Effects of divalproex sodium on 5-HT(1A) receptor function in healthy human males: Hypothermic, hormonal, and behavioral responses to ipsapirone

Neuropsychopharmacology

Volumn 17, Issue 6, 1997, Pages 382-390

  Shiah, I Shin ^a   Yatham, Lakshmi N ^a   Lam, Raymond W ^a   Zis, Athanasios P ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

5 HT(1A) receptors; ACTH; Cortisol; Divalproex sodium; Hypothermia; Ipsapirone; Serotonin

Indexed keywords

AUTORECEPTOR; CORTICOTROPIN; HYDROCORTISONE; IPSAPIRONE; SEROTONIN 1A RECEPTOR; VALPROATE SEMISODIUM;

ANXIETY; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DIARRHEA; DROWSINESS; HEADACHE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYPOTHERMIA; MALE; NAUSEA; NEUROTRANSMISSION; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROVOCATION TEST;

ADRENOCORTICOTROPIC HORMONE; ADULT; ANTIMANIC AGENTS; BEHAVIOR; BODY TEMPERATURE; HORMONES; HUMANS; HYDROCORTISONE; MALE; PYRIMIDINES; RECEPTORS, SEROTONIN; SEROTONIN AGONISTS; VALPROIC ACID;

EID: 0030693326     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(97)00087-0     Document Type: Article

References (49)

1. Akiyoshi J, Tsuchiyama K, Yamada K, Oba A, Yamada K, Kojima K, Sasaki I, Nagayama H (1995): Effects of 8-OH-DPAT on corticosterone after acute and chronic administration of antidepressants. Prog Neuro-psychopharmcol Biol Psychiat 19:93-103
2. Anderson IM, Cowen PJ (1992): Effect of pindolol on endocrine and temperature responses to buspirone in healthy volunteers. Psychopharmacology 106:428-432
3. Anderson IM, Cowen PJ, Grahame-Smith DG (1990): The effects of gepirone on neuroendocrine function and temperature in humans. Psychopharmacology 100:498-503
4. Aulakh CS, Wozniak KM, Hill JL, Murphy DL (1988): Differential effects of long-term antidepressant treatments on 8-OH-DPAT-induced increases in plasma prolactin and corticosterone in rats. Eur J Pharmacol 156:395-400
5. 1A) and 5-HT2 receptor agonist-induced oxytocin, prolactin, and corticosterone responses. Endocrinology 134:1127-1131
6. Biggs CS, Pearce BR, Fowler LJ, Whitton PS (1992): Regional effects of sodium valproate on extracellular concentrations of 5-hydroxytryptamine, dopamine and their metabolites in the rat brain: An in vivo microdialysis study. J Neurochem 59:1072-1078
7. Bill A, Knight M, Forster EA, Fletcher A (1991): Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia. Br J Pharmacol 103:1857-1864
8. 1A receptor activation and hypothermia: Evidence for a postsynaptic mechanism in humans. Neuropsychopharmacology 10 (3S, part 2):92S
9. Fahn S (1978): Post-anoxic myoclonus improvement with valproic acid. N Engl J Med 319:313-314
10. 2 receptor-mediated adrenocorticotropin release in the rat: effect of repeated antidepressant treatments. Eur J Pharmacol 221:27-33
11. 1A receptor subtype increases rat ACTH concentration. Eur J Pharmacol 147:431-439
12. 1A function. Neuropharmacology 24:1187-1194
13. Goodwin GM, DeSouza RJ, Green AR (1985b): Presynaptic serotonin receptor-mediated response in mice attenuated by antidepressant drugs and electroconvulsive shock. Nature 317:531-533
14. 2-adrenoreceptor mediated function in mice. Psychopharmacology 90:482-487
15. Goodwin GM, DeSouza RJ, Green AR, Heal DJ (1987): The pharmacology of the behavioral and hypothermic responses of rats to 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Psychopharmacology 91: 506-511
16. Hillegaart V (1991): Effects of local application of 5-HT and 8-OH-DPAT into the dorsal and median raphe nuclei on core temperature in the rat. Psychopharmacology 103: 291-296
17. Hjorth S (1985): Hypothermia in the rat induced by the potent serotonergic agent 8-OH-DPAT. J Neural Transm 55:169-188
18. 1A agonists LY-165163 and 8-OH-DPAT is not prevented by 5-HT depletion. Eur J Pharmacol 143:221-228
19. Kempf EG, Mack CS, Mandel P (1982): Effect of valproic acid on brain serotonin metabolism in isolated and grouped rats. Pharmacol Biochem Behav 17:49-52
20. Khaitan L, Calabrese JR, Stockmeier CA (1994): Effects of chronic treatment with valproate on serotonin-1A receptor binding and function. Psychopharmacology 113:539-542
21. Koenig JI, Meltzer HY, Gudelsky GA (1987): Stimulation of corticosterone and β-endophin secretion in the rat by selective 5-HT receptor subtype activation. Eur J Pharmacol 143:221-228
22. Lee HS, Meltzer HY (1991): Buspirone does not produce a 5-HT1A-mediated decrease in temperature in man. J Neural Transm 86:71-76
23. Lesch KP, Rupprecht R, Poten B, Muller U, Sohnle K, Fritze J, Schulte HM (1989a): Endocrine responses to 5-hydroxytryptamine-1A receptor activation by ipsapirone in humans. Biol Psychiatry 26:203-205
24. 1A) receptor function in affective disorders. Pharmacopsychiatry 22:205 (Abstract)
25. 1A) receptor activation: effects of 5-HT receptor and β-adrenoceptor antagonists. J Clin Endocrinol Metab 70:670-674
26. 1A receptor activation in humans. Eur J Clin Pharmacol 39:17-19
27. 1A receptor function in depression: Effect of chronic amitriptyline treatment. J Neural Transm 80:157-161
28. 1A receptor responsivity in obsessive-compulsive disorder. Psychopharmacology 105:415-420
29. 1A receptor responsivity in anxiety disorders and depression. Prog Neuro-Psychopharmacol & Biol Psychiat 15:723-733
30. 1A receptor challenge in anxiety disorders and depression. In Stahl SM, Gastpar M, Keppel Hesselink JM, Traber J (eds), Serotonin 1A receptors in depression and anxiety. New York, Raven Press, pp 135-162
31. 1A agonist, 8-OH-DPAT, in male rats. Brain Res 630:148-156
32. 1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats. Biol Psychiatry 36:300-308
33. Maes M, Calabrese JR (1994): Mechanisms of action of valproate in affective disorders. In Joffe RT, Calabrese JR (eds), Anticonvulsants in Mood Disorders. New York, Marcel Dekker, pp 93-110
34. Maes M, Meltzer HYM (1995): The serotonin hypothesis of major depression. In Bloom F, Kupfer D (eds), Psychopharmacology, The Fourth Generation of Progress. New York, Raven, pp 933-944
35. Maj J, Moryl K (1992): Effects of setraline and citalopram given repeatedly on the responsiveness of 5-HT receptor subpopulations. J Neural Transm 88:143-156
36. 1A autoreceptor response and its evaluation as a model to selectively identify antidepressants. Br J Pharmacol 107:15-21
37. Mcelory SL, Keck PE, Pope HG, Hudson JI (1992): Valproate in the treatment of bipolar disorder: Literature review and clinical guidelines. J Clin Psychopharmacol 12:42S-52S
38. 1A receptor activation. Br J Pharmacol 106:603-609
39. Peroutka SJ (1988): 5-Hydroxytryptamine receptor subtypes: Molecular, biochemical and physiological characterization. Trends Neurosci 11:496-500
40. 1A receptor activation by flesinoxan in humans: Body temperature and neuroendocrine responses. Neuropsychopharmacology 13:93-104
41. Shiah IS, Yatham LN, Zis AP, Lam RW (1997): Lamotrigine treatment and serotonin receptor function. New Research Abstract, 150th Annual Meeting, American Psychiatry Association, San Diego, p 94
42. Shukla GS (1985): Combined lithium and valproate treatment and subsequent withdrawal: Serotonergic mechanism of their interaction in discrete brain regions. Prog Neuropsychopharmacol Biol Psychiatry 9:153-156
43. Spitzer RL, Williams JBW, Gibbon M, First MB (1992): Structured Clinical Interview for DSM-III-R, Nonpatient edition. Washington, DC, American Psychiatric Association
44. Urban JH, Van de Kar LD, Lorens SA, Bethea CL (1986): Effects of the anxiolytic drug buspirone on prolactin and corticosterone secretion in stressed and unstressed rats. Pharmacol Biochem Behav 25:457-462
45. 1A receptor sensitivity: A neuroendocrine study in healthy volunteers. Psychopharmacology 105:568-572
46. Whitton PS, Oreskovic D, Jernej B, Bulat M (1985): Effect of valproic acid on 5-hydroxytryptamine turnover in mouse brain. J Pharm Pharmac 37:194-200
47. Whitton PS, Fowler LJ (1991): The effect of valproic acid on 5-hydroxytryptamine and 5-hydroxyindoleacetic acid concentration in hippocampal dialysates in vivo. Eur J Pharmacol 200:167-169
48. Wing YK, Clifford FM, Sheehan BD, Campling GM, Hockney RA, Cowen PJ (1996): Paroxetine treatment and the prolactin response to sumatriptan. Psychopharmacol-ogy 124:377-379
49. Yatham LN, Steiner M (1993): Neuroendocrine probes of serotonergic function: A critical review. Life Sci 53:447-463