Cellular distribution of NMDA glutamate receptor subunit mRNAs in the human cerebellum

Neurobiology of Disease

Volumn 4, Issue 1, 1997, Pages 35-46

  Scherzer, Clemens R ^c   Landwehrmeyer, G Bernhard ^a   Kerner, Julie A ^c   Standaert, David G ^c   Hollingsworth, Zane R ^c   Daggett, Lorrie P ^b   Veliçelebi, Gönül ^b   Penney Jr , John B ^c   Young, Anne B ^c  

^a UNIVERSITY OF FREIBURG   (Germany)

^b MERCK RESEARCH LABORATORIES   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ADULT; ARTICLE; AUTORADIOGRAPHY; BRAIN ELECTROPHYSIOLOGY; CELLULAR DISTRIBUTION; CEREBELLUM; CLINICAL ARTICLE; FEMALE; GRANULE CELL; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; PURKINJE CELL; QUANTITATIVE DIAGNOSIS; RECEPTOR DENSITY; SIGNAL TRANSDUCTION;

EID: 0030698369     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.1997.0136     Document Type: Article

References (56)

1. Adams, S.-L., Foldes, R. L., & Kamboj, R. K. (1995) Human N-methyl-D-aspartate receptor modulatory subunit hNR3: Cloning and sequencing of the cDNA and primary structure of the protein. Biochim. Biophys. Acta 1260, 105-108.
2. Akazawa, C., Shigemoto, R., Bessho, Y., Nakanishi, S., & Mizuno, N. (1994) Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats. J. Comp. Neurol. 347, 150-160.
3. Akbarian, S., Sucher, N. J., Bradley, D., Tafazzoli, A., Trinh, D., Hetrick, W. P., Potkin, S. G., Sandman, C. A., Bunney, W. E. J., & Jones, E. G. (1996) Selective alterations in gene expression for NMDA receptor subunits in prefrontal cortex of schizophrenics. J. Neurosci. 16, 19-30.
4. Angerer, L. M., & Angerer, R. C. (1991) Localization of mRNAs by in situ hybridization. Methods Cell. Biol. 35, 37-71.
5. Barton, A. J. L., Pearson, R. C. A., Najlerahim, A., & Harrison, P. J. (1993) Pre-and postmortem influences on brain RNA. J. Neurochem. 61.
6. Bliss, T. V. P., & Collingridge, G. L. (1993) A synaptic model of memory: Long-term potentiation in the hippocampus. Nature 361, 31-39.
7. Böckers, T. M., Zimmer, M., Muller, A., Bergmann, M., Brose, N., & Kreutz, M. R. (1994) Expression of the NMDA R1 receptor in selected human brain regions. NeuroReport 5, 965-969.
8. Brose, N., Gasic, G. P., Vetter, D. E., Sullivan, J. M., & Heinemann, S. F. (1993) Protein chemical characterization and immunocytochemical localization of the NMDA receptor subunit NMDA R1. J. Biol. Chem. 268, 22663-22671.
9. Buller, A. L., Larson, H. C., Schneider, B. E., Beaton, J. A., Morrisett, R. A., & Monaghan, D. T. (1994) The molecular basis of NMDA receptor subtypes: Native receptor diversity is predicted by subunit composition. J. Neurosci. 14, 5471-5484.
10. Chazot, P. L., Coleman, S. K., Cik, M., & Stephenson, F. A. (1994) Molecular characterization of N-methyl-D-aspartate receptors expressed in mammalian cells yields evidence for the coexistence of three subunit types within a discrete receptor molecule. J. Biol. Chem. 269, 24403-24409.
11. Daggett, L. P., Sacaan, A. I., Akong, M., Rao, S. P., Hess, S. D., Liaw, C., Urrutia, A., Jachec, C., Ellis, S. B., Dreessen, J., Knöpfel, T., Landwehrmeyer, G. B., Testa, C. M., Young, A. B., Varney, M., Johnson, E. C., & Veliçelebi, G. (1995) Molecular and functional characterization of recombinant human metabotropic glutamate receptor subtype 5. Neuropharmacology 34, 871-886.
12. Dupont, J.-L., Fournier, E., Gardette, R., & Crepel, F. (1984) Effect of excitatory amino acids on Purkinje cell dendrites in cerebellar slices from normal and staggerer mice. Neuroscience 12, 613-619.
13. Dupont, J.-L., Gardette, R., & Crepel, F. (1987) Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids: An in vitro study. Dev. Brain Res. 34, 59-68.
14. Ebralidze, A. K., Rossi, D. J., Tonegawa, S., & Slater, N. T. (1996) Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene. J. Neurosci. 16, 5014-5025.
15. Edwards, F. A. (1995) LTP - A structural model to explain the inconsistencies. Trends Neurosci. 18, 250-255.
16. Farrant, M., & Cull-Candy, S. G. (1991) Excitatory amino acid receptor-channels in Purkinje cells in thin cerebellar slices. Proc. R. Soc. London B. 244, 179-184.
17. Farrant, M., Feldmeyer, D., Takahashi, T., & Cull-Candy, S. G. (1994) NMDA-receptor channel diversity in the developing cerebellum. Nature 368, 335-339.
18. Foldes, R. L., Adams, S.-L., Fantaske, R. P., & Kamboj, R. K. (1994) Human N-methyl-D-aspartate receptor modulatory subunit hNR2A: Cloning and sequencing of the cDNA and primary structure of the protein. Biochim. Biophys. Acta 1223, 155-159.
19. Garthwaite, G., Yamini, B.J., & Garthwaite, J. (1987) Selective loss of Purkinje and granule cell responsiveness to N-methyl-D-aspartate in rat cerebellum during development. Dev. Brain Res. 36, 288-292.
20. Garthwaite, J., & Beaumont, P. S. (1989) Excitatory amino acid receptors in the parallel fibre pathway in rat cerebellar slices. Neurosci. Lett. 107, 151-159.
21. Hess, S. D., Daggett, L. P., Crona, J., Deal, C., Lu, C.-C., Urrutia, A., Chavez-Noriega, L., Ellis, S. B., Johnson, E. C., & Veliçelebi, G. (1996) Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors. J. Pharm. Exp. Ther. 278, 808-816.
22. Hirano, T., & Hagiwara, S. (1988) Synaptic transmission between rat cerebellar granule and Purkinje cells in dissociated cell culture: Effects of excitatory-amino acid transmitter antagonists. Proc. Natl. Acad. Sci. USA 85, 934-938.
23. Hollmann, M., & Heinemann, S. (1994) Cloned glutamate receptors. Annu. Rev. Neurosci. 17, 31-108.
24. Ikeda, K., Nagasawa, M., Mori, H., Araki, K., Sakimura, K., Watanabe, M., Inoue, Y., & Mishina, M. (1992) Cloning and expression of the ∈4 subunit of the NMDA receptor channel. FEBS Lett. 313, 34-38.
25. Ishii, T., Moriyoshi, K., Sugihara, H., Sakurada, K., Kadotani, H., Yokoi, M., Akazawa, C., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1993) Molecular characterization of the family of the N-methyl-D-aspartate receptor subunits. J. Biol. Chem. 268, 2836-2843.
26. Jansen, K. L., Faull, R. L., & Dragunow, M. (1990) NMDA and kainic acid receptors have a complementary distribution to AMPA receptors in the human cerebellum. Brain Res. 532, 351-354.
27. Kaneko, T., Itoh, K., Sigemoto, R., & Mizuno, N. (1989) Glutamate-like immunoreactivity in the lower brain stem and cerebellum of the adult rat. Neuroscience 32, 79-98.
28. Karp, S. J., Masu, M., Eki, T., Ozawa, K., & Nakanishi, S. (1993) Molecular cloning and chromosomal localization of the key subunit of the human N-methyl-D-aspartate receptor. J. Biol. Chem. 268, 3728-1733.
29. Kohr, G., Eckardt, S., Luddens, H., Monyer, H., & Seeburg, P. H. (1994) NMDA receptor channels: Subunit-specific potentiation by reducing agents. Neuron 12, 1031-1040.
30. Krupa, M., & Crepel, F. (1989) Transient sensitivity of rat cerebellar Purkinje cells to N-methyl-D-aspartate during development: A voltage clamp study in in vitro slices. Eur. J. Neurosci. 2, 312-316.
31. Kutsuwada, T., Kashiwabuchi, H., Mori, H., Sakimura, K., Kushiya, E., Araki, K., Meguro, H., Masaki, H., Kumanishi, T., Arakawa, M., & Mishina, M. (1992) Molecular diversity of the NMDA receptor channel. Nature 358, 36-41.
32. Landwehrmeyer, G. B., Standaert, D. G., Testa, C. M., Penney, J. B., Jr., & Young, A. B. (1995) NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum. J. Neurosci. 15, 5297-5307.
33. Le Bourdellès, B., Wafford, K. A., Kemp, J. A., Marshall, G., Bain, C., Wilcox, A. S., Sikela, J. M., & Whiting, P. J. (1994) Cloning, functional coexpression, and pharmacological characterization of human cDNAs encoding NMDA receptor NR1 and NR2A subunits. J. Neurochem. 62, 2091-2098.
34. Llano, I., Marty, A., Armstrong, C. M., & Konnerth, A. (1991) Synaptic-and agonist-induced excitatory currents of Purkinje cells in rat cerebellar slices. J. Physiol. 434, 183-213.
35. Meguro, H., Mori, H., Araki, K., Kushiya, E., Kutsuwada, T., Yamazaki, M., Kumanishi, T., Arakawa, M., Sakimura, K., & Mishina, M. (1992) Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs. Nature 357, 70-74.
36. Monyer, H., Burnashev, N., Laurie, D. J., Sakmann, B., & Seeburg, P. H. (1994) Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12, 529-540.
37. Monyer, H., Sprengel, R., Schoepfer, R., Herb, A., Higuchi, M., Lomeli, H., Burnashev, N., Sakmann, B., & Seeburg, P. H. (1992) Heteromeric NMDA receptors: Molecular and functional distinction of subtypes. Science 256, 1217-1221.
38. Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) Molecular cloning and characterization of the rat NMDA receptor. Nature 354, 31-37.
39. Perkel, D. J., Hestrin, S., Sah, P., & Nicoll, R. A. (1990) Excitatory synaptic currents in Purkinje cells. Proc. R. Soc. London B. 241, 116-121.
40. Petralia, R. S., Wang, Y-X., & Wenthold, R. J. (1994a) The NMDA receptor subunits NR2A and NR2B show histological and ultrastructural localization patterns similar to those of NR1. J. Neurosci. 14, 6102-6120.
41. Petralia, R. S., Yokotani, N., & Wenthold, R. J. (1994b) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. J. Neurosci. 14, 667-696.
42. Planells-Cases, R., Sun, W., Ferrer-Montiel, A. V., & Montai, M. (1993) Molecular cloning, functional expression, and pharmacological characterization of an N-methyl-D-aspartate receptor subunit from human brain. Proc. Natl. Acad. Sci. USA 90, 5057-5061.
43. Price, R. H., Albin, R. L., Sakurai, S. Y., Polinsky, R. J., Penny, J. B., & Young, A. B. (1993) Cerebellar excitatory and inhibitory amino acid receptors in multiple system atrophy. Neurology 43, 1323-1328.
44. Rabacchi, S., Bailly, Y., Delhaye-Bouchaud, N., & Mariani, J. (1992) Involvement of the N-methyl-D-aspartate (NMDA) receptor in synapse elimination during cerebellar development. Science 256, 1823-1825.
45. Rosenmund, C., Legendre, P., & Westbrook, G. L. (1992) Expression of NMDA channels on cerebellar Purkinje cells acutely dissociated from newborn rats. J. Neurophysiol. 68, 1901-1905.
46. Rudolf, G. D., Cronin, C. A., Landwehrmeyer, G. B., Standaert, D. G., Penney, J. B., Jr., & Young, A. B. (1996) Expression of N-methyl-D-aspartate glutamate receptor subunits in the prefrontal cortex of the rat. Neuroscience 73, 417-427.
47. Sheng, M., Cummings, J., Roldan, L. A., Jan, Y. N., & Jan, L. Y. (1994) Changing subunit composition of heteromeric NMDA receptors during development of rat cortex. Nature 368, 144-147.
48. Standaert, D. G., Landwehrmeyer, G. B., Kerner, J. A., Penney, J. B., Jr., & Young, A. B. (1996) Expression of NMDAR2D glutamate receptor subunit mRNA in neurochemically identified interneurons in the rat neostriatum, neocortex and hippocampus. Mol. Brain Res. 42, 89-102.
49. Standaert, D. G., Testa, C. M., Young, A. B., & Penney, J. B., Jr. (1994) Organization of N-methyl-D-aspartate glutamate receptor gene expression in the basal ganglia of the rat. J. Comp. Neurol. 343, 1-16.
50. Testa, C. M., Standaert, D. G., Landwehrmeyer, G. B., Penny, J. B., Jr., & Young, A. B. (1995) Differential expression of mGluR5 metabotropic glutamate receptor mRNA by rat striatal neurons. J. Comp. Neurol. 354, 241-252.
51. Wafford, K. A., Bain, C. J., Le Bourdellès, B., Whitting, P. J., & Kemp, J. A. (1993) Preferential co-assembly of recombinant NMDA receptors composed of three different subunits. NeuroReport 4, 1347-1349.
52. Wang, Y. H., Bosy, T. Z., Yasuda, R. P., Grayson, D. R., Vicini, S., Pizzorusso, T., & Wolfe, B. B. (1995) Characterization of NMDA receptor subunit-specific antibodies: Distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum. J. Neurochem. 65, 176-83.
53. Watanabe, M., Mishina, M., & Inoue, Y. (1994) Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum. J. Comp. Neurol. 343, 513-519.
54. Yamakura, T., Mori, H., Masaki, H., Shimoji, K., & Mishina, M. (1993) Different sensitivities of NMDA receptor channel subtypes to non-competitive antagonists. NeuroReport 4, 687-690.
55. Yuzaki, M., Forrest, D., Verselis, L. M., Shaiu, C. S., Curran, T., & Connor, J. A. (1996) Functional NMDA receptors are transiently active and support the survival of Purkinje cells in culture. J. Neurosci. 16, 4651-4661.
56. Zukin, R. S., & Bennett, M. V. L. (1995) Alternatively spliced isoforms of the NMDAR1 receptor subunit. Trends Neurosci. 18, 306-313.