Synthesis, preliminary evaluation and molecular modeling studies of new, conformationally constrained analogues of the competitive NMDA receptor antagonist 4-(phosphonomethyl)-2-piperidinecarboxylic acid (CGS 19755)

Farmaco

Volumn 52, Issue 6-7, 1997, Pages 477-486

  Pellicciari, R ^a   Marinozzi, M ^a   Natalini, B ^a   Costantino, G ^a   Lankin, D C ^a   Snyder, J P ^a   Monahan, J B ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHOSPHONOMETHYLPIPECOLIC ACID; 7 CARBOXY 8 AZASPIRO[4,5]DECANE 1 PHOSPHONIC ACID; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; BINDING SITE; DRUG SYNTHESIS; ISOMER; MOLECULAR MODEL; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE;

BINDING SITES; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPECOLIC ACIDS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030701640     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)