-
1
-
-
0030062296
-
Human gene therapy - An immature genie, but certainly out of the bottle
-
Friedmann T. Human gene therapy - an immature genie, but certainly out of the bottle. Nat Med. 2:1996;144-147.
-
(1996)
Nat Med
, vol.2
, pp. 144-147
-
-
Friedmann, T.1
-
2
-
-
0028875936
-
Transfer of genes to humans: Early lessons and obstacles to success
-
Crystal R. Transfer of genes to humans: early lessons and obstacles to success. Science. 270:1995;404-410.
-
(1995)
Science
, vol.270
, pp. 404-410
-
-
Crystal, R.1
-
3
-
-
0028328261
-
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
-
Yang Y, Nunes F, Berensci K, Furth E, Gonczol E, Wilson J. Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc Natl Acad Sci USA. 91:1994;4407-4411.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 4407-4411
-
-
Yang, Y.1
Nunes, F.2
Berensci, K.3
Furth, E.4
Gonczol, E.5
Wilson, J.6
-
4
-
-
0028807696
-
FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus mediated gene transfer
-
Vilquin J, Guerette B, Kinoshita I, Roy R, Goulet M, Gravel C, Ray R, Tremblay J. FK506 immunosuppression to control the immune reactions triggered by first-generation adenovirus mediated gene transfer. Hum Gene Ther. 6:1995;1391-1401.
-
(1995)
Hum Gene Ther
, vol.6
, pp. 1391-1401
-
-
Vilquin, J.1
Guerette, B.2
Kinoshita, I.3
Roy, R.4
Goulet, M.5
Gravel, C.6
Ray, R.7
Tremblay, J.8
-
5
-
-
0029095375
-
Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: Effects on vector induced inflammation
-
McCoy R, Davidson B, Roessler B, Huffnagle G, Simon R. Expression of human interleukin-1 receptor antagonist in mouse lungs using a recombinant adenovirus: effects on vector induced inflammation. Gene Ther. 2:1995;437-442.
-
(1995)
Gene Ther
, vol.2
, pp. 437-442
-
-
McCoy, R.1
Davidson, B.2
Roessler, B.3
Huffnagle, G.4
Simon, R.5
-
6
-
-
0029780119
-
CD40 ligand-dependent T cell activation requirement of B7-CD28 signalling through CD40
-
Yang Y, Wilson J. CD40 ligand-dependent T cell activation requirement of B7-CD28 signalling through CD40. Science. 274:1996;1862-1864.
-
(1996)
Science
, vol.274
, pp. 1862-1864
-
-
Yang, Y.1
Wilson, J.2
-
7
-
-
0028978493
-
Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
-
Yang Y, Trinchieri G, Wilson J. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung. Nat Med. 1:1995;890-893.
-
(1995)
Nat Med
, vol.1
, pp. 890-893
-
-
Yang, Y.1
Trinchieri, G.2
Wilson, J.3
-
8
-
-
0029968303
-
Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2
-
Kaplan J, St George J, Pennington S, Keyes L, Johnson R, Wadsworth S, Smith A. Humoral and cellular immune responses of nonhuman primates to long-term repeated lung exposure to Ad2/CFTR-2. Gene Ther. 3:1996;117-127.
-
(1996)
Gene Ther
, vol.3
, pp. 117-127
-
-
Kaplan, J.1
St George, J.2
Pennington, S.3
Keyes, L.4
Johnson, R.5
Wadsworth, S.6
Smith, A.7
-
9
-
-
0030460250
-
Retroviral targeted delivery
-
Schnierle B, Groner B. Retroviral targeted delivery. Gene Ther. 3:1996;1069-1073.
-
(1996)
Gene Ther
, vol.3
, pp. 1069-1073
-
-
Schnierle, B.1
Groner, B.2
-
10
-
-
0031058024
-
Recombinant adeno-associated virus for muscle directed gene therapy
-
Fisher K, Jooss K, Alston J, Yang Y, Haecker S, High K, Pathak R, Raper S, Wilson J. Recombinant adeno-associated virus for muscle directed gene therapy. Nat Med. 3:1997;306-312.
-
(1997)
Nat Med
, vol.3
, pp. 306-312
-
-
Fisher, K.1
Jooss, K.2
Alston, J.3
Yang, Y.4
Haecker, S.5
High, K.6
Pathak, R.7
Raper, S.8
Wilson, J.9
-
11
-
-
0031048964
-
Engineering herpes simplex virus vectors for gene transfer to neurons
-
Fink D, Glorioso J. Engineering herpes simplex virus vectors for gene transfer to neurons. Nat Med. 3:1997;357-359.
-
(1997)
Nat Med
, vol.3
, pp. 357-359
-
-
Fink, D.1
Glorioso, J.2
-
12
-
-
0028997824
-
Immunomodulation of pancreatic islet allografts in mice with CTLA4Ig secreting muscle cells
-
Chahine A, Yu M, McKernan M, Stoeckert C, Lau H. Immunomodulation of pancreatic islet allografts in mice with CTLA4Ig secreting muscle cells. Transplantation. 59:1995;1313-1318.
-
(1995)
Transplantation
, vol.59
, pp. 1313-1318
-
-
Chahine, A.1
Yu, M.2
McKernan, M.3
Stoeckert, C.4
Lau, H.5
-
13
-
-
0030017476
-
Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice
-
of outstanding interest. An interesting study in which Fas ligand expressed in myoblasts syngeneic with the recipient were used to protect allogeneic islets of Langerhans from rejection in a mouse model of diabetes. Survival of the transplanted islets reversed the diabetic state.
-
Lau H, Yu M, Fontana A, Stoeckert C. Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice. of outstanding interest Science. 273:1996;109-112 An interesting study in which Fas ligand expressed in myoblasts syngeneic with the recipient were used to protect allogeneic islets of Langerhans from rejection in a mouse model of diabetes. Survival of the transplanted islets reversed the diabetic state.
-
(1996)
Science
, vol.273
, pp. 109-112
-
-
Lau, H.1
Yu, M.2
Fontana, A.3
Stoeckert, C.4
-
14
-
-
0028963532
-
Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model
-
Qin L, Chavin K, Ding Y, Favaro J, Woodward J, Lin J, Tahara H, Robbins P, Shaked A, Ho D, et al. Multiple vectors effectively achieve gene transfer in a murine cardiac transplantation model. Transplantation. 59:1995;809-816.
-
(1995)
Transplantation
, vol.59
, pp. 809-816
-
-
Qin, L.1
Chavin, K.2
Ding, Y.3
Favaro, J.4
Woodward, J.5
Lin, J.6
Tahara, H.7
Robbins, P.8
Shaked, A.9
Ho, D.10
-
15
-
-
13344249764
-
Retrovirus mediated gene transfer of viral IL-10 gene prolongs murine caridac allograft survival
-
of outstanding interest. Delivery of viral, but not mouse, IL-10 directly to neonatal heart tissue using a replication retrovirus delivery system resulted in the prolongation of graft survival as compared with the controls (mean survival time 39.4 days compared with 12.1 days respectively).
-
Qin L, Chavin K, Ding Y, Takahar H, Favaro J, Woodard J, Susuki T, Robbins P, Lotze M, Bromberg J. Retrovirus mediated gene transfer of viral IL-10 gene prolongs murine caridac allograft survival. of outstanding interest J Immunol. 156:1996;2316-2323 Delivery of viral, but not mouse, IL-10 directly to neonatal heart tissue using a replication retrovirus delivery system resulted in the prolongation of graft survival as compared with the controls (mean survival time 39.4 days compared with 12.1 days respectively).
-
(1996)
J Immunol
, vol.156
, pp. 2316-2323
-
-
Qin, L.1
Chavin, K.2
Ding, Y.3
Takahar, H.4
Favaro, J.5
Woodard, J.6
Susuki, T.7
Robbins, P.8
Lotze, M.9
Bromberg, J.10
-
16
-
-
0030449531
-
Decreased alloreactivity to human islets secreting viral interleukin 10
-
of special interest. An in vitro study demonstrating that the expression of viral IL-10 in isolated human islets of Langerhans, using a replication defective adenovirus delivery system, resulted in the perturbation of proliferative responses in mixed islet lymphocyte reactions. The functional effect of the secreted cytokine was found to be dose dependent. Low level viral IL-10 secretion augmented lymphocyte proliferation whereas high levels inhibited proliferation
-
Benhamou P, Mullen Y, Shaked A, Bahmiller D, Csete M. Decreased alloreactivity to human islets secreting viral interleukin 10. of special interest Transplantation. 62:1996;1306-1312 An in vitro study demonstrating that the expression of viral IL-10 in isolated human islets of Langerhans, using a replication defective adenovirus delivery system, resulted in the perturbation of proliferative responses in mixed islet lymphocyte reactions. The functional effect of the secreted cytokine was found to be dose dependent. Low level viral IL-10 secretion augmented lymphocyte proliferation whereas high levels inhibited proliferation.
-
(1996)
Transplantation
, vol.62
, pp. 1306-1312
-
-
Benhamou, P.1
Mullen, Y.2
Shaked, A.3
Bahmiller, D.4
Csete, M.5
-
17
-
-
0029808332
-
Local production of the p40 subunit of interleukin 12 suppresses T helper-1 mediated immune responses and prevents allogeneic myoblast rejection
-
of special interest. Another approach where a molecule with immunomodulatory potential is expressed in allogeneic tissue before transplantation
-
Kato K, Shimozato O, Hoshi K, Wakimoto H, Hamada H, Yagita H, Okumura K. Local production of the p40 subunit of interleukin 12 suppresses T helper-1 mediated immune responses and prevents allogeneic myoblast rejection. of special interest Proc Natl Acad Sci USA. 93:1996;9085-9089 Another approach where a molecule with immunomodulatory potential is expressed in allogeneic tissue before transplantation.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 9085-9089
-
-
Kato, K.1
Shimozato, O.2
Hoshi, K.3
Wakimoto, H.4
Hamada, H.5
Yagita, H.6
Okumura, K.7
-
18
-
-
0028927620
-
Adenovirus-mediated gene transfer in the transplant setting
-
Drazan K, Wu L, Shen X, Bullington D, Jurim O, Busuttil R, Shaked A. Adenovirus-mediated gene transfer in the transplant setting. Transplantation. 59:1995;670-673.
-
(1995)
Transplantation
, vol.59
, pp. 670-673
-
-
Drazan, K.1
Wu, L.2
Shen, X.3
Bullington, D.4
Jurim, O.5
Busuttil, R.6
Shaked, A.7
-
19
-
-
0029956618
-
Gene therapy in lung transplantation: Feasibility of ex vivo adenovirus-mediated gene transfer to the graft
-
Chapelier A, Danel C, Mazmanian M, Bacha E, Sellak H, Gilbert M, Herve P, Lemarchand P. Gene therapy in lung transplantation: feasibility of ex vivo adenovirus-mediated gene transfer to the graft. Hum Gene Ther. 7:1996;1837-1845.
-
(1996)
Hum Gene Ther
, vol.7
, pp. 1837-1845
-
-
Chapelier, A.1
Danel, C.2
Mazmanian, M.3
Bacha, E.4
Sellak, H.5
Gilbert, M.6
Herve, P.7
Lemarchand, P.8
-
20
-
-
0030066351
-
Cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in transplanted mouse heart
-
Lee J, Laks H, Drinkwater D, Blitz A, Lam L, Shiraishi Y, Chang P, Drake T, Ardehlali A. Cardiac gene transfer by intracoronary infusion of adenovirus vector-mediated reporter gene in transplanted mouse heart. J Thorac Cardiovasc Surg. 111:1996;246-252.
-
(1996)
J Thorac Cardiovasc Surg
, vol.111
, pp. 246-252
-
-
Lee, J.1
Laks, H.2
Drinkwater, D.3
Blitz, A.4
Lam, L.5
Shiraishi, Y.6
Chang, P.7
Drake, T.8
Ardehlali, A.9
-
21
-
-
0030025064
-
Adenovirus-mediated gene delivery to the corneal endothelium
-
of special interest. An interesting preliminary study using adenoviral vectors to deliver genes to the corneal endothelium. The efficiency and kinetics of gene transfer were studied ex vivo. Gene transfer was found to be restricted to endothelial cells; expression of the reporter gene β-galactosidase could be detected for seven days. Importantly the function of the cornea was not affected by gene transfer
-
Larkin D, Oral H, Ring C, Lemoine N, George A. Adenovirus-mediated gene delivery to the corneal endothelium. of special interest Transplantation. 61:1996;363-370 An interesting preliminary study using adenoviral vectors to deliver genes to the corneal endothelium. The efficiency and kinetics of gene transfer were studied ex vivo. Gene transfer was found to be restricted to endothelial cells; expression of the reporter gene β-galactosidase could be detected for seven days. Importantly the function of the cornea was not affected by gene transfer.
-
(1996)
Transplantation
, vol.61
, pp. 363-370
-
-
Larkin, D.1
Oral, H.2
Ring, C.3
Lemoine, N.4
George, A.5
-
22
-
-
0028152937
-
Transforming growth factor β: The good, the bad and the ugly
-
Wahl S. Transforming growth factor β: the good, the bad and the ugly. J Exp Med. 180:1994;1587-1590.
-
(1994)
J Exp Med
, vol.180
, pp. 1587-1590
-
-
Wahl, S.1
-
23
-
-
0029858179
-
Comparison of adenovirus gene transfer to vascular endothelial cells in cell culture, organ culture and in vivo
-
of special interest. Disappointing results were obtained in this study when an adenovirus delivery system was used to express a reporter gene, β-galactosidase, in vascular endothelial cells in pieces of aorta from adult animals and human umbilical vein. The same construct was shown to be efficient at transferring the gene to endothelial cells in culture
-
Merrick A, Shewring L, Sawyer G, Gustafsson K, Fabre J. Comparison of adenovirus gene transfer to vascular endothelial cells in cell culture, organ culture and in vivo. of special interest Transplantation. 62:1996;1085-1089 Disappointing results were obtained in this study when an adenovirus delivery system was used to express a reporter gene, β-galactosidase, in vascular endothelial cells in pieces of aorta from adult animals and human umbilical vein. The same construct was shown to be efficient at transferring the gene to endothelial cells in culture.
-
(1996)
Transplantation
, vol.62
, pp. 1085-1089
-
-
Merrick, A.1
Shewring, L.2
Sawyer, G.3
Gustafsson, K.4
Fabre, J.5
-
24
-
-
0343813262
-
Safety and efficacy of in vivo transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors
-
Muhlhauser J, Jones M, Yamada I, Cirielli C, Lemarchand P, Gloe T, Bewig B, Signoretti S, Crystal R, Capogrossi M. Safety and efficacy of in vivo transfer into the porcine heart with replication-deficient, recombinant adenovirus vectors. Gene Ther. 3:1996;145-153.
-
(1996)
Gene Ther
, vol.3
, pp. 145-153
-
-
Muhlhauser, J.1
Jones, M.2
Yamada, I.3
Cirielli, C.4
Lemarchand, P.5
Gloe, T.6
Bewig, B.7
Signoretti, S.8
Crystal, R.9
Capogrossi, M.10
-
25
-
-
0027133238
-
Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo
-
Kass-Eisler A, Falck-Pederson E, Alvira M, Rivera J, Butterick P, Wittenberg B, Cipriani L, Leinwald L. Quantitative determination of adenovirus-mediated gene delivery to rat cardiac myocytes in vitro and in vivo. Proc Natl Acad Sci USA. 90:1993;11498-11502.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 11498-11502
-
-
Kass-Eisler, A.1
Falck-Pederson, E.2
Alvira, M.3
Rivera, J.4
Butterick, P.5
Wittenberg, B.6
Cipriani, L.7
Leinwald, L.8
-
26
-
-
0029874138
-
The NF-κB and IκB proteins: New discoveries and insights
-
of outstanding interest. A good recent review of NF-κB and its functions.
-
Baldwin A. The NF-κB and IκB proteins: new discoveries and insights. of outstanding interest Annu Rev Immunol. 14:1996;649-683 A good recent review of NF-κB and its functions.
-
(1996)
Annu Rev Immunol
, vol.14
, pp. 649-683
-
-
Baldwin, A.1
-
27
-
-
0029929722
-
A20 blocks endothelial cell activation through an NF-κB-dependent mechanism
-
of outstanding interest. An interesting approach based on the inhibition of NF-κB and designed to prevent endothelial cell activation.
-
Cooper J, Stroka D, Brostjan C, Palmetshofer A, Bach FH, Ferran C. A20 blocks endothelial cell activation through an NF-κB-dependent mechanism. of outstanding interest J Biol Chem. 271:1996;18068-18073 An interesting approach based on the inhibition of NF-κB and designed to prevent endothelial cell activation.
-
(1996)
J Biol Chem
, vol.271
, pp. 18068-18073
-
-
Cooper, J.1
Stroka, D.2
Brostjan, C.3
Palmetshofer, A.4
Bach, F.H.5
Ferran, C.6
-
28
-
-
12644256641
-
Prevention of hypoxic liver injury by in vivo transfection of the human bcl-2 gene
-
Yamabe K, Kamiike W, Shimizu S, Waguri S, Hasegawa J, Okuno S, Yohsioka Y, Sawa Y, Uchiyama Y, Matsuda H. Prevention of hypoxic liver injury by in vivo transfection of the human bcl-2 gene. Transplant Proc. 29:1997;384-385.
-
(1997)
Transplant Proc
, vol.29
, pp. 384-385
-
-
Yamabe, K.1
Kamiike, W.2
Shimizu, S.3
Waguri, S.4
Hasegawa, J.5
Okuno, S.6
Yohsioka, Y.7
Sawa, Y.8
Uchiyama, Y.9
Matsuda, H.10
-
29
-
-
0342271382
-
Gene therapy for donor hearts: Ex vivo liposome-mediated transfection
-
Dalesandro J, Akimoto H, Gorman C, McDonald T, Thomas R, Liggitt H, Allen M. Gene therapy for donor hearts: ex vivo liposome-mediated transfection. J Heart Lung Transplant. 15:1996;857-862.
-
(1996)
J Heart Lung Transplant
, vol.15
, pp. 857-862
-
-
Dalesandro, J.1
Akimoto, H.2
Gorman, C.3
McDonald, T.4
Thomas, R.5
Liggitt, H.6
Allen, M.7
-
30
-
-
0029913016
-
Molecular conjugate-mediated gene transfer into isolated human kidneys
-
Ziegler S, Kerby J, Curiel D, Diethelm A, Thompson J. Molecular conjugate-mediated gene transfer into isolated human kidneys. Transplantation. 61:1996;812-817.
-
(1996)
Transplantation
, vol.61
, pp. 812-817
-
-
Ziegler, S.1
Kerby, J.2
Curiel, D.3
Diethelm, A.4
Thompson, J.5
-
31
-
-
0030935124
-
Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet alograft survival
-
Gainer A, Korbutt G, Rajotte R, Warnock G, Elliott J. Expression of CTLA4-Ig by biolistically transfected mouse islets promotes islet alograft survival. Transplantation. 63:1997;1017-1021.
-
(1997)
Transplantation
, vol.63
, pp. 1017-1021
-
-
Gainer, A.1
Korbutt, G.2
Rajotte, R.3
Warnock, G.4
Elliott, J.5
-
32
-
-
0015433595
-
The effect of donor strain blood pretreatment on renal allograft rejection in rats
-
Fabre JW, Morris PJ. The effect of donor strain blood pretreatment on renal allograft rejection in rats. Transplantation. 14:1972;608-617.
-
(1972)
Transplantation
, vol.14
, pp. 608-617
-
-
Fabre, J.W.1
Morris, P.J.2
-
34
-
-
0027472414
-
Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene
-
Sykes M, Sachs DH, Nienhuis AW, Pearson DA, Moulton AD, Bodine DM. Specific prolongation of skin graft survival following retroviral transduction of bone marrow with an allogeneic major histocompatibility complex gene. Transplantation. 55:1993;197-202.
-
(1993)
Transplantation
, vol.55
, pp. 197-202
-
-
Sykes, M.1
Sachs, D.H.2
Nienhuis, A.W.3
Pearson, D.A.4
Moulton, A.D.5
Bodine, D.M.6
-
35
-
-
0029977235
-
Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: Relevance for a gene therapy approach to tolerance induction
-
of special interest. The investigation of nonmyeloablative protocols that will facilitate the engraftment of transduced bone marrow cells is important for the development of these strategies [34,35] for their future application in the induction of tolerance in clinical transplantation
-
Hayashi H, Le Guem C, Sachs D, Sykes M. Long-term engraftment of precultured post-5-fluorouracil allogeneic marrow in mice conditioned with a nonmyeloablative regimen: relevance for a gene therapy approach to tolerance induction. of special interest Transplant Immunol. 4:1996;86-90 The investigation of nonmyeloablative protocols that will facilitate the engraftment of transduced bone marrow cells is important for the development of these strategies [34,35] for their future application in the induction of tolerance in clinical transplantation.
-
(1996)
Transplant Immunol
, vol.4
, pp. 86-90
-
-
Hayashi, H.1
Le Guem, C.2
Sachs, D.3
Sykes, M.4
-
36
-
-
0023865253
-
Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes
-
Madsen JC, Superina RA, Wood KJ, Morris PJ. Immunological unresponsiveness induced by recipient cells transfected with donor MHC genes. Nature. 332:1988;161-164.
-
(1988)
Nature
, vol.332
, pp. 161-164
-
-
Madsen, J.C.1
Superina, R.A.2
Wood, K.J.3
Morris, P.J.4
-
37
-
-
0029954498
-
+ T cells in the induction of tolerance to class I molecules
-
of special interest. A study demonstrating that it is not necessary to expose the immune system to every donor MHC molecule to induce operational tolerance to an allograft in vivo
-
+ T cells in the induction of tolerance to class I molecules. of special interest Transplantation. 61:1996;1532-1538 A study demonstrating that it is not necessary to expose the immune system to every donor MHC molecule to induce operational tolerance to an allograft in vivo.
-
(1996)
Transplantation
, vol.61
, pp. 1532-1538
-
-
Saitovitch, D.1
Morris, P.2
Wood, K.3
-
38
-
-
0030903907
-
Retroviral gene transfer of a donor class I MHC gene to recipient bone marrow cells induces tolerances to alloantigens in vivo
-
of outstanding interest. Preliminary report of a strategy for the induction of operational tolerance to vascularised cardiac allografts in the mouse using recipient bone marrow cells expressing a donor MHC class I gene following retroviral gene transfer.
-
Wong W, Stranford S, Morris P, Wood K. Retroviral gene transfer of a donor class I MHC gene to recipient bone marrow cells induces tolerances to alloantigens in vivo. of outstanding interest Transplant Proc. 29:1997;1130 Preliminary report of a strategy for the induction of operational tolerance to vascularised cardiac allografts in the mouse using recipient bone marrow cells expressing a donor MHC class I gene following retroviral gene transfer.
-
(1997)
Transplant Proc
, vol.29
, pp. 1130
-
-
Wong, W.1
Stranford, S.2
Morris, P.3
Wood, K.4
-
39
-
-
0030922225
-
Pretransplant administration of a single donor class I MHC molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: Evidence for linked epitope suppression
-
of outstanding interest. An exploration of the mechanisms responsible for the survival of fully allogeneic grafts after host exposure to cells expressing only a single donor MHC molecule before transplantation.
-
Wong W, Morris P, Wood K. Pretransplant administration of a single donor class I MHC molecule is sufficient for the indefinite survival of fully allogeneic cardiac allografts: evidence for linked epitope suppression. of outstanding interest Transplantation. 63:1997;1490-1494 An exploration of the mechanisms responsible for the survival of fully allogeneic grafts after host exposure to cells expressing only a single donor MHC molecule before transplantation.
-
(1997)
Transplantation
, vol.63
, pp. 1490-1494
-
-
Wong, W.1
Morris, P.2
Wood, K.3
-
40
-
-
0031004407
-
Mechanisms of tolerance following class II gene transduction of autologous swine bone marrow
-
of outstanding interest. An exploration of the mechanisms responsible for the survival of fully allogeneic grafts after host exposure to cells expressing only a single donor MHC molecule before transplantation.
-
Yasamoto A, Yamada K, Sablinski T, LeGuern C, Sykes M, Sachs D. Mechanisms of tolerance following class II gene transduction of autologous swine bone marrow. of outstanding interest Transplant Proc. 29:1997;1132 An exploration of the mechanisms responsible for the survival of fully allogeneic grafts after host exposure to cells expressing only a single donor MHC molecule before transplantation.
-
(1997)
Transplant Proc
, vol.29
, pp. 1132
-
-
Yasamoto, A.1
Yamada, K.2
Sablinski, T.3
Leguern, C.4
Sykes, M.5
Sachs, D.6
-
41
-
-
0025092964
-
Induction of donor-specific unresponsiveness by intrathymic islet transplantation
-
Posselt AM, Barker CF, Tomaszewski JE, Markmann JF, Choti MA, Naji A. Induction of donor-specific unresponsiveness by intrathymic islet transplantation. Science. 249:1990;1293-1295.
-
(1990)
Science
, vol.249
, pp. 1293-1295
-
-
Posselt, A.M.1
Barker, C.F.2
Tomaszewski, J.E.3
Markmann, J.F.4
Choti, M.A.5
Naji, A.6
-
42
-
-
0029154674
-
Gene transfer to the thymus
-
De Matteo R, Raper S, Ahn M, Fisher K, Burke C, Radu A, Widera G, Claytor B, Barker C, Markmann J. Gene transfer to the thymus. Ann Surg. 222:1995;229-242.
-
(1995)
Ann Surg
, vol.222
, pp. 229-242
-
-
De Matteo, R.1
Raper, S.2
Ahn, M.3
Fisher, K.4
Burke, C.5
Radu, A.6
Widera, G.7
Claytor, B.8
Barker, C.9
Markmann, J.10
-
43
-
-
0029849639
-
Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats
-
of special interest. Intrathymic inoculation is an interesting approach to try and prevent the immune response to first generation adenoviral vectors
-
Ilan Y, Attavar P, Takahashi M, Davidson A, Horwitz M, Guida J, Chowdhury N, Chowdhury J. Induction of central tolerance by intrathymic inoculation of adenoviral antigens into the host thymus permits long-term gene therapy in Gunn rats. of special interest J Clin Invest. 98:1996;2640-2647 Intrathymic inoculation is an interesting approach to try and prevent the immune response to first generation adenoviral vectors.
-
(1996)
J Clin Invest
, vol.98
, pp. 2640-2647
-
-
Ilan, Y.1
Attavar, P.2
Takahashi, M.3
Davidson, A.4
Horwitz, M.5
Guida, J.6
Chowdhury, N.7
Chowdhury, J.8
-
44
-
-
0028226565
-
Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility
-
Knechtle S, Wang J, Jiao S, Geissler E, Sumimoto R, Wolff J. Induction of specific tolerance by intrathymic injection of recipient muscle cells transfected with donor class I major histocompatibility. Transplantation. 57:1994;990-996.
-
(1994)
Transplantation
, vol.57
, pp. 990-996
-
-
Knechtle, S.1
Wang, J.2
Jiao, S.3
Geissler, E.4
Sumimoto, R.5
Wolff, J.6
-
45
-
-
9544226448
-
A humanized system for pharmacologic control of gene expression
-
of outstanding interest. The ability to regulate the expression of genes transferred is critical if gene therapy is to be considered as a realistic approach for delivering therapeutic molecules in vivo. This study uses the immunosuppressive drug rapamycin to regulate gene expression in vivo.
-
Rivera V, Clackson T, Natesan S, Pollock R, Amara J, Keenan T, Magari S, Phillips T, Courage N, Cerasoli F, et al. A humanized system for pharmacologic control of gene expression. of outstanding interest Nat Med. 2:1996;1028-1032 The ability to regulate the expression of genes transferred is critical if gene therapy is to be considered as a realistic approach for delivering therapeutic molecules in vivo. This study uses the immunosuppressive drug rapamycin to regulate gene expression in vivo.
-
(1996)
Nat Med
, vol.2
, pp. 1028-1032
-
-
Rivera, V.1
Clackson, T.2
Natesan, S.3
Pollock, R.4
Amara, J.5
Keenan, T.6
Magari, S.7
Phillips, T.8
Courage, N.9
Cerasoli, F.10
|