Increased prostaglandin H synthase-1 expression and activity level in stably Harvey-ras transfected C3H10T1/2 cells

Cancer Letters

Volumn 119, Issue 1, 1997, Pages 87-92

  Xu, Xianghong ^a   Burgess, John R ^a   Teegarden, Dorothy ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

Cyclooxygenase; PGH synthase; ras gene

Indexed keywords

MESSENGER RNA; PROSTAGLANDIN H; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSFECTION; MESENCHYME; MOUSE; NONHUMAN; ONCOGENE H RAS; PRIORITY JOURNAL;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CYCLOOXYGENASE 1; FIBROBLASTS; GENES, RAS; HUMANS; MICE; RNA, MESSENGER; TRANSFECTION;

EID: 0030698828     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(97)00260-7     Document Type: Article

References (20)

1. J. Leon, A. Pellicer, ras genes involvement in carcinogenesis: lessons from animal model systems, in: The ras Superfamily of GTPases. CRC Press, Boca Raton, FL, 1993.
2. H.R. Bourne, D.A. Sanders, F. McCormick, The GTPase superfamily: a conserved switch for diverse cell functions, Nature 348 (1990) 125-132.
3. A. Nakamura, T. Yamatani, T. Fujita, T. Chiba, Mechanism of inhibitory action of prostaglandins on the growth of human gastric carcinoma cell line KATO III, Gastroenterology 101 (1991) 910-918.
4. 2 in human and murine melanoma cells in culture, Cancer Res. 46 (1986) 1688-1693.
5. M.J. Thun, MM. Namboordiri, C.W. Heath, Aspirin use and reduced risk of colon cancer, N. Engl. J. Med. 325 (1991) 1593-1596.
6. B.S. Fletcher, D.A. Kujubu, D.M. Perrin, H.R. Herschman, Structure of the mitogen-inducible TIS10 gene and demonstration that the TISO-encoded protein is a functional prostaglandin G/H synthase, J. Biol. Chem. 267 (1992) 4338-4344.
7. C.D. Funk, L.B. Funk, M.E. Kennedy, A.S. Pong, G.A. Fitz-Gerald, Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment, FASEB J. 5 (1991) 2304-2312.
8. D.L. DeWitt, Prostaglandin endoperoxide synthase: Regulation of enzyme expression, Biochem. Biophys. Acta 1083 (1991) 121-134.
9. W.L. Smith, Prostanoid biosynthesis and mechanisms of action, Am. J. Physiol. 263 (1992) F181-F191.
10. T. Hla, K. Neilson, Human cyclooxygenase-2 cDNA, Proc. Natl. Acad. Sci. USA 89 (1992) 7384-7388.
11. W. Xie, J.G. Chipman, D.I. Robertson, R.L. Erikson, D.L. Simmons, Expression of mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing, Proc. Natl. Acad. Sci. USA 88 (1991) 2692-2696.
12. W.L. Smith, E.A. Meade, D.L. DeWitt, Interactions of PGH synthase isozymes-l and -2 with NSAIDs, in: Cellular Generation, Transport, and Effects of Eicosanoids New York Academy of Sciences, New York, 1994, pp. 50-57.
13. 2 function, Cancer Lett. 107 (1996) 59-64.
14. 2 is coupled to hormonally regulated release of arachidonic acid, Proc. Natl. Acad. Sci. USA 89 (1992) 6147-6151.
15. D. Teegarden, E.J. Taparowsky, C. Kent, Altered phosphatidylcholine metabolism in C3H10T1/2 cells transfected with the Harvey-ras oncogene, J. Biol. Chem. 265 (1990) 6042-6047.
16. J. Barnett, J. Chow, D. Ives, M. Chiou, R. Mackenzie, E. Osen, B. Nguyen, S. Tsing, C. Bach, J. Freire, H. Chan, E. Sigal, C. Ramesha, Purification, characterization and selective inhibition of human prostaglandin G/H synthase 1 and 2 expressed in the baculovirus system, Biochern. Biophys. Acta. 1209 (1994) 130-139.
17. J.C. Otto, D.L. DeWitt, W.L. Smith, N-glycosylation of prostaglandin endoperoxide synthase-1 and -2 and their orientation in the endoplasmic reticulum, J. Biol. Chem. 268 (1993) 18234-18242.
18. M. Goppelt-Struebe, Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression, Prostaglandins Leukotrienes Essential Fatty Acids 52 (1995) 213-222.
19. D.L. DeWitt, E.A. Meade, Serum and glucocorticoid regulation of gene transcription and expression of the prostaglandin H synthase-1 and prostaglandin H synthase-2 isozymes, Arch. Biochem. Biophys. 306 (1993) 94-102.
20. R.R. Gorman, M.J. Bienowski, A.H. Lin, Elevated prostaglandin H synthase gene expression in ras-transformed cells, Adv. Prostaglandin, Thromboxane, Leuk. Res. 21A (1991)73-76.