Regional differences in calcium sensitivity in the guinea-pig intestine

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 10, 1997, Pages 981-984

  Okamoto, Hiroki ^a,b   Inoue, Kimihiro ^a   Kamisaki, Toshiaki ^a   Takahashi, Kazuyoshi ^a   Sato, Makoto ^a  

^a Research Laboratories   (Japan)

^b SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ATROPINE; CADMIUM; CALCIUM CHANNEL; CALCIUM ION; CLONIDINE; NICARDIPINE; NICKEL; TETRODOTOXIN; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; ASCENDING COLON; CALCIUM TRANSPORT; CONTROLLED STUDY; CULTURE MEDIUM; DESCENDING COLON; DUODENUM; EXTRACELLULAR FLUID; GUINEA PIG; ILEUM; INTESTINE MUSCLE; JEJUNUM; MALE; NONHUMAN; RECTUM; SMOOTH MUSCLE TONE;

EID: 0030701534     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06027.x     Document Type: Article

References (14)

1. Arruebo, M. P., Alcalde, A. I., Murillo, M. D. (1987) Mucosal-free ruminai circular smooth muscle response to transmural electrical stimulation. J. Vet. Pharmacol. Ther. 10: 349-350
2. Barone, F. C., White, R. F., Ormsbee, H. S., Wasserman, M. A. (1986) Effects of calcium channel entry blockers, nifedipine and nilvadipine, on colonic motor activity. J. Pharmacol. Exp. Ther. 237: 99-106
3. Gurney, A. M. (1994) Mechanisms of drug-induced vasodilation. J. Pharm. Pharmacol. 46: 242-251
4. Johns, A. J., Leijten, P., Yamamoto, H., Hwang, K., Van Breeman, C. (1987) Calcium regulation in vascular smooth muscle contractility. Am. J. Cardiol. 59: 18A
5. Krevsky, B., Maurer, A. H., Niewiarowski, T., Cohen, S. (1991) Effect of verapamil on human intestinal transit. Dig. Dis. Sci. 37: 919-924
6. 2+-channel blockers in inhibiting muscular and nerve activities in isolated colon. Br. J. Pharmacol. 102: 735-741
7. Litchfield Jr, J. T., Wilcoxon, F. (1949) A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96: 99-113
8. Maggi, C. A., Manzini, S., Meli, A. (1985) Regional selectivity of calcium blockers at intestinal level. Arch. Int. Pharmacodyn. 276: 202-221
9. Manzini, S., Maggi, C., Meli, A. (1984) System and organ selectivity of smooth muscle relaxants on in vitro spontaneously contracting preparations. Arch. Int. Pharmacodyn. 270: 50-60
10. 2+-antagonist inhibition of intestinal motor activity. Pharmacol. Res. 21: 119-121
11. Marino, F., Marcoli, M., Ponti, F. D., Cosentino, M., Lecchini, S., Frigo, G. M. (1994) Effect of desipramine-induced blockade of neuronal uptake mechanisms on adrenoceptor-mediated responses in the guinea-pig colon. Naunyn Schmiedebergs Arch. Pharmacol. 350: 499-506
12. 2+ antagonists on spontaneous motility from sheep duodenum. J. Pharm. Pharmacol. 46: 138-140
13. Nyska, A., Waner, T., Galiano, A., Fich, A. (1994) Constipation and megacolon in rats related to treatment with oxodipine, a calcium antagonist. Toxicol. Pathol. 22: 589-594
14. Snape, W. J. (1982) Effect of calcium on neurohumoral stimulation of feline colonic smooth muscle. Am. J. Physiol. 243: G134-G140