Effect of indomethacin and N(ω)-nitro-L-arginine methyl ester on the pressure/flow relation in isolated perfused hindlimbs from pregnant and nonpregnant rats

Journal of the Society for Gynecologic Investigation

Volumn 4, Issue 5, 1997, Pages 229-235

  Ahokas, Robert A ^a   Friedman, Steven A ^a   Sibai, Baha M ^a  

^a Dept Obstet Gynecol Univ T   (United States)

Author keywords

Nitric oxide; Perfused hindlimb; Pregnancy; Prostaglandin; Vascular conductance

Indexed keywords

INDOMETACIN; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NORADRENALIN; PROSTACYCLIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOWMETRY; FEMALE; LIMB PERFUSION; MEMBRANE CONDUCTANCE; NONHUMAN; PREGNANCY; PRESSURE MEASUREMENT; PRIORITY JOURNAL; RAT; VASCULAR ENDOTHELIUM; VASODILATATION;

ANIMALS; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; HINDLIMB; INDOMETHACIN; NG-NITROARGININE METHYL ESTER; PERFUSION; PREGNANCY; RATS; RATS, INBRED WKY; VASCULAR RESISTANCE;

EID: 0030700804     PISSN: 10715576     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1071-5576(97)00046-4     Document Type: Article

References (38)

1. Ryan US, Rubanyi GM. Endothelial regulation of vascular tone. 1992;Marcel Dekker, New York.
2. + current in vascular endothelial cells. Nature. 331:1988;168-170.
3. Cooke JP, Rossitch E Jr, Andon NA, Loscalzo J, Dzau VJ. Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J Clin Invest. 88:1991;1663-1671.
4. Rubanyi GM, Romero JC, Vanhoutte PM. Flow-induced release of endothelium-derived relaxing factor. Am J Physiol. 250:1986;H1145-H1149.
5. Rubanyi GM, Freay AD, Kauser K, Johns A, Harder DR. Mechanoreception by the endothelium mediators and mechanisms of pressure- and flow-induced vascular responses . Blood Vessels. 27:1990;246-257.
6. Griffith TM, Edwards DH, Davies RL, Harrison TJ, Evans KT. EDRF coordinates the behavior of vascular resistance vessels. Nature. 329:1987;442-445.
7. Pohl U, Herlan K, Huang A, Bassenge E. EDRF-mediated shear-induced dilation opposes myogenic vasoconstriction in small rabbit arteries. Am J Physiol. 261:1991;H2016-H2023.
8. Clark SL, Cotton DB, Lee W, et al. Central hemodynamics of normal term pregnancy. Am J Obstet Gynecol. 161:1989;1439-1442.
9. Gilson GC, Mosher MD, Conrad KP. Systemic hemodynamics and oxygen transport during pregnancy in chronically instrumented rats. Am J Physiol. 263:1992;H1911-H1918.
10. Roberts JM, Taylor RN, Musci TJ, et al. Preeclampsia an endothelial cell disorder . Am J Obstet Gynecol. 161:1989;1200-1204.
11. Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens. 4:1991;700-708.
12. deGroot CJM, Taylor RN. New insights into the etiology of pre-eclampsia. Ann Med. 25:1993;243-249.
13. Ahokas RA, Sibai BM. Endothelium-derived relaxing factor inhibition augments vascular angiotensin II reactivity in the pregnant rat hindlimb. Am J Obstet Gynecol. 167:1992;1053-1058.
14. Schretzenmayer A. Über kreislaufregulatorische vorgäange an den großen arterien bei der muskelarbeit. Pflügers Arch Ges Physiol. 232:1933;743-748.
15. Smiesko V, Lang DJ, Dolezel S. Role of endothelium in the control of arterial diameter by blood flow. Blood Vessels. 22:1985;247-251.
16. Pohl U, Holtz J, Busse R, Bassenge E. Crucial role of endothelium in the vasodilator response to increased flow in vivo. Hypertension. 8:1986;37-44.
17. Hull SS, Kaiser L, Jaffe MD, Sparks HV. Endothelium-dependent, flow-induced dilation of canine femoral and saphenous arteries. Blood Vessels. 23:1986;183-198.
18. Kuo L, Davis MJ, Chilian WM. Endothelium-dependent, flow-induced dilation of isolated coronary arterioles. Am J Physiol. 259:1990;H1063-H1070.
19. Smiesko V, Lang DJ, Johnson PC. Dilator response of rat mesenteric cascading arterioles to increased blood flow velocity. Am J Physiol. 257:1989;H1958-H1965.
20. Koller A, Kaley G. Endothelium regulates skeletal muscle circulation by a blood flow velocity-sensing mechanism. Am J Physiol. 258:1990;H916-H920.
21. Buga GM, Gold ME, Fukuto GI, Ignarro LJ. Shear stress-induced release of nitric oxide from endothelial cells grown on beads. Hypertension. 17:1991;187-193.
22. Kanai AJ, Strauss HC, Truskey GA, Crews AL, Gruenfeld S, Malinski T. Shear stress induces ATP-independent transient nitric oxide release from vascular endothelial cells, measured directly with a porphyrinic microsensor. Circ Res. 77:1995;284-293.
23. Melkumyants AM, Balashov SA, Kartamyshev SP. Anticonstrictor effect of endothelium sensitivity to shear stress. Pflügers Arch. 427:1994;264-269.
24. Juncos LA, Garvin J, Carretero OA, Ito S. Flow modulates myogenic responses in isolated microperfused rabbit afferent arterioles via endothelium-derived nitric oxide. J Clin Invest. 95:1995;2741-2748.
25. Humphreys PW, Joels N. The responses of the hindlimb vascular bed of the rabbit to sympathetic stimulation and its modification by pregnancy. J Physiol. 330:1982;475-488.
26. Conrad KP, Joffe GM, Kruszna H, et al. Identification of increased nitric oxide biosynthesis during pregnancy in rats. FASEB J. 7:1993;566-571.
27. Ahokas RA, Sibai BM. Enhanced endothelium-derived relaxing factor activity in pregnant, spontaneously hypertensive rats. Am J Obstet Gynecol. 165:1991;801-807.
28. ω-nitro-L-arginine, an inhibitor of nitric oxide synthesis, increases blood pressure in rats and reverses the pregnancy-induced refractoriness to vasopressor agents. Am J Obstet Gynecol. 166:1992;1560-1567.
29. Nathan L, Cuevas J, Chaudhuri G. The role of nitric oxide in the altered vascular reactivity of pregnancy in the rat. Br J Pharmacol. 114:1995;955-960.
30. McLaughlin MK, Griggs K, Crandell ME. Pregnancy enhances endothelium-dependent relaxation. Thirty-sixth annual meeting of the Society for Gynecologic Investigation, San Diego, March 1989;180:171.
31. Weiner C, Martinez E, Zhu LK, Ghodi A, Chestnut D. In vitro release of endothelium-derived relaxing factor by acetylcholine is increased during guinea pig pregnancy. Am J Obstet Gynecol. 161:1989;1599-1605.
32. Kim TH, Weiner CP, Thompson LP. Effect of pregnancy on contraction and endothelium-mediated relaxation of renal and mesenteric arteries. Am J Physiol. 267:1994;H41-H47.
33. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric oxide synthases by sex hormones. Proc Natl Acad Sci USA. 91:1994;5212-5216.
34. Goetz RM, Morano I, Calovini T, Studer R, Holtz J. Increased expression of endothelial constitutive nitric oxide synthase in rat aorta during pregnancy. Biochem Biophys Res Commun. 205:1994;905-910.
35. Hishikawa K, Nakaki T, Marumo T, Suzuki H, Kato R, Saruta T. Up-regulation of nitric oxide synthase by estradiol in human aortic endothelial cells. FEBS Lett. 360:1995;291-293.
36. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol. 269:1995;H550-H555.
37. Masaaki U, Ohara Y, Navas JP, Nishida K, Murphy TJ, Alexander RW, et al. Regulation of endothelial cell nitric oxide synthase mRNA expression by shear stress. Am J Physiol. 269:1995;C1371-C1378.
38. Noris M, Morigi M, Donadelli R, et al. Nitric oxide synthesis by cultured endothelial cells is modulated by flow conditions. Circ Res. 76:1995;536-543.