Characterisation of genotoxic properties of 2',2'-difluorodeoxycytidine

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 393, Issue 1-2, 1997, Pages 165-173

  Auer, Herbert ^a   Oehler, Rudolf ^b   Lindner, Regina ^b   Kowalski, Heinrich ^b   Sliutz, Gerhard ^b   Orel, Lukas ^a   Kucera, Elisabeth ^b   Simon, Manuel M ^a   Glössl, Josef ^a  

^a UNIVERSITY OF NATURAL RESOURCES AND LIFE SCIENCES   (Austria)

^b UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Cell cycle; Chromosome aberration; DNA single strand break; Gemcitabine; Genotoxicity; Micronucleus; Sister chromatid exchange

Indexed keywords

GEMCITABINE;

ARTICLE; CELL STRAIN V 79; CHROMOSOME ABERRATION; CONTROLLED STUDY; GENOTOXICITY; HUMAN; HUMAN CELL; MALE; MICRONUCLEUS TEST; PRIORITY JOURNAL; SISTER CHROMATID EXCHANGE;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELL LINE, TRANSFORMED; CELLS, CULTURED; CHROMOSOME ABERRATIONS; DEOXYCYTIDINE; DNA DAMAGE; HUMANS; MICRONUCLEUS TESTS; MUTAGENS; SISTER CHROMATID EXCHANGE;

EID: 0030692119     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1383-5718(97)00102-2     Document Type: Article

References (25)

1. Magnani C., Terracini B., Cordero Di Montezemolo L., Gallone G., Luzzatto L., Mosso M.L., Pastore G., Rosso P. Incidence of second primary malignancies after a malignant tumor in childhood: a population-based survey in Piedmont (Italy). Int. J. Cancer. 67:1996;6-10.
2. Scaradavou A., Heller G., Sklar C.A., Ren L., Ghavimi F. Second malignant neoplasms in long-term survivors of childhood rhabdomyosarcoma. Cancer. 76:1995;1860-1867.
3. Smith M.A., McCaffrey R.P., Karp J.E. The secondary leukemias: challenges and research directions. J. Natl. Cancer Inst. 88:1996;407-418.
4. Brumen V., Horvath D. Work environment influence on cytostatics-induced genotoxicity in oncologic nurses. Am. J. Ind. Med. 30:1996;67-71.
5. Fuchs J., Hengstler J.G., Jung D., Hiltl G., Konietzko J., Oesch F. DNA damage in nurses handling antineoplastic agents. Mutation Res. 342:1995;17-23.
6. Huang P., Plunkett W. Induction of apoptosis by gemcitabine. Semin. Oncol. 22:1995;19-25.
7. Plunkett W., Huang P., Xu Y.Z., Heinemann V., Grunewald R., Gandhi V. Gemcitabine: metabolism, mechanisms of action, and self-potentiation. Semin. Oncol. 22:1995;3-10.
8. Huang P., Chubb S., Hertel L.W., Grindey G.B., Plunkett W. Action of 2′,2′-difluorodeoxycytidine on DNA synthesis. Cancer Res. 51:1991;6110-6117.
9. Schy W.E., Hertel L.W., Kroin J.S., Bloom L.B., Goodman M.F., Richardson F.C. Effect of a template-located 2′,2′-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3′→5′exonuclease-) fragment. Cancer Res. 53:1993;4582-4587.
10. Simon M.M., Reikerstorfer A., Schwarz A., Krone C., Luger T.A., Jaattela M., Schwarz T. Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. Evidence for increased cell viability and suppression of cytokine release. J. Clin. Invest. 95:1995;926-933.
11. Perry P., Wolff S. New giemsa method for differential staining of sister chromatids. Nature. 251:1974;156-158.
12. Fenech M. The cytokinesis-block micronucleus assay in nucleated cells. Prog. Clin. Biol. Res. 340B:1990;195-206.
13. Karlseder J., Wissing D., Holzer G., Orel L., Sliutz G., Auer H., Jaattela M., Simon M.M. HSP70 overexpression mediates the escape of a doxorubicin-induced G2 cell cycle arrest. Biochem. Biophys. Res. Commun. 220:1996;153-159.
14. Kasten U., Beyersmann D., Dahm-Daphi J., Hartwig A. Sensitive nonradioactive detection of UV-induced cyclobutane pyrimidine dimers in intact mammalian cells. Mutation Res. 336:1995;143-152.
15. Whitacre C.M., Hashimoto H., Tsai M.L., Chatterjee S., Berger S.J., Berger N.A. Involvement of NAD-poly(ADP-ribose) metabolism in p53 regulation and its consequences. Cancer Res. 55:1995;3697-3701.
16. Stasi R., Venditti A., Del-Poeta G., Aronica G., Abruzzese E., Pisani F., Cecconi M., Masi M., Amadori S. High-dose chemotherapy in acute myeloid leukemia: rationale and results. Leuk. Res. 20:1996;535-549.
17. Mourelatos D., Dozi-Vassiliades J., Tsigalidou-Balla V., Granitsas A. Enhancement by methylxanthines of sister-chromatid exchange frequency induced by cytostatics in normal and leukemic human lymphocytes. Mutation Res. 121:1983;147-152.
18. van Haperen V.W., Veerman G., Vermorken J.B., Pinedo H.M., Peters G. Regulation of phosphorylation of deoxycytidine and 2′,2′-difluorodeoxycytidine (gemcitabine); effects of cytidine 5′-triphosphate and uridine 5′-triphosphate in relation to chemosensitivity for 2′,2′-difluorodeoxycytidine. Biochem. Pharmacol. 51:1996;911-918.
19. Ruiz van Haperen V.W., Veerman G., Eriksson S., Stegmann A.P., Peters G.J. Induction of resistance to 2′,2′-difluorodeoxycytidine in the human ovarian cancer cell line A2780. Semin. Oncol. 22:1995;35-41.
20. Sliutz G., Karlseder J., Tempfer C., Orel L., Holzer G., Simon M.M. Drug resistance against gemcitabine and topotecan mediated by constitutive hsp70 overexpression in vitro: implication of quercetin as sensitiser in chemotherapy. Br. J. Cancer. 74:1996;172-177.
21. Das S.K. Activation of a well-behaved cell cycle in araC-treated V79 cells by caffeine. Mutation Res. 207:1988;171-177.
22. Popescu N.C., Amsbaugh S.C., DiPaolo J.A. Human and rodent transformed cells are more sensitive to in vitro induction of SCE by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) than normal cells. Hum. Genet. 63:1983;53-57.
23. Cox L.S., Lane D.P. Tumour suppressors, kinases and clamps: how p53 regulates the cell cycle in response to DNA damage. Bioessays. 17:1995;501-508.
24. Moro F., Ottaggio L., Bonatti S., Simili M., Miele M., Bozzo S., Abbondandolo A. p53 expression in normal versus transformed mammalian cells. Carcinogenesis. 16:1995;2435-2440.
25. Waldman T., Lengauer C., Kinzler K.W., Vogelstein B. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature. 381:1996;713-716.