Pharmacokinetic-based minibolus delivery as an alternative to continuous infusion for drugs that exhibit a biophase lag

Journal of Pharmacokinetics and Biopharmaceutics

Volumn 25, Issue 2, 1997, Pages 191-208

  Kern, Steven E ^a   Westenskow, Dwayne R ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Biophase models; Frequency response; Infusion pumps; Pharmacodynamics; Pharmacokinetics

Indexed keywords

NEUROMUSCULAR BLOCKING AGENT; PANCURONIUM;

COMPUTER SIMULATION; DRUG ADMINISTRATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFECT; HUMAN; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; SHORT SURVEY; STEADY STATE;

EID: 0030690152     PISSN: 0090466X     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1025732129798     Document Type: Short Survey

References (14)

1. D. R. Raemer, A. Buschman, J. R. Varvel, B. K. Philip, M. D. Johnson, D. A. Stein, and S. L. Shafer. The prospective use of population pharmacokinetics in a computer-driven infusion system for alfentanil. Anesthesiohgy 73:66-72 (1990).
2. J. Schuttler, S. Kloos, H. Schwilden, and H. Stoeckel. Total intravenous anaesthesia with propofol and alfentanil by computer-assisted infusion. Anaesthesia 43(supp):2-7 (1988).
3. J. B. Bovill and F. H. M. Engbers. Computers in anaesthesia. In Wylie and Churchill- Davidson (eds.), A Practice of Anesthesia, 6th ed., Edward Arnold, London, 1995, Chap. 26.
4. L. B. Sheiner, D. R. Stanski, S. Vozeh, R. D. Miller, and J. Ham. Simultaneous modeling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin. Pharmacol. Ther. 25:358-371 (1979).
5. J. M. Bailey and S. L. Shafer. A simple analytical solution to the three compartment pharmacokinetic model suitable for computer-controlled infusion pumps. IEEE Trans. Biomed. Eng. 38:522-525 (1991).
6. A. V. Hill. The possible effects of the aggregation of the molecules of haemoglobin on its dissociation curve. Proc. Physiol. Soc. Jan. 22: vi-vii (1910).
7. J. Schwartzenbach and K. F. Gill. System Modelling and Control, 3rd ed., Halsted Press, New York, 1992.
8. S. L. Shafer, S. E. Kern, and D. R. Stanski. The Scientific Basis of Infusion Techniques in Anesthesia, Bard MedSystems Division, North Reading, 1989.
9. S. E. Kern and D. R. Westenskow. Development of a closed-loop delivery system for neuromuscular blocking agents given in intensive care. Proc. IF AC Symp. Modelling and Control in Biomed. Sys. pp. 172-174 (1994).
10. S. M. Rupp, K. P. Castagnoli, D. M. Fisher, and R. M. Miller. Pancuronium and vecuronium pharmacokinetics and dynamics in younger and elderly adults. Anesthesiology 67:45- 49 (1987).
11. S. L Shafer and K. M. Gregg. Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J. Pharmacokin. Biopharm. 20:147-169 (1992).
12. M. Gibaldi, G. Levy, and H. Weintraub. Drug distribution and pharmacologic effects. Clin. Pharmacol. Ther. 12:734-742 (1971).
13. J. Norman, R. L. Katz, and R. F. Seed. The neuromuscular blocking action of pancuronium in man during anesthesia. Br. J. Anaesth 42:702-710 (1970).
14. P. Bragg, D. M. Fisher, J. Shi, F. Donati, C. Meistelma,. M. Lau, and L. B. Sheiner. Comparison of twitch depression of the adductor pollicis and respiratory muscles: Pharmacodynamic modeling without plasma concentrations. Anesthesiology 80:310-319 (1994).