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Volumn 7, Issue 22, 1997, Pages 2819-2824

Synthesis and SAR of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual histamine H1/tachykinin NK1 receptor antagonist activity

Author keywords

[No Author keywords available]

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; HISTAMINE H1 RECEPTOR ANTAGONIST; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PIPERIDINE DERIVATIVE;

EID: 0030695112     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(97)10097-X     Document Type: Article
Times cited : (13)

References (14)
  • 8
    • 0343294135 scopus 로고    scopus 로고
    • note
    • 1 receptor antagonists and the dependence of each of these activities on the absolute configuration at the pyrrolidine 3-position will be presented in future publications covering structurally related series of compounds.
  • 10
    • 0000414496 scopus 로고
    • Paquette, L. A., Ed.; John Wiley & Sons: New York
    • (a) Hughes, D. L. In Organic Reactions; Paquette, L. A., Ed.; John Wiley & Sons: New York, 1992, 42, 335.
    • (1992) Organic Reactions , vol.42 , pp. 335
    • Hughes, D.L.1
  • 12
    • 0343294134 scopus 로고    scopus 로고
    • For a detailed description of the biological assays used see ref 2
    • For a detailed description of the biological assays used see ref 2.
  • 13
    • 0342424528 scopus 로고    scopus 로고
    • All new compounds displayed spectra consistent with assigned structure and analytical data and are ≥95% pure by reverse-phase HPLC analysis
    • All new compounds displayed spectra consistent with assigned structure and analytical data and are ≥95% pure by reverse-phase HPLC analysis.
  • 14
    • 0342424529 scopus 로고    scopus 로고
    • Log P values were calculated using PCMODELS 4.41
    • Log P values were calculated using PCMODELS 4.41.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.