Quantification of mutagenic/carcinogenic heterocyclic amines, MeIQx, Trp-P-1, Trp-P-2 and PhIP, contributing highly to genotoxicity of river water

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 393, Issue 1-2, 1997, Pages 73-79

  Ohe, Takeshi ^a  

^a KYOTO WOMEN'S UNIVERSITY   (Japan)

Author keywords

Blue rayon; Genotoxicity; Heterocyclic amine; MeIQx; PhIP; River water; Trp P 1; Trp P 2; umu Test

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; 3 AMINO 1 METHYL 5H PYRIDO[4,3 B]INDOLE; 3 AMINO 1,4 DIMETHYL 5H PYRIDO[4,3 B]INDOLE; HETEROCYCLIC AMINE; RIVER WATER;

ARTICLE; GENOTOXICITY; NONHUMAN; PRIORITY JOURNAL;

AMINES; ANIMALS; CARBOLINES; CARCINOGENS; CELLULOSE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FRESH WATER; IMIDAZOLES; JAPAN; MUTAGENICITY TESTS; MUTAGENS; QUINOXALINES; RATS; SALMONELLA TYPHIMURIUM; WATER POLLUTANTS, CHEMICAL;

EID: 0030699458     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00087-9     Document Type: Article

References (24)

1. Van Kreijl C.F., Kool H.J., De Vries M., Van Kranen H.J., De Greef E. Mutagenic activity in the rivers Rhine and Meuse in the Netherlands. Sci. Tot. Environ. 15:1980;137-147.
2. Galassi S., Guzzella J.B., Mingazzini M., Vigano L., Capri S., Sora S. Toxicological and chemical characterization of organic micropollutants in river Po waters (Italy). Water Res. 26:1992;19-27.
3. Grifoll M., Solanas A.M., Bayona J.M. Bioassay-directed chemical characterization of genotoxic agents in the dissolved and particulate water phases of the Besos and Llobregat Rivers (Barcelona, Spain). Arch. Environ. Contam. Toxicol. 23:1992;19-25.
4. Hashizume T., Ueda K., Tokusu S., Hanawa I., Kinae N. Monitoring of mutagens in river and marine sediments by Salmonella/microsome assay combined with blue cotton method. Bull. Environ. Contam. Toxicol. 49:1992;497-503.
5. Vargas V.M.F., Motta V.E.P., Henriques J.A.P. Mutagenic activity detected by the Ames test in river water under the influence of petro-chemical industries. Mutation Res. 319:1993;31-45.
6. Kusamran W., Wakabayashi K., Oguri A., Tepsuwan A., Nagao M., Sugimura T. Mutagenicities of Bangkok and Tokyo river waters. Mutation Res. 325:1994;99-104.
7. Sakamoto H., Ohe T., Hayatsu T., Hayatsu H. Evaluation of blue-chitin column, blue-rayon hanging, and XAD-resin column techniques for concentrating mutagens from two Japanese rivers. Mutation Res. 371:1996;79-85.
8. Maruoka S., Yamanaka S. Mutagenicity in Salmonella typhimurium tester strains of XAD-2 ether extract recovered from Katsura River water in Kyoto City and its fractions. Mutation Res. 102:1982;13-16.
9. Maruoka S., Yamanaka S., Yamamoto Y. Mutagenic activity in organic concentrate from Nishitakase River water in Kyoto City, and its fractions separated by using liquid-liquid fractionation and thin layer chromatography. Water Res. 19:1985;249-256.
10. Sakamoto H., Hayatsu H. A simple method for monitoring mutagenicity of river water. Mutagens in Yodo River systems Kyoto-Osaka. Bull. Environ. Contam. Toxicol. 44:1990;521-528.
11. Nakamuro K., Ueno H., Sayato Y. Evaluation of mutagenicity of municipal river water concentrated using XAD resin column method. Water Sci. Technol. 25:1992;293-299.
12. Sayato Y., Nakamuro K., Ueno H., Goto R. Mutagenicity of adsorbates to a copper-phthalocyanine derivative recovered from municipal river water. Mutation Res. 242:1990;313-317.
13. Ohe T. Evaluation of SOS-inducing activity with an O-acetyl transferase-overexpressing strain Salmonella typhimurium NM2009 for municipal river water and the identification of 1-nitropyrene. Water Sci. Technol. 33:1996;313-320.
14. Sayato Y., Nakamuro K., Ueno H., Goto R. Identification of polycyclic aromatic hydrocarbons in mutagenic adsorbates to a copper-phthalocyanine derivative recovered from municipal river water. Mutation Res. 300:1993;207-213.
15. Segawa T., Ueno H., Nakamuro K., Sayato Y. Behavior of Trp-P-2 during activated sludge process. Jap. J. Toxicol. Environ. Health. 39:1993;132-138.
16. Ono Y., Mohri S., Somiya I., Oda Y. Detection and evaluation of Trp-P-2 in biologically treated human feces and urine. Environ. Mutagen. Res. Commun. 17:1995;179-186.
17. Ono Y., Somiya I., Kawaguchi T. Genotoxicity of substances in the nightsoil and its biologically treated water. Water Res. 30:1996;569-577.
18. Ushiyama H., Wakabayashi K., Hirose M., Itoh H., Sugimura T., Nagao M. Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation. Carcinogenesis. 12:1991;1417-1422.
19. Wakabayashi K., Ushiyama H., Takahashi M., Nukaya H., Kim S.-B., Hirose M., Ochiai M., Sugimura T., Nagao M. Exposure to heterocyclic amines. Environ. Health Persp. 99:1993;129-133.
20. Murray S., Gooderham N.J., Boobis A.R., Davies D.S. Detection and measurement of MeIQx in human urine after ingestion of a cooked meat meal. Carcinogenesis. 10:1989;763-765.
21. Hayatsu H. Cellulose bearing covalently linked copper phthalocyanine trisulfonate as an adsorbent selective for polycyclic compounds and its use in studies of environmental mutagens and carcinogens. J. Chromatogr. 497:1992;37-56.
22. Oda Y., Yamazaki H., Watanabe M., Nohmi T., Shimada T. Development of high sensitive umu test system: rapid detection of genotoxicity of promutagenic aromatic amines by Salmonella typhimurium NM2009 possessing high O-acetyltransferase activity. Mutation Res. 334:1995;145-156.
23. Manabe S., Uchino E., Wada O. Carcinogenic tryptophan pyrolysis products in airborne particles and rain water. Mutation Res. 226:1989;215-221.
24. Mohri S., Somiya I., Ono Y. Risk assessment of genotoxic substances related to human diet in the water environment. J. Jap. Soc. Water Environ. 19:1996;847-854.