Loss of heterozygosity studies and deletion mapping identify two putative chromosome 14q tumor suppressor loci in renal oncocytomas

Cancer Research

Volumn 57, Issue 22, 1997, Pages 5009-5012

  Schwerdtle, Rüdiger F ^a   Winterpacht, Andreas ^a   Störkel, Stephan ^b   Brenner, Walburgis ^a   Hohenfellner, Rudolf ^a   Zabel, Bernhard ^a   Huber, Christoph ^a   Decker, Hans Jochen ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME DELETION; CHROMOSOME MAP; CONTROLLED STUDY; GENE FREQUENCY; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; KIDNEY CARCINOMA; ONCOCYTOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ADENOMA, OXYPHILIC; ADULT; AGED; AGED, 80 AND OVER; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 14; FEMALE; GENE DELETION; GENES, TUMOR SUPPRESSOR; HUMANS; KIDNEY NEOPLASMS; LOSS OF HETEROZYGOSITY; MALE; MICROSATELLITE REPEATS; MIDDLE AGED;

EID: 0030703621     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Thoenes, W., Störkel, S., and Rumpelt, H. J. Histopathology and classification of renal cell tumors (adenomas, oncocytomas, and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol. Res. Pract., 181: 125-143, 1986.
2. Psihramis, K. E., Dal Cin, P., Dretler, S. P., Prout, G. R., Jr., and Sandberg, A. A. Further evidence that renal oncocytoma has malignant potential. J. Urol., 139: 585-587, 1988.
3. Brown, J. A., Takahashi, S., Alcaraz, A., Borell, T. J., Anderl, K. L., Qian, J., Persons, D. L., Bostwick, D. G., Lieber, M. M., and Jenkins, R. B. Fluorescence in situ hybridization analysis of renal oncocytoma reveals frequent loss of chromosomes Y and 1. J. Urol., 156: 31-35, 1996.
4. Crotty, T. B., Lawrence, K. M., Moertel, C. A., Bartelt, D. H., Batts, K. P., Dewald, G. W., Farrow, G. M., and Jenkins, R. B. Cytogenetic analysis of six oncocytomas and a chromphobe cell renal carcinoma. Evidence that -Y, -1 may be a characteristic anomaly in renal oncocytomas. Cancer Genet. Cytogenet., 61: 61-66, 1992.
5. Neuhaus, C., Dijkhuizen, T., van den Berg, E., Störkel, S., Stöckle, M., Mensch, B., Huber, C., and Decker, H. J. Involvement of the chromosomal region 11q13 in renal oncocytoma: case report and literature review. Cancer Genet. Cytogenet., 94: 95-98, 1997.
6. Störkel, S. Carcinomas and oncocytomas of the kidney. Phenotypical characteristics and prognostic aspects. Stuttgart, Germany: Gustav Fischer Verlag, 1993.
7. Tallini, G., Ladanyi, M., Rosai, J., and Jhanwar, S. C. Analysis of nuclear and mitochondrial DNA alterations in thyroid and renal oncocytic tumors. Cytogenet. Cell Genet., 66: 253-259, 1994.
8. Noguchi, S., Nagashima, Y., Shuin, T., Kubota, Y., Kitamura, H., Yao, M., and Hosaka, M. Renal oncocytoma containing "chromophobe" cells. Int. J. Urol., 2: 279-280, 1995.
9. Kovacs, A., Störkel, S., Thoenes, W., and Kovacs, G. Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas. J. Pathol., 167: 273-277, 1992.
10. Welter, C., Kovacs, G., Seitz, G., and Blin, N. Alteration of mitochondrial DNA in human oncocytomas. Genes Chromosomes Cancer, 1: 79-82, 1989.
11. Schwerdtle, R. F., Störkel, S., Neuhaus, C., Brauch, H., Weidt, E., Brenner, W., Hohenfellner, R., Huber, C., and Decker, H. J. Allelic losses at chromosomes 1p, 2p, 6p, 10p, 13q, 17p, and 21q significantly correlate with the chromophobe subtype of renal cell carcinoma. Cancer Res., 56: 2927-2930, 1996.
12. Koreth, J., O'Leary, J. J., and McGee, J. O. Microsatellites and PCR genomic analysis. J. Pathol., 178: 239-24, 1996.
13. Schwengel, D. A., Jedlicka, A. E., Nanthakumar, E. J., Weber, J. L., and Levitt, R. C. Comparison of fluorescence-based semi-automated genotyping of multiple microsatellite loci with autoradiographic techniques. Genomics, 22: 46-54, 1994.
14. Decker, H. J., Gemmill, R. M., Neumann, H. P., Walter, T. A., and Sandberg, A. A. Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome. Cancer Genet. Cytogenet., 39: 289-293, 1989.
15. Pandit, S. D., Wang, J. C., Veile, R. A., Mishra, S. K., Warlick, C. A., and Donis-Keller, H. Index, comprehensive microsatellite, and unified linkage maps of human chromosome 14 with cytogenetic tie points and a telomere microsatellite marker. Genomics, 29: 653-664, 1995.
16. Gruis, N. A., Abeln, E. C., Bardoel, A. F., Devilee, P., Frants, R. R., and Cornelisse, C. J. PCR-based microsatellite polymorphisms in the detection of loss of heterozygosity in fresh and archival tumour tissue. Br. J. Cancer, 68: 308-313, 1993.
17. Cairns, P., Tokino, K., Eby, Y., and Sidransky, D. Homozygous deletions of 9p21 in primary human bladder tumors detected by comparative multiplex polymerase chain reaction. Cancer Res., 54: 1422-1424, 1994.
18. Speicher, M. R., Schoell, B., du Manoir, S., Schrock, E., Ried, T., Cremer, T., Störkel, S., Kovacs, A., and Kovacs, G. Specific loss of chromosomes 1, 2, 6, 10, 13, 17, and 21 in chromophobe renal cell carcinomas revealed by comparative genomic hybridization. Am. J. Pathol., 145: 356-364, 1994.
19. Polascik, T. J., Cairns, P., Epstein, J. I., Fuzesi, L., Ro, J. Y., Marshall, F. F., Sidransky, D., and Schoenberg, M. Distal nephron renal tumors: microsatellite allelotype. Cancer Res., 56: 1892-1895, 1996.
20. Thrash-Bingham, C. A., Salazar, H., Greenberg, R. E., and Tartof, K. D. Loss of heterozygosity studies indicate that chromosome arm 1p harbors a tumor suppressor gene for renal oncocytomas. Genes Chromosomes Cancer, 16: 64-67, 1996.
21. Thrash-Bingham, C. A., Salazar, H., Freed, J. J., Greenberg, R. E., and Tartof, K. D. Genomic alterations and instabilities in renal cell carcinomas and their relationship to tumor pathology. Cancer Res., 55: 6189-6195, 1995.
22. Brauch, H., Tory, K., Linehan, W. M., Weaver, D. J., Lovell, M. A., and Zbar, B. Molecular analysis of the short arm of chromosome 3 in five renal oncocytomas. J. Urol., 143: 622-624, 1990.
23. Wu, S. Q., Hafez, G. R., Xing, W., Newton, M., Chen, X. R., Messing, E., and Xing, W. R. The correlation between the loss of chromosome 14q with histologic tumor grade, pathologic stage, and outcome of patients with nonpapillary renal cell carcinoma. Cancer (Phila.), 77: 1154-1160, 1996.
24. Young, J., Leggett, B., Ward, M., Thomas, L., Buttenshaw, R., Searle, J., and Chenevix Trench, G. Frequent loss of heterozygosity on chromosome 14 occurs in advanced colorectal carcinomas. Oncogene, 8: 671-675, 1993.
25. Simon, M., von Deimling, A., Larson, J. J., Wellenreuther, R., Kaskel, P., Waha, A., Warnick, R. E., Tew, J. M., Jr., and Menon, A. G. Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression. Cancer Res., 55: 4696-4701, 1995.
26. Chang, W. Y., Cairns, P., Schoenberg, M. P., Polascik, T. J., and Sidransky, D. Novel suppressor loci on chromosome 14q in primary bladder cancer. Cancer Res., 55: 3246-3249, 1995.
27. Bandera, C. A., Takahashi, A., Behbakht, K., Liu, P. C., Livolsi, V. A., Benjamin, I., Morgan, M. A., King, S. A., Rubin, S. C., and Boyd, J. Deletion mapping of two potential chromosome 14 tumor suppressor gene loci in ovarian carcinoma. Cancer Res., 57: 513-515, 1997.