Nitric oxide effects on cell growth: GMP-dependent stimulation of the AP-1 transcription complex and cyclic GMP-independent slowing of cell cycling

British Journal of Pharmacology

Volumn 122, Issue 4, 1997, Pages 687-697

  Sciorati, Clara ^a   Nisticò, Giuseppe ^b   Meldolesi, Jacopo ^a   Clementi, Emilio ^a,c,d  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY MEDITERRANEA OF REGGIO CALABRIA   (Italy)

^d SAN RAFFAELE HOSPITAL   (Italy)

Author keywords

Cell cycle; Cyclic GMP; EGF signalling; Nitric oxide

Indexed keywords

8 BROMO CYCLIC GMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; DEOXYRIBONUCLEOTIDE; DNA; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTATHIONE DERIVATIVE; GUANOSINE PHOSPHATE; GUANYLATE CYCLASE; HYDROXYUREA; ISOSORBIDE DINITRATE; LINSIDOMINE; MEVINOLIN; MIMOSINE; MITOGEN ACTIVATED PROTEIN KINASE; N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NOCODAZOLE; RIBONUCLEOTIDE REDUCTASE; STAUROSPORINE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL GROWTH; CELL STRAIN 3T3; COLORIMETRY; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME REGULATION; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

3T3 CELLS; ANIMALS; CELL CYCLE; CELL DIVISION; CYCLIC GMP; EPIDERMAL GROWTH FACTOR; HUMANS; MICE; NITRIC OXIDE; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

EID: 0030694068     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701413     Document Type: Article

References (51)

1. WAF/CIPI/SD11 is elevated through a p53-independent pathway by mimosine. Cell Growth Diff., 7, 893-901.
2. ANGEL, P. & KARIN, M. (1991). The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta, 1072, 129-157.
3. BAKER, T.L. & BUSS, J.E. (1996). Treatment of intact NIH 3T3 cells with nitric oxide affects proteins in the ras signaling pathway. In The Biology of Nitric Oxide. part 5 ed. Moncada, S., Stamler, J., Gross, S. & Higgs, E.A. p. 104. London: Portland Press.
4. CAVALLINI, L., COASSIN, M., BOREAN, A. & ALEXANDRE, A. (1996). Prostacyclin and sodium nitroprusside inhibit the activity of the platelet inositol 1,4,5-trisphosphate receptor and promote its phosphorylation. J. Biol. Chem., 271, 5545-5551.
5. 2+ channels. Cell Calcium, 19, 269-279.
6. 2+ responses are differentially modulated by nitric oxide via activation of a cyclic GMP-dependent pathway. Mol. Pharmacol., 48, 1068-1077.
7. CORNWELL, T.L., ARNOLD, E., BOERTH, N.J. & LINCOLN, T. (1994). Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol., 267, C1405-C1413.
8. DE MEY, J.G.R., DIJKSTRA, E.H. & VRIJDAG, M.J.J.F. (1991). Endothelium reduces DNA synthesis in isolated arteries. Am. J. Physiol., 260, H1128-H1134.
9. DENIZOT, F. & LANG, R.J. (1986). Rapid colorimetric assay for cell growth and survival. Immunol. Methods, 89, 271-277.
10. 1 phase of nontransformed mammalian cells are absent in transformed cells. Proc. Natl. Acad. Sci. U.S.A., 89, 8626-8630.
11. GARG, U.C., DEVI, L., TURNDORF, H., GOLDFRANK, L.R. & BANSINATH, M. (1992). Effect of nitric oxide on mitogenesis and proliferation of cerebellar glial cells. Brain Res., 592, 208-212.
12. GARG, U.C. & HASSID, A. (1989). Inhibition of rat mesangial cell mitogenesis by nitric oxide-generating vasodilators. Am. J. Physiol., 257, F60-F66.
13. GARG, U.C. & HASSID, A. (1990). Nitric oxide-generating vasodilators inhibit mitogenesis and proliferation of BALB/C 3T3 fibroblasts by a cyclic GMP-independent mechanism. Biochem. Biophys. Res. Commun., 171, 474-479.
14. GARG, U.C. & HASSID, A. (1993). Mechanisms of nitrosothiol-induced antimitogenesis in aortic smooth muscle cells. Eur. J. Pharmacol., 237, 243-249.
15. GARTHWAITE, J., SOUTHAM, E., BOULTON, C.L., NIELSN, E.B., SCHMIDT, K. & MAYER, B. (1995). Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one. Mol. Pharmacol., 48, 184-188.
16. GILBERT, D.M., NEILON, A., MIYAZAWA, H., DEPAMPHELIS, M.L. & BURHANS, W.C. (1995). Mimosine arrests DNA synthesis at replication forks by inhibiting deoxynucleotide metabolism. J. Biol. Chem., 270, 9597-9606.
17. GOUREAU, O., LEPOIVRE, M., BECQUET, F. & CURTOIS, Y. (1993). Differential regulation of inducible nitric oxide synthase by fibroblast growth factor and transforming growth factor-β in bovine retinal pigmented epithelial cells: inverse correlation with cellular proliferation. Proc. Natl. Acad. Sci. U.S.A., 90, 4276-4280.
18. GROSS, S.S. & WOLIN, M.S. (1995). Nitric oxide: pathophysiological mechanisms. Annu. Rev. Physiol., 57, 737-769.
19. GUDI, T., HUVAR, I., MEINECKE, M., LOHMANN, S.M., BOSS, G.R. & PILZ, R.B. (1996). Regulation of gene expression by cGMP-dependent protein kinase. J. Biol. Chem., 271, 4597-4600.
20. 2+ release in guinea-pig hepatocytes. Biochem. J., 318, 849-855.
21. HASSID, A., ARABSHAHI, H., BOURCIER, T., DHAUNSI, G.S. & MATTHEWS, C. (1994). Nitric oxide selectivity amplifies FGF-2-induced mitogenesis in primary rat aortic smooth muscle cells. Am. J. Physiol., 267, H1040-H1048.
22. HENGST, L., DULIC, V., SLINGERLAND, J.M., LEES, E. & REED, S.I. (1994). A cell cycle-regulated inhibitor of cyclin-dependent kinases. Proc. Natl. Acad. Sci. U.S.A., 91, 5291-5295.
23. HOGG, N., DARLEY-USMAR, V.M., WILSON, M.T. & MONCADA, S. (1992). Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide. Biochem. J., 281, 419-424.
24. JENKINS, D.C., CHARLES, I.G., THOMSEN, L.L., MOSS, D.W., HOLMES, L.S., BAYLIS, S.A., RHODES, P., WESTMORE, K., EMSON, P.C. & MONCADA, S. (1995). Roles of nitric oxide in tumor growth. Proc. Natl. Acad. Sci. U.S.A., 92, 4392-4396.
25. JORDAN, M.A., THROWER, D. & WILSON, L. (1992). Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles: implications for the role of microtubule dynamics in mitosis. J. Cell Sci., 102, 401-416.
26. KOLPAKOV, V., GORDON, D. & KULIK, T.J. (1995). Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells. Circ. Res., 76, 505-309.
27. KONTUREK, S.J., BRZOZOWSKI, T., MAJKA, J., PYTKO-POLONCZYK, J. & STACHURA, J. (1993). Inhibition of nitric oxide synthase delays healing of chronic gastric ulcers. Eur. J. Pharmacol., 239, 215-217.
28. LALANDE, M. (1990). A reversible arrest point in the last G1 phase of the mammalian cell cycle. Exp. Cell Res., 186, 332-339.
29. LIN, H., FALCHETTO, R., MOSCA, P.J., SHABANOWITZ, J., HUNT, D.F. & HAMLIN, J. (1996). Mimosine targets serine methyltransferase. J. Biol. Chem., 271, 2548-2556.
30. MAGNI, M., MELDOLESI, J. & PANDIELA, A. (1991). Ionic events induced by epidermal growth factor. J. Biol. Chem., 266, 6329-6335.
31. MIYAZAKI, M., WAHID, S., BAI, L. & NAMBA, M. (1992). Effects of intracellular cyclic AMP and cyclic GMP levels on DNA synthesis of young-adult rat hepatocytes in primary culture. Exp. Cell Res., 200, 404-409.
32. MOORE, E.C. & HURLBERT, R.B. (1985). The inhibition of ribonucleoside diphosphate reductase by hydroxyurea, guanazole and pyrazoloimidazole (IMPY). Pharmacol. Ther., 27, 167-196.
33. MORRIS, B.J. (1995). Stimulation of immediate early gene expression in striatal neurons by nitric oxide. J. Biol. Chem., 270, 24740-24744.
34. MUÑOZ-FERNÀNDEZ, M.A. & FRESNO, M. (1993). Involvement of nitric oxide on the cytokine induced growth of glial cells. Biochem. Biophys. Res. Commun., 194, 319-325.
35. 2+ entry in human platelets. Biochem. J., 310, 263-269.
36. NERLOV, C., DE CESARE, D., PERGOLA, F., CARACCIOLO, A., BLASI, F., JOHNSEN, M. & VERDE, P. (1992). A regulatory element that mediates co-operation between a PEA3-AP-1 element and an AP-1 site is required for phorbol ester induction of urokinase enhancer activity in HepG2 hepatoma cells. EMBO J., 11, 4573-4582.
37. NEWBY, A.C., SOUTHGATE, K.M. & ASSENDER, J.W. (1992). Inhibition of vascular smooth muscle cell proliferation by endothelium-dependent vasodilators. Herz, 17, 291-299.
38. PERANOVICH, T.M., DA SILVA, A.M., FRIES, D.M., STERN, A. & MONTEIRO, H.P. (1995). Nitric oxide stimulates tyrosine phosphorylation in murine fibroblasts in the absence and presence of epidermal growth factor. Biochem. J., 305, 613-619.
39. PEUNOVA, N. & ENIKOLOPOV, G. (1993). Amplification of calcium-induced gene transcription by nitric oxide in neuronal cells. Nature, 364, 450-453.
40. PEUNOVA, N. & ENIKOLOPOV, G. (1995). Nitric oxide triggers a switch to growth arrest during differentiation of neuronal cells. Nature, 375, 68-73.
41. PILZ, R.B., SUHASINI, M., IDRISS, S., MEINKOTH, J.L. & BOSS, G.R. (1995). Nitric oxide and cGMP analogs activate transcription from AP-1-responsive promoters in mammalian cells. FASEB J., 9, 552-558.
42. PUNJABI, C.J., LASKIN, D.L., HECK, D.E. & LASKIN, J.D. (1992). Production of nitric oxide by murine bone marrow cells. Inverse correlation with cellular proliferation. J. Immunol., 149, 2179-2184.
43. RØRTH, P., NERLOV, C., BLASI, F. & JOHNSEN, M. (1990). Transcription factor PEA3 participates in the induction of urokinase plasminogen activator transcription in murine keratinocytes stimulated with epidermal growth factor or phorbolester. Nucleic Acid Res., 18, 5009-5017.
44. ROSKAMS, A.J., BREDT, D.S., DAWSON, T.M. & RONNETT, G.V. (1994). Nitric oxide mediates the formation of synaptic connections in developing and regenerating olfactory receptor neurones. Neuron, 13, 289-299.
45. VINDELOV, L. & CHRISTENSEN, J.B.J. (1990). An integrated set of methods for routine flow cytometric DNA analysis. Methods Cell Biol., 33, 127-137.
46. WU, H.H., WILLIAMS, C.V. & MCLOON, S.C. (1994). Involvement of nitric oxide in the elimination of a transient retinotectal projection in development. Science, 265, 1593-1596.
47. 2+ influx. J. Biol. Chem., 269, 12645-12653.
48. YANG, W., ANDO, J., KORENAGA, R., TOYO-OKA, T. & KAMIYA, A. (1994). Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial cells. Biochem. Biophys. Res. Commun., 203, 1160-1167.
49. YOSHIDA, M., YAMAMOTO, M. & NIKAIDO, T. (1992). Quercetin arrests human leukemic T-cells in late G1 phase of the cell cycle. Cancer Res., 52, 6676-6681.
50. YU, S.-M., HUNG, L.-M. & LIN, C.-C. (1997). cGMP-elevating agents suppress proliferation of vascular smooth muscle cells by inhibiting the activation of epidermal growth factor signaling pathway. Circulation, 95, 1269-1277.
51. ZICHE, M., MORBIDELLI, L., MASINI, E., AMERINI, S., GRANGER, H.J., MAGGI, C.A., GEPPETTI, P. & LEDDA, F. (1994). Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vivo promoted by substance P. J. Clin. Invest., 94, 2036-2044.