Inhibition of muscarinic receptor-operated Ca2+ sensitization by short-term desensitization of α-toxin-permeabilized smooth muscle cells from guinea pig stomach

General Pharmacology

Volumn 29, Issue 5, 1997, Pages 753-761

  Mita, Mitsuo ^a   Satoh Akimoto, Koji ^a   Oishi, Kazuhiko ^a   Hashimoto, Takao ^a   Uchida, Masaatsu K ^a  

^a MEIJI PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Toxin; Acetylcholine; Ca2+ sensitivity; Desensitization; Fundus of stomach; GTP binding protein; Muscarinic receptor; Permeabilization; Smooth muscle cells

Indexed keywords

ACETYLCHOLINE; ALPHA TOXIN; CALCIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC RECEPTOR;

ARTICLE; CONTROLLED STUDY; DESENSITIZATION; GUINEA PIG; HUMAN TISSUE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; STAPHYLOCOCCUS AUREUS; STOMACH FUNDUS;

ACETYLCHOLINE; ANIMALS; CALCIUM; CELL MEMBRANE PERMEABILITY; GASTRIC FUNDUS; GUANOSINE TRIPHOSPHATE; GUINEA PIGS; MUSCARINIC ANTAGONISTS; MUSCLE CONTRACTION; MUSCLE, SMOOTH; PHOSPHOLIPASE C; RECEPTORS, MUSCARINIC; STOMACH;

EID: 0030692736     PISSN: 03063623     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0306-3623(97)00033-5     Document Type: Article

References (35)

1. Bradley A. B. and Morgan K. G. (1987) Alterations in cytoplasmic calcium sensitivity during porcine coronary artery contractions as detected by aequorin. J. Physiol. 385, 437-448.
2. Dohlman H. G., Thoner J., Caron M. G. and Lefkowitz R. J. (1991) Model systems for the study of seven-transmembrane-segment receptors. Annu. Rev. Biochem. 60, 653-688.
3. Haga K. and Haga T. (1990) Dual regulation by G proteins of agonist-dependent phosphorylation of muscarinic acetylcholinc receptors. FEBS Lett. 268, 43-47.
4. Haga T. and Haga K. (1989) Agonist-dependent phosphorylation of cerebral and atrial muscarinic receptors: blockade of phosphorylation by GTP-binding regulatory proteins and its reversal by guanine nucleotides. Biomed. Res. 10, 293-299.
5. Haga K., Haga T. and Ichiyama A. (1990) Phosphorylation by protein kinase C of the muscarinic acetylcholine receptor. J. Neurochem. 54, 1639-1644.
6. Haga T., Haga K. and Kameyama K. (1994) G-protein-coupled receptor kinases. J. Neurochem. 63, 400-412.
7. Haga T., Haga K., Kameyama K. and Nakata H. (1993) Phosphorylation of muscarinic receptors: regulation by G proteins. Life Sci. 52, 421-428.
8. Harafuji H. and Ogawa Y. (1980) Re-examination of the apparent binding constant of ethylene glycol bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid with calcium around neutral pH. J. Biochem. 87, 1305-1312.
9. Hirata K., Kikuchi A., Sasaki T., Kuroda S., Kaibuchi K., Matsuura Y., Seki H., Saida K. and Takai Y. (1992) Involvement of rho p21 in the GTP-enhanced calcium ion sensitivity of smooth muscle contraction. J. Biol. Chem. 267, 8719-8722.
10. Inoue R. and Isenberg G. (1990) Intracellular calcium ions modulate acetylcholine-induced inward current in guinea-pig ileum. J. Physiol. 424, 73-92.
11. 2+ localization and sensitivity in vascular smooth muscle. Trends Pharmac. Sci. 10, 320-325.
12. 2+ sensitization in α-toxin-permeabilized vascular smooth muscle. Eur. J. Pharmac. 214, 39-44.
13. 2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 266, 1708-1715.
14. 2+. J. Biol. Chem. 264, 5339-5342.
15. Kwatra M. M. and Hosey M. M. (1986) Phosphorylation of the cardiac muscarinic receptor in intact chick heart and its regulation by a muscarinic agonist. J. Biol. Chem. 261, 12429-12432.
16. Kwatra M. M., Leung E., Maan A. C., Mcmahon K. K., Ptasienski J., Green R. D. and Hosey M. M. (1987) Correlation of agonist-induced phosphorylation of chick heart muscarinic receptors with receptor desensitization. J. Biol. Chem. 262, 16314-16321.
17. Lefkowitz R. J., Hausdorff W. P. and Caron M. G. (1990) Role of phosphorylation in desensitization of the beta-adrenoceptor. Trends Pharmac. Sci. 11, 190-194.
18. 2+ sensitivity in α-toxin-permeabilized single smooth muscle cells from guinea-pig taenia caecum. Br. J. Pharmac. 115, 522-526.
19. 2+ deprivation on short-term desensitization of isolated smooth muscle cells showing an all-or-none response to acetylcholine. Gen. Pharmac. 19, 441-445.
20. 2+ sensitization. Comp. Biochem. Physiol. 107C, 41-49.
21. Mita M., Ono T., Hashimoto T. and Uchida M. K. (1993) All-or-none shortening of isolated single smooth muscle cells from different organs to acetylcholine. Gen. Pharmac. 24, 1085-1090.
22. Mita M. and Uchida M. K. (1987) Desensitization of isolated smooth muscle cells from guinea pig taenia caecum to acetylcholine. Can. J. Physiol. Pharmac. 65, 293-297.
23. 2+ influx in the all-or-none response to acetylcholine of isolated smooth muscle cells. Eur. J. Pharmac. 151, 9-17.
24. Mita M. and Uchida M. K. (1991) The change in the threshold for short-term desensitization in isolated smooth muscle cells showing an all-or-none response to acetylcholine. Br. J. Pharmac. 104, 603-508.
25. Nakata H., Kameyama K., Haga K. and Haga T. (1994) Location of agonist-dependent phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype). Eur. J. Biochem. 220, 29-36.
26. 2+ sensitivity in α-toxin permeabilized arterial smooth muscle. Biochem. Biophys. Res. Commun. 157, 677-683.
27. 2+ in α-toxin-permeabilized smooth muscle cells from the guinea-pig stomach. Br. J. Pharmac. 107, 908-909.
28. Ono T., Mita M., Suga O., Hashimoto T., Oishi K. and Uchida M. K. (1992) Receptor-coupled shortening of α-toxin-permeabilized single smooth muscle cells from the guinea-pig stomach. Br. J. Pharmac. 106, 539-543.
29. Palczewski K. and Benovic J. L. (1991) G-protein-coupled receptor kinases. Trends Biochem. Sci. 16, 387-391.
30. 2+-responsiveness of smooth muscle contraction. FEBS Lett. 324, 211-215.
31. Sibley D. R. and Lefkowitz R. J. (1985) Molecular mechanisms of receptor desensitization using the β-adrenergic receptor-coupled adenylate system as a model. Nature (Land.) 317, 124-129.
32. Tobin A. B. and Nahorski S. R. (1993) Rapid agonist-mediated phosphorylation of m3-muscarinic receptors revealed by immunoprecipitation. J. Biol. Chem. 268, 9817-9823.
33. Triggle D. J. (1980) Desensitization. Trends Pharmacol. Sci. 2, 395-399.
34. Uchiyama H., Ohara K., Haga K., Haga T. and Ichiyama A. (1990) Location in muscarinic acetylcholine receptors of sites for propylbenzilylcholine mustard binding and for phosphorylation with protein kinase. C. J. Neurochem. 54, 1870-1881.
35. Wojcikiewicz R. J. H., Tobin A. B. and Nahorski S. R. (1993) Desensitization of cell signalling mediated by phosphoinositidase C. Trends Pharmac. Sci. 14, 279-285.