Clastogenic activity of integerrimine determined in mouse micronucleus assays

Brazilian Journal of Genetics

Volumn 20, Issue 3, 1997, Pages 405-409

  Gimmler Luz, Maria Clara ^a   Erdtmann, Bernardo ^a  

^a Instituto de Biociências   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CLASTOGEN; INTEGERRIMINE; PYRROLIZIDINE ALKALOID;

ANIMAL CELL; ARTICLE; BLOOD; BONE MARROW; CONTROLLED STUDY; ERYTHROCYTE; FEMALE; MALE; MICRONUCLEUS; MICRONUCLEUS TEST; MOUSE; NONHUMAN; STRUCTURAL CHROMOSOME ABERRATION;

ANIMALIA; SENECIO BRASILIENSIS;

EID: 0030698794     PISSN: 01008455     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0100-84551997000300008     Document Type: Article

References (21)

1. Chies, J.M. (1983). Ação mutagênica da integerrimina no sistema de pelos estaminais de Tradescantia e meristemas radiculares de Allium cepa. Master's thesis, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
2. Gimmler, M.C. and Nardi, N.B. (1982). Electrophoretic and cytological analysis of the regenerating liver in integerrimine-treated rats. Rev. Bras. Genet. 5: 111-120.
3. Gimmler-Luz, M.C., Marques, E.K. and Johnston, R.K. (1987). Action of the pyrrolizidine alkaloid integerrimine in inducing meiotic chromosome aberrations in male mice. Rev. Bras. Genet. 10: 31-41.
4. Gimmler-Luz, M.C., Erdtmann, B. and Balbueno, R.A. (1990). The effect of the pyrrolizidine alkaloid integerrimine on the chromosomes of mouse bone marrow cells. Mut. Res. 241: 297-304.
5. Hincks, J.R., Kim, H.-Y., Segall, H.J., Molyneux, R.J., Stermitz, F.R. and Coulombe Jr., R.A. (1991). DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: Structure-activity relationships. Toxicol. Appl. Pharmacol. 111: 90-98.
6. Klásek, A. (1973). The investigation of pyrrolizidine alkaloids at the Institute of Chemistry of the Medical Faculty, Palacky University in Olomouc. Acta Univ. Palackianae Olomucensis- Fac. Medicae. 65: 33-50.
7. Kliesch, U. and Adler, I.-D. (1992). Sex differences in micronucleus induction with hycanthone methanesulfonate in bone marrow cells of mice. Mut. Res. 283: 249-253.
8. Kvitko, K. and Gimmler, M.C. (1986). Effects of integerrimine on the implantation and intrauterine development of mice. Rev. Bras. Genet. 9: 439-451.
9. MacGregor, J.T., Wehr, C.M. and Gould, D.H. (1980). Clastogen-induced micronuclei in peripheral blood erythrocytes: the basis of an improved micronucleus test. Environ. Mutagen. 2: 509-514.
10. MacGregor, J.T., Wehr, C.M., Henika, P.R. and Shelby, M.D. (1990). The in vivo erythrocyte micronucleus test: measurement at steady state increases assay efficiency and permits integration with toxicity studies. Fund. Appl. Toxicol. 14: 513-522.
11. Mavournin, K.H., Blakey, D.H., Cimino, M.C., Salamone, M.F. and Heddle, J.A. (1990). The in vivo micronucleus assay in mammalian bone marrow and peripheral blood. A report of the US Environmental Protection Agency Gene-Tox Program. Mut. Res. 239: 29-80.
12. McLean, E.K. (1970). The toxic actions of pyrrolizidine (Senecio) alkaloids. Pharm. Rev. 22: 429-483.
13. Moraes, E.C.F. (1952). Contribuição ao estudo químicotoxicológico do Senecio brasiliensis Less. Associate Professor thesis, Faculdade de Farmácia e Odontologia da Universidade de São Paulo, São Paulo.
14. Motidome, M. and Ferreira, P.C. (1966). Alcalóides do Senecio brasiliensis Less. Rev. Fac. Farm. Bioq. de São Paulo 4: 13-44.
15. Nardi, N.B., Gimmler, M.C. and Leite, B.G. (1980). Antimitotic action of integerrimine in rats. Rev. Bras. Genet. 3: 387-393.
16. Paula-Ramos, A.L.L. and Marques, E.K. (1978). Mutagenic action of integerrimine, an alkaloid present in Senecio brasiliensis (Sprengel) Less., in Drosophila. Rev. Bras. Genet. 1: 279-287.
17. Paula-Ramos, A.L.L., Querol, C.B., Marques, E.K. and Henriques, J.A.P. (1991). Cytotoxic activation of pyrrolizidine alkaloid integerrimine in the yeast Saccharomyces is caused by repairable DNA damage. Rev. Bras. Genet. 14: 897-912.
18. Rocha, C.L.M.S. and Azevedo, J.L. (1986). Use of the meth G1 reversion system of Aspergillus nidulans for the detection of mutagenicity of the pyrrolizidine alkaloid integerrimine. Rev. Bras. Genet. 9: 393-405.
19. Salamone, M., Heddle, J., Stuart, E. and Katz, M. (1980). Towards an improved micronucleus test - studies on 3 model agents, mitomycin C, cyclophosphamide and dimethylbenzanthracene. Mut. Res. 74: 347-356.
20. Schlegel, R. and MacGregor, J.T. (1982). The persistence of micronuclei in peripheral blood erythrocytes: detection of chronic chromosome breakage in mice. Mut. Res. 104: 367-369.
21. Schmid, W. (1976). The micronucleus test for cytogenetic analysis. In: Chemical Mutagens (Hollaender, A., ed.). Vol. 4. Plenum Press, New York, pp. 31-53.