Gene therapy in hypertension: Adenovirus-mediated kallikrein gene delivery in hypertensive rats

Human Gene Therapy

Volumn 8, Issue 15, 1997, Pages 1753-1761

  Jin, Lan ^a   Zhang, Jenny J ^a   Chao, Lee ^a   Chao, Julie ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE; CYCLIC GMP; KALLIKREIN; MESSENGER RNA; VIRUS VECTOR;

ADENOVIRUS; ADRENAL GLAND; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIHYPERTENSIVE THERAPY; AORTA; ARTICLE; BLOOD LEVEL; BLOOD PRESSURE REGULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOMEGALOVIRUS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE TARGETING; GENE THERAPY; HYPERTENSION; IMMUNOREACTIVITY; INTRAVENOUS DRUG ADMINISTRATION; KALLIKREIN KININ SYSTEM; KALLIKREIN URINE LEVEL; KIDNEY; LIVER LEVEL; MALE; NONHUMAN; PROMOTER REGION; RAT; SPLEEN; SYSTOLIC BLOOD PRESSURE; TISSUE LEVEL; URINE LEVEL;

ADENOVIRIDAE; ANIMALIA; CYTOMEGALOVIRUS;

EID: 0030697269     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.15-1753     Document Type: Article

References (5)

1. ADER, J., TRAN-VAN, T., and PRADDAUDE, F. (1987). Reduced urinary kallikrein activity in rats developing spontaneous hypertension. Am. J. Physiol. 252, F964-F969.
2. BERRY, T.D., HASSTEDT, S.J., HUNT, S.C., WU, L.L., SMITH, J.B., ASH, K.O., KUIDA, H., and WILLIAMS, R.R. (1989). A gene for high urinary kallikrein may protect against hypertension in Utah kindreds. Hypertension. 13, 3-8.
3. BHOOLA, K.D., FIGUEROA, C.D., and WORTHY, K. (1992). Bioregulation of kinins: kallikreins, kininogens, and kininases. Pharmacol. Rev. 44, 1-80.
4. BROOKER, G., HARPER, J.F., TERASAKI, W.L., and MOYLAN, R.D. (1979). Radioimmunoassay of cyclic AMP and cyclic GMP. Advan. Cyclic Nucleotide Res. 10, 1-33.
5. CARRETERO, O.A., POLOMSKI, C., HAMPTON, A., and SCICLI, A.G. (1976). Urinary kallikrein, plasma renin and aldosterone in New Zealand genetically hypertensive (GH) rats. Clin. Exp. Pharmacol. Physiol. 3, 55-59.