Neoplastic transformation of the endocervix associated with downregulation of lactoferrin expression

Molecular Carcinogenesis

Volumn 20, Issue 2, 1997, Pages 240-250

  Farley, John ^a   Loup, Davonne ^a   Nelson, Myra ^a   Mitchell, Annette ^a   Esplund, Gretchen ^a   Macri, Charles ^a   Harrison, Charles ^a   Gray, Karen ^a  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

Author keywords

Adenocarcinoma in situ; Apoptosis; Lactoferrin; p53; Steroid hormone receptors

Indexed keywords

LACTOFERRIN; PROTEIN P53; STEROID RECEPTOR;

ADENOCARCINOMA; APOPTOSIS; ARTICLE; CARCINOMA IN SITU; EARLY DIAGNOSIS; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALIGNANT TRANSFORMATION; MICELLE; PRIORITY JOURNAL; PROTEIN SYNTHESIS REGULATION; RECEPTOR DOWN REGULATION; UTERINE CERVIX CARCINOMA; UTERINE ENDOCERVIX;

ADENOCARCINOMA; CELL DEATH; CELL DIVISION; CELL TRANSFORMATION, NEOPLASTIC; CERVIX UTERI; DOWN-REGULATION; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; LACTOFERRIN; NEOPLASM INVASIVENESS; PHENOTYPE; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RNA, MESSENGER; RNA, NEOPLASM; TUMOR SUPPRESSOR PROTEIN P53; UTERINE CERVICAL NEOPLASMS;

HUMAN PAPILLOMAVIRUS;

EID: 0030690035     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199710)20:2<240::AID-MC11>3.0.CO;2-A     Document Type: Article

References (32)

1. Boring CC. Cancer statistics. CA Cancer J Clin 44:7-26, 1994.
2. Hopkins MP, Morley GW. A comparison of adenocarcinoma and squamous cell carcinoma of the cervix. Obstet Gynecol 77:912-917, 1991.
3. Ferenczy A, Wright TC. Anatomy and histology of the cervix. In: R. J. Kurman (ed), Blaustein's Pathology of the Female Genital Tract. Springer-Verlag, New York, 1994, pp. 185-202.
4. Tenti P, Romagnoli S, Silini E, et al. Analysis and clinical implications of K-ras gene mutations and infection with human papillomavirus types 16 and 18 in primary adenocarcinoma of the uterine cervix. lnt J Cancer 64:9-13, 1995.
5. Mullokandov MR, Kholodilov NG, Atkin NB, Burk RD, Johnson AB, Klinger HP. Genomic alterations in cervical carcinoma: Losses of chromosome heterozygosity and human papilloma virus tumor status. Cancer Res 56:197-205, 1996.
6. Tervahauta A, Syrjanen S, Syrjanen K. Epidermal growth factor receptor, c-erbB-2 proto-oncogene and estrogen receptor expression in human papilloma virus lesions of the uterine cervix. lnt J Gynecol Pathol 12:234-240, 1994.
7. Shikano K, Sasano H, lto K, et al. The correlation between HPV infection and cell proliferative activity in uterine cervical adenocarcinoma J Exp Med 169:279-288, 1993.
8. Samaratunga H, Cox N, Wright RG. Human papillomavirus DNA in glandular lesions of the uterine cervix. J Clin Pathol 46:718-721, 1993.
9. Yokoyama M, Tsutsumi K, Pater A, Pater MM. Human papillomavirus 18-immortalized endocervical cell with in vitro cytokeratin expression characteristics of adenocarcinomas. Obstet Gynecol 83:197-204, 1994.
10. Walmer DK, Wrona MA, Hughes CL, Nelson KG. Lactoferrin expression in the mouse reproductive tract during the natural estrous cycle: Correlation with circulating estradiol and progesterone. Endocrinology 131:1458-1466, 1992.
11. Walmer DK, Padin CJ, Wrona MA, et al. Malignant transformation of the human endometrium is associated with overexpression of lactoferrin messenger RNA and protein. Cancer Res 55: 1168-1175, 1995.
12. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 1989.
13. Rejman JJ, Oliver SP, Muenchen RA, Turner JD. Proliferation of the MAC-T bovine mammary epithelial cell line in the presence of mammary secretions whey proteins. Cell Biology International Reports 16:993-1001, 1992.
14. Broxmeyer HE. Suppressor cytokines and regulation of myelopoiesis. Biology and possible clinical uses. American Journal of Pediatric Hematology-Oncology 14:22-30, 1992.
15. Sanchez L, Calvo M, Brock JH. Biological role of lactoferrin. Arch Dis Child 67:657-661, 1992.
16. Furmanski P, Li ZP, Fortuna MB, Swamy CV, Das MR. Multiple molecular forms of human lactoferrin: Identification of a class of lactoferrins that possess ribonuclease activity and lack iron binding capacity. J Exp Med 170:415-429, 1989.
17. D'Alessio G, DiDonato A, Parente A, Piccoli R. Seminal RNase: A unique member of the ribonuclease superfamily. Trends Biochem Sci 16:104-106, 1991.
18. He J, Furmanski P. Sequence specificity and transcriptional activation in the binding of lactoferrin to DNA. Nature 373:721-724, 1995.
19. Rey MW, Woloshuk SL, deBoer HA, Pieper FR. Complete nucleotide sequence of human mammary gland lactoferrin. Nucleic Acids Res 18:5288, 1990.
20. Levay PF, Viljoen M. Lactoferrin: A general review. Haematologica 80:252-267, 1995.
21. Yang N, Shigeta H, Shi H, Teng C. Estrogen related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. J Biol Chem 271:5795-5804, 1996.
22. Campbell T, Skilton RA, Coombes RC, Shousha S, Graham MD, Luqmani YA. Isolation of lactoferrin cDNA clone and its expression in human breast cancer. Br J Cancer 65:19-26, 1992.
23. Panella TJ, Liu Y, Huang AT, Teng CT. Polymorphism and altered methylation of the lactoferrin gene in normal leukocytes, leukemic cells, and breast cancer. Cancer Res 51:3037-3043, 1991.
24. Konishi I, Fujii S, Nonogaki H, Nanbu Y, Iwai T, Mori T. Immunohistochemical analysis of estrogen receptors, progesterone receptors, Ki-67 antigen, and human papillomavirus DNA in normal and neoplastic epithelium of the uterine cervix. Cancer 68:1340-1350, 1991.
25. Punnonen R, Mattila J, Kuoppala T, Koivula T. DNA ploidy, cell proliferation and steroid hormone receptors in endometrial hyperplasia and early adenocarcinoma. J Cancer Res Clin Oncol 119:426-429, 1993.
26. Masood S, Rhatigan RM, Wildinson EW, Barwick KW, Wilson WJ. Expression and prognostic significance of estrogen and progesterone receptors in adenocarcinoma of the uterine cervix. Cancer 72:511-518, 1993.
27. Ehrlich C, Young P, Stehman F, Sutton G, Alford W. Steroid receptors and clinical outcome in patients with adenocarcinoma of the endometrium. Am J Obstet Gynecol 58:796-807, 1988.
28. Li S-F, Shiozawa T, Nakayama K, Nikaido T, Fuijii S. Stepwise abnormality of sex steroid hormone receptors, tumor suppressor gene products (p53 and Rb), and cyclin E in uterine endometrioid carcinoma. Cancer 77:321-329, 1996.
29. Jiko K, Tsuda H, Sato S, Hirohashi S. Pathogenetic significance of p53 and c-Ki-ras gene mutations and human papillomavirus DNA integration in adenocarcinoma of the uterine cervix and uterine isthmus. Int J Cancer 59:601-506, 1994.
30. Dtreet D, Delgado G. The role of p53 and HPV in cervical cancer. Gynecol Oncol 58:287-288, 1995.
31. Mittal KR, Lin O, Chan W, Goswami S, Demopoulos RI. Cervical squamous dysplasias and carcinomas with immunodetectable p53 frequently contain HPV. Gynecol Oncol 58: 289-294, 1995.
32. Korsmeyer SJ, Shutter JR, Veis DJ, Merry DE, Oltvai ZN. Bcl-2/ Bax: A rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 4:327-332, 1993.