in adopted and non-adopted schizophrenics and their controls: preliminary results. Acta Psychiatrica Scandinavica, 238, 103-123.
27. JAKOB, H. & BECKMAN, H. (1986). Prenatal development. I. Disturbances in the limbic allocortex in schizophrenics. Journal of Neural Transmission, 65, 303-326.
28. JESTE, D. & LOHR, J. B. (19). Hippocampal pathologic findings in schizophrenia. Archives of General Psychiatry, 46, 1019-1024.
29. PAKKENBERG, B. (1990). Pronounced reduction of total neuron number in mediodorsal thalamic nucleus and nucleus accumbens in schizophrenics. Archives of General Psychiatry, 47, 1023-1028.
30. PAKKENBERG, B. (1993). Total nerve cell numbers in neocortex in chronic schizophrenics and controls estimated using optical dissectors. Biological Psychiatry, 34, 7.
31. PARNAS, J., SCHULSINGER, F., TEASDALE, W., SCHULSINGER, H., FELDMAN, P. M. & MEDNICK, S. A. (1982). Perinatal complications and clinical outcome. British Journal of Psychiatry, 140, 416-420.
32. ROBERTS, G. W., COLTER, N., LOFTHOUSE, R., BOGERTS, B., ZEC, M. & CROW, T. J. (1986). Gliosis in schizophrenia. A survey. Biological Psychiatry, 39, 1043-1050.
33. SAPER, C. B. (1996). Any way you cut it: a new journal policy for the use of unbiased counting methods. Journal of Comparative Neurology, 364, 5.
34. SELEMON, L. D., RAJKOWSKA, G. & GOLDMAN-RAKIC, P. S. (1995). Abnormally high neuronal density in the schizophrenic cortex: a morphometric analysis of prefrontal area 9 and occipital area 17. Archives of General Psychiatry, 52, 805-818.
35. STEVENS, J. R. (1973). An anatomy of schizophrenia? General Archives of Psychiatry, 29, 177-189.
36. VONSATTEL, J. P. G., AIZAWA, H., GE, P., DIFIGLIA, M., MCKEE, A. C., MACDONALD, M., GUSELLA, J. F., LANDWEHRMEYER, G. B., BIRD, E. D., RICHARDSON, E. P. & HEDLLEY-WHITE, E. T. (1995). An improved approach to prepare human brains for research. Journal of Neuropathology and Experimental Neurology, 54, 42-56.
37. WEIBEL, E. R. (1979). Elementary introduction to stereological principles. Stereological methods (volume 1) (pp. 46-57). New York: Academic Press.
38. WILLIAMS, R. W. & RAKIC, P. (1988). Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. Journal of Comparative Neurology, 278, 344-352.
39. WINDLE, W. F. & BECKER, R. F. (1944). Alterations in brain structure after asphyxiation at birth. Journal of Neuropathology and Experimental Neurology, 3, 224-238.