Failure of monochloroacetic acid and trichloroacetic acid administered in the drinking water to produce liver cancer in male F344/N rats

Journal of Toxicology and Environmental Health

Volumn 52, Issue 5, 1997, Pages 425-445

  DeAngelo, Anthony B ^a   Bernard Daniel, D ^b   Most, Bernard M ^c   Olson, Greg R ^d  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c ALION SCIENCE AND TECHNOLOGY   (United States)

^d Pathology Associates Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROACETIC ACID; DRINKING WATER; TRICHLOROACETIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; DISINFECTION; HISTOPATHOLOGY; LIVER CANCER; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT;

EID: 0030694391     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/00984109708984074     Document Type: Article

References (49)

1. Bhat, H. K., Kanz, M. F., Campbell, C. A., and Ansari, C. A. S. 1991. Ninety day toxicity study of chloroacetic acids in rats. Fundam. Appl. Toxicol. 17:240-253.
2. Bull, R. J., Sanchez, I. M., Nelson, M. A., Larson, J. L., and Lansing, A. J. 1990. Liver tumor induction in B6C3F1 mice by dichloroacetate and trichloroacetate. Toxicology 63:341-359.
3. Cadet, J., and Teoule, R. 1978. Comparative study of oxidation of nucleic acid components by hydroxyl radicals, singlet oxygen, and superoxide anion radicals. Photochem. Photobiol. 28:661-667.
4. Chang, L. W., Daniel, F. B., and DeAngelo, A. B. 1992. Analysis of DNA strand breaks induced in rodent liver in vivo, hepatocytes in primary culture, and a human cell line by chlorinated acetic acids and chlorinated acetaldehydes. Environ. Mol. Mutagen. 20:277-288.
5. Christian, R. J., Norwood, D. L., Millington, D. S., and Johnson, J. D. 1983. Identity and yields of major halogenated products of aquatic fulvic acid chlorination. Environ. Sci. Technol. 17:625-628.
6. Coleman, W. E., Lingg, R. D., Melton, R. G., and Kopfler, F. C. 1976. The occurrence of volatile organics in five drinking water supplies using gas chromatography/mass spectroscopy. In Identification and analysis of organic pollutants of water, ed. L. H. Keith, pp. 305-327. Ann Arbor, Ml: Ann Arbor Science.
7. Coleman, E. W., Munch, J. W., Kaylor, W. H., Streicher, R. P., Ringhand, H. P., and Meier, J. R. 1984. Gas chromatography/mass spectroscopy analysis of mutagenic extracts of aqueous chlorinated humic acid. A comparison of the byproducts of drinking water contaminants. Environ. Sci. Technol. 18:674-678.
8. Daniel, F. B., Robinson, M., Stober, J. A., Page, N. P., and Olson, G. R. 1991. Ninety-day toxicity study of sodium monochloroacetic acid in Sprague-Dawley rats. Toxicology 67:171-185.
9. Davis, M. E. 1990. Subacute toxicity of trichloroacetic acid in male and female rats. Toxicology 63:63-72.
10. DeAngelo, A. B., and Daniel, F. B. 1990. Comparative carcinogenicity of dichloroacetic (DCA) and trichloroacetic (TCA) acid in the male B6C3F1 mouse. Toxicologist 10:148.
11. DeAngelo, A. B., Daniel, F. B., McMillan, L., Wernsing, P., and Savage, R. E., Jr. 1989. Species and strain sensitivity to the induction of peroxisome proliferation by chloroacetic acids. Toxicol. Appl. Pharmacol. 101:285-298.
12. DeAngelo, A. B., Daniel, F. B., Stober, J. A., and Olson, C. R. 1991. The carcinogenicity of dichloroacetic acid in the male B6C3F1 mouse. Fundam. Appl. Toxicol. 16:337-347.
13. DeMarini, D. M., Perry, E., and Shelton, M. L. 1994. Dichloroacetic acid and related compounds: induction of prophage in E. coli and mutagenicity and mutation spectra in Salmonella TA100. Mutagenesis 9:429-437.
14. Dierczk, P. J. 1984. In vitro binding of acetic acid and its chlorinated derivates by the soluble glutathione-S-transferase from rat liver. Res. Commun. Chem. Pathol. Pharmacol. 44:327-330.
15. Fienberg, S. W. 1980. The analysis of cross-classified data. Cambridge, MA: MIT Press.
16. Fuhrman, F. A., Field, J., Wilson, R. FI., and DeEds, F. M. 1955. Monochloroacetate: Effects of chronic administration to rats on growth, activity and tissue metabolism and inhibitory effect in vitro compared with monoiodoacetate and monobromoacetate. Arch. Int. Pharmacodyn. 102:13-25.
17. Gosselin, R. E., Smith, R. P., and Flodge, H. C. 1984. Clinical toxicology of commercial products, 5th ed. Baltimore, MD: Williams & Wilkins.
18. Gride, W. 1968. Autoradiographic materials and procedures. In Autoradiographic techniques, pp. 14-33. Englewood Cliffs, NJ: Prentice Flail.
19. Harrington-Brock, K., Smith, T. W., Parker, L. M., and Moore, M. M. 1992. Genotoxic effects of by-products of the chlorination of drinking water. Environ. Mol. Mutagen. 19(suppl. 20):24.
20. Haseman, J. K, Fluff, J., and Boorman, G. A. 1984. Use of historical control data in carcinogenicity studies in rodents. Toxicol. Pathol. 12:126-135.
21. Hayes, F. D., Short, R. D., and Gibson, J. E. 1973. Differential toxicity of monochloroacetate, monofluoroacetate and monoiodoacetate in rats. Toxicol. Appl. Pharmacol. 26:93-102.
22. Herbert, V., Gardener, A., and Coleman, N. 1980. Mutagenicity of dichloroacetate, an ingredient of some formulations of pangamic acid (Trade-name "vitamin B15") Am. J. Clin. Nutr. 33:1179-1182.
23. Herren-Freund, S. L., Pereira, M. A., Khoury, M. D., and Olson, G. 1987. The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid in mouse liver. Toxicol. Appl. Pharmacol. 90:183-189.
24. Krasner, S. W., McGuire, M. J., Jacangelo, J. G., Patania, N. L., Reagan, K. M., and Aieta, E. M. 1989, The occurrence of disinfection by-products in U.S. drinking water. J. Am. Water Works Assoc. 81:41-53.
25. Larson, J. L., and Bull, R. J. 1992. Metabolism and lipoperoxidative activity of trichloroacetate and dichloroacetate in rats and mice. Toxicol. Appl. Pharmacol. 115:268-277.
26. Leblond, L., and Percival, W. L. 1948. Autoradiographic localization of radioiodine in the thyroid gland. Soc. Exp. Biol. Med. Proc. 67:74.
27. Liebler, D. C., Meredith, M. J., and Guengerich, F. P. 1985. Formation of glutathione conjugates by reactive metabolites of vinylidene chloride in microsomes and isolated hepatocytes. Cancer Res. 45:186-193.
28. Lowry, O. H., Rosebrough, J. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent./. Biol. Chem. 193:265-275.
29. Mather, G. G., Exon, J. H., and Koller, L. 1990. Subchronic 90 day toxicity of dichloroacetic acid and trichloroacetic acid in rats. Toxicology 64:71-80.
30. Mink, F. L., Coleman, W. E., Munch, J. W., Kaylor, W. H., and Ringhand, H. P. 1983. In vivo formation of halogenated reaction products following peroral sodium hypochlorite. Bull. Environ. Contam. Toxicol. 30:394-399.
31. National Institute of Environmental Health Sciences. 1995. Tumor Incidence in Control Animals by Route and Vehicle of Administration. F344/N Rat. Research Triangle Park, NC: NIEHS.
32. National Toxicology Program. 1992. Toxicity and Carcinogenesis Studies of Monochloroacetic Acid in F344/N rats and B6C3F1 Mice. NTP Technical Report 396. NIH Publication No. 90-2851. Washington, DC: NTP.
33. Osumi, T., and Hashimoto, T. 1978. Enhancement of fatty acyl-CoA oxidizing activity in rat liver peroxisomes by di(2-ethylhexyl)phthalate. J. Biochem. 83:1361-1365.
34. Parnell, M. J., Exon, J. H., and Koller, L. D. 1988. Assessment of hepatic initiation-promotion properties of trichloroacetic acid. Arch. Environ. Contam. Toxicol. 17:429-436.
35. Rannug, U., Cothe, R., and Wachtmeister, C. A. 1976. The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol, and chloroacetic acid, conceivable metabolites of vinyl chloride. Chem. Biol. Interact. 12:251-263.
36. Rapson, W. H., Nazar, M. A., and Butsky, V. V. 1980. Mutagenicity produced by aqueous chlorination of organic compounds. Bull. Environ. Contam. Toxicol. 24:590-597.
37. Reddy, J. K., Azarnoff, D. L., and Hignite, C. E. 1980. Hypolipidemic hepatic peroxisome prolif-erators form a novel class of chemical carcinogens. Nature 283:397-398.
38. Reichert, D., Werner, H. W., Metzler, M., and Henschler, D. 1979. Molecular mechanisms of 1,1-dichloroethylene toxicity: Excreted metabolites reveal different pathways of reactive intermediates. Arch. Toxicol. 42:159-169.
39. SAS Institute, Inc. 1989. SAS/STAT user's guide, version 6, 4th ed., vol. 2. Cary, NC: SAS Institute, Inc.
40. SAS Institute, Inc. 1990. SAS procedures guide, 3rd ed. Cary, NC: SAS Institute, Inc.
41. Stacpoole, P. W., Lorenz, A. C., Thomas, R. G., and Harman, E. M. 1988. Dichloroacetate in the treatment of lactic acidosis. Ann. Intern. Med. 108:58-63.
42. Styles, J. A., Wyatt, I., and Coutts, C. 1991. Trichloroacetic acid: Studies on uptake and effects on hepatic DNA and liver growth in mouse. Carcinogenesis 12:1715-1719.
43. Tarone, R. E., and Ware, J. 1977. On distribution-free tests for equality of survival distributions. Biometrika 64:156-169.
44. Uden, P. C., and Miller, J. W. 1983. Chlorinated acids and chloral in drinking water. J. Am. Water Works Assoc. 75:524-527.
45. Warner, H. R., Fernandes, G., and Wang, E. 1995. A unifying hypothesis to explain the retardation of aging and tumorigenesis by caloric restriction. J Cerontol. 50A:B107-B109.
46. Winer, B. 1971. Statistical principles in experimental design, pp. 337-347. New York: McGraw-Hill.
47. uC in the mouse. Acta Pharmacol. Toxicol. 30:257-265.
48. 4C in the mouse. Acta Pharmacol. Toxicol. 30:248-256.
49. Yllner, S. 1971c. Metabolism of chloroacetate in the mouse. Acta Pharmacol. Toxicol. 30:69-80.