Numerical chromosomal aberrations in borderline, benign, and malignant epithelial tumors of the ovary: Correlation with p53 protein overexpression and Ki-67

Journal of the Society for Gynecologic Investigation

Volumn 4, Issue 5, 1997, Pages 262-264

  Kohlberger, P D ^a   Kieback, D G ^b   Mian, C ^c   Wiener, H ^c   Kainz, Ch ^a   Gitsch, G ^a   Breitenecker, G ^c  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF VIENNA   (Austria)

Author keywords

Borderline tumors of the ovary; FISH; Immunohistochemistry; Numerical chromosomal aberrations

Indexed keywords

KI 67 ANTIGEN; PROTEIN P53;

ADULT; AGED; ARTICLE; CANCER STAGING; CHROMOSOME 12; CHROMOSOME 17; CHROMOSOME 7; CHROMOSOME ABERRATION; CLINICAL ARTICLE; DISEASE SEVERITY; EPITHELIUM TUMOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALIGNANT TRANSFORMATION; OVARY TUMOR; PRIORITY JOURNAL;

ADULT; AGED; CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 12; CHROMOSOMES, HUMAN, PAIR 17; CHROMOSOMES, HUMAN, PAIR 7; FEMALE; GENES, P53; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; KI-67 ANTIGEN; MIDDLE AGED; OVARIAN NEOPLASMS; TRISOMY; UP-REGULATION;

EID: 0030700806     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(97)00061-0     Document Type: Article

References (17)

1. Silva EG, Kurman RJ, Russell P, Scully RE. Symposium Ovarian tumors of borderline malignancy . Int J Gynecol Pathol. 15:1996;281-302.
2. Serov SF, Scully RE, Sobin LH. International histologic classification of tumours. Vol. 9. Histological typing of ovarian tumours. 1973;World Health Organization, Geneva.
3. Hart WR, Norris HJ. Borderline and malignant tumors of the ovary. Cancer. 31:1973;1031-1045.
4. Bell DA, Scully RE. Ovarian serous borderline tumors with stromal microinvasion A report of 21 cases . Hum Pathol. 21:1990;397-403.
5. Hopkins MP, Kumar NB, Morley GW. An assessment of pathologic features and treatment modalities in ovarian tumors of low malignant potential. Obstet Gynecol. 70:1987;923-929.
6. Chambers JT, Merino MJ, Kohorn EI, Schwartz PE. Borderline ovarian tumors. Am J Obstet Gynecol. 159:1988;1088-1094.
7. Pinkel D, Straume T, Gray JW. Cytogenetic analysis using quantitative, high sensitivity fluorescence hybridisation. Proc Natl Acad Sci USA. 83:1986;2934-2938.
8. Wertheim I, Muto MG, Welch WR, Bell DA, Berkowitz RS, Mok SC. P53 gene mutation in human borderline epithelial ovarian tumors. J Natl Cancer Inst. 86:1994;1549-1550.
9. Berchuck A, Kohler MF, Hopkins MP, et al. Overexpression of P53 is not a feature of benign and early-stage borderline epithelial ovarian tumors. Gynecol Oncol. 52:1994;232-236.
10. Kupryjanczyk J, Bell DA, Yandell DW, Scully RE, Thor AD. P53 expression in ovarian borderline tumors and stage I carcinomas. Am J Clin Pathol. 102:1994;671-676.
11. Isola J, Kallioniemi OP, Korte JM, et al. Steroid receptors and Ki-67 reactivity in ovarian cancer and in normal ovary Correlation with DNA flow cytometry, biochemical receptor assay and patient survival . J Pathol. 162:1990;295-301.
12. Henriksen R, Strang P, Wilander E, Bäckström T, Tribukait B, Öberg K. p53 expression in epithelial ovarian neoplasms Relationship to clinical and pathological parameters, Ki-67 expression and flow cytometry . Gynecol Oncol. 53:1994;301-306.
13. Gallion HH, Powell DE, Smith LW, et al. Chromosome abnormalities in human epithelial ovarian malignancies. Gynecol Oncol. 38:1990;473-477.
14. Persons DL, Hartmann LC, Herath JF, Keeney GL, Jenkins RB. Fluorescence in situ hybridization analysis of trisomy 12 in ovarian tumors. Am J Clin Pathol. 102:1994;775-779.
15. Shashi V, Golden WL, von Kap-Herr C, Andersen WA, Gaffey MJ. Interphase fluorescence in situ hybridization for trisomy 12 on archival ovarian sex cord-stromal tumors. Gynecol Oncol. 55:1994;349-354.
16. Halperin D, Visscher DW, Wallis T, Lawrence D. Evaluation of chromosome 12 copy number in ovarian granulosa cell tumors using interphase cytogenetics. Int J Gynecol Pathol. 14:1995;319-323.
17. Runnebaum IB, Kieback DG, Möbus VJ, Tong XW, Kreienberg R. Subcellular localization of accumulated p53 in ovarian cancer cells. Gynecol Oncol. 61:1996;266-271.