Nuclear RNA accumulations contain released transcripts and exhibit specific distributions with respect to Sm antigen foci

DNA and Cell Biology

Volumn 16, Issue 10, 1997, Pages 1133-1142

  Lampel, S ^a   Bridger, J M ^a   Zirbel, R M ^a   Mathieu, U R ^a   Lichter, P ^a,b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b Abteilung Organisation Komplexer Genome   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; HEAT SHOCK PROTEIN; MEMBRANE ANTIGEN; NUCLEAR RNA;

ANIMAL CELL; ARTICLE; BASEMENT MEMBRANE; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; EPSTEIN BARR VIRUS; GENE LOCUS; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; RNA SPLICING; RNA TRANSCRIPTION; SIGNAL TRANSDUCTION; WART VIRUS;

ANIMALIA; HUMAN HERPESVIRUS 4; HUMAN PAPILLOMA VIRUS; HUMAN PAPILLOMAVIRUS TYPES; MAMMALIA;

EID: 0030690003     PISSN: 10445498     EISSN: None     Source Type: Journal    
DOI: 10.1089/dna.1997.16.1133     Document Type: Article

References (46)

1. AUSTIN, P.J., FLEMINGTON, E., YANDAVA, C.N., STROMINGER, J.L., and SPECK, S. (1988). Complex transcription of Epstein-Barr virus BamHI fragment H rightward open reading frame 1 (BHRF1) in latently and lytically infected B lymphocytes. Proc. Natl. Acad. Sci. USA 85, 3678-3682.
2. BEREZNEY, R. (1991). The nuclear matrix: A heuristic model for investigating genomic organization and function in the cell nucleus. J. Cell. Biochem. 47, 109-123.
3. BERMAN, S.A., BURSZTAJN, S., BOWEN, B., and GILBERT, W. (1990). Lòcalization of an acetylcholine receptor intron to the nuclear membrane. Science 247, 212-214.
4. BOND, U. (1988). Heat shock but not other stress inducers leads to the disruption of a sub-set of sn-RNPs and inhibition of in vitro splicing in HeLa cells. EMBO J. 7, 3509-3518.
5. BRIDGER, J.M., LAMPEL, S., and LICHTER, P. (1997). In situ hybridization. In Cells, D. Spector, R. Goldman, and L. Leinwand, eds. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY) (in press).
6. CARTER, K.C., TANEJA, K.L., and LAWRENCE, J.B. (1991). Discrete nuclear domains of poly(A)RNA and their relationship to the functional organization of the nucleus. J. Cell Biol. 115, 1191-1202.
7. CARTER, K.C., BOWMAN, D., CARRINGTON, W., FOGARTY, K., MCNEIL, J.A., FAY, F.S., and LAWRENCE, J.B. (1993). A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science 259, 1330-1335.
8. COVERLEY, D., and LASKEY, R.A. (1994). Regulation of eukaryotic DNA replication. Annu. Rev. Biochem. 63, 745-776.
9. CREMER, T., KURZ, A., ZIRBEL, R., DIETZEL, S., RINKE, B., SCHRÖCK, E., SPEICHER, M.R., MATHIEU, U., JAUCH, A., EMMERICH, P., SCHERTHAN, H., RIED, T., CREMER, C., and LICHTER, P. (1993). The role of chromosome territories in the functional compartmentalization of the cell nucleus. Cold Spring Harbor Symp. Quant. Biol. 58, 777-792.
10. DIRKS, R.W., DANIEL, K.C., and RAAP, A.K. (1995). RNAs radiate from gene to cytoplasm as revealed by fluorescence in situ hybridization. J. Cell Sci. 108, 2565-2572.
11. DÜRST, M., CROCE, C.M., GISSMANN, L., SCHWARZ, E., and HUEBNER, K. (1987). Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas. Proc. Natl. Acad. Sci. USA 84, 1070-1074.
12. FAKAN, S., LESER, G., and MARTIN, T.E. (1986). Immunoelectron microscope visualisation of nuclear ribonucleoprotein antigens within spread transcription complexes. J. Cell Biol. 103, 1153-1157.
13. FEY, E.G., KROCHMALNIC, G., and PENMAN, S. (1986). The nonchromatin substructures of the nucleus: The ribonucleoprotein (RNP)-containing and RNP-depleted matrices analyzed by sequential fractionation and resinless section electron microscopy. J. Cell Biol. 102, 1654-1665.
14. FISCHER, U., HUBER, J., BOELENS, W.C., MATTAJ, I.W., and LÜHRMANN, R. (1995). The HIV-Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAs. Cell 82, 475-483.
15. GALL, J.G., TSVETKOV, A., WU, Z.A., and MURPHY, C. (1995). Is the sphere organelle coiled body a universal nuclear component. Dev. Genet. 16, 25-35.
16. GREENBERG, M.E., and ZIFF, E.B. (1984). Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311, 433-438.
17. HE, D.C., MARTIN, T., and PENMAN, S. (1991). Localization of heterogeneous nuclear ribonucleoprotein in interphase nuclear matrix core filaments and on perichromosomal filaments at mitosis. Proc. Natl. Acad. Sci. USA 88, 7469-7443.
18. HOFFMANN, T., and HOVEMANN, B. (1988). Heat-shocked Hsp84 and Hsp86, of mice and men: Two related genes encode formerly identified tumour-specific transplantation antigens. Gene 74, 491-501.
19. HUANG, S., and SPECTOR, D.L. (1991). Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors. Genes & Dev. 5, 2288-2302.
20. HUANG, S., DEERINK, T., ELLISMAN, M., and SPECTOR, D. (1994). In vivo analysis of the stability and transport of nuclear poly(a)+RNA. J. Cell. Biol. 126, 877-899.
21. JACKSON, D.A., HASSAN, A.B., ERRINGTON, R.J., and COOK, P.R. (1993). Visualization of focal sites of transcription within human nuclei. EMBO J. 12, 1059-1065.
22. JIMÉNEZ-GARCIA, L.F., and SPECTOR, D.L. (1993). In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism. Cell 73, 47-59.
23. KRAMER, J., ZACHAR, Z., and BINGHAM, P. (1994). Nuclear pre-mRNA metabolism: Channels and tracks. Trends Cell Biol. 4, 35-37.
24. KURZ, A., LAMPEL, S., NICKOLENKO, J.E., BRADL, J., BENNER, A., ZIRBEL, R.M., CREMER, T., and LICHTER, P. (1996). Active and inactive genes localize preferentially in the periphery of chromosome territories. J. Cell Biol. 135, 1195-1205.
25. LAMOND, A.I., and CARMO-FONSECA, M. (1993). The coiled body. Trends Cell Biol. 3, 198-204.
26. LANGER, P.R., WALDROP, A.A., and WARD, D.C. (1981). Enzymatic synthesis of biotin-labeled polynucleotides: Novel nucleic acid affinity probes. Proc. Natl. Acad. Sci. USA 78, 6633-6637.
27. LAWRENCE, J.B., VILLNAVE, C.A., and SINGER, R.H. (1988). Interphase chromatin and chromosome gene mapping by fluorescence detection of in situ hybridization reveals the presence and orientation of two closely integrated copies of EBV in a human lymphoblastoid cell line. Cell 52, 51-61.
28. LAWRENCE, J.B., SINGER, R.H., and MARSELLE, L.M. (1989). Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization. Cell 57, 493-502.
29. LERNER, E.A., LERNER, M.R., JANEWAY, J.C.A., and STEITZ, J.A. (1981). Monoclonal antibodies to nucleic acid-containing cellu-lar constituents: Probes for molecular biology and autoimmune disease. Proc. Natl. Acad. Sci. USA 78, 2737-2741.
30. LONG, M.R., HUANG, C.H., and POGO, A.O. (1979). Isolation and characterization of the nuclear matrix in friend erythroleukemia cells: Chromatin and hnRNA interactions with the nuclear matrix. Cell 18, 1079-1090.
31. MATTAJ, I.W. (1994). Splicing in space. Nature 372, 727-728.
32. MILLER, O.L., and HAMKALO, B.A. (1972). Visualization of RNA synthesis on chromosomes. Int. Rev. Cytol. 33, 1-25.
33. POLAK, A., HARTL, G., ZIMBER, U., FREESE, U.K., LAUX, G., TAKAKI, K., HOHN, B., GISSMANN, L., and BORNKAMM, G.W. (1984). A complete set of overlapping cosmid clones of MABA virus derived from nasopharyngeal carcinoma and its similarity to other Epstein-Barr virus isolates. Gene 27, 279-288.
34. RAPP, A.K., VAN DE RIJKE, F.M., DIRKS, R.W., SOL, C.J., BOOM, R., and VAN DER PLOEG, M. (1991). Bicolor fluorescence in situ hybridization to intron and exon mRNA sequences. Exp. Cell Res. 197, 319-322.
35. ROGGENBUCK, B., LARSEN, P.M., FEY, S.J., BARTSCH, D., GISSMANN, L., and SCHWARZ, E. (1991). Human papillomavirus type 18 E6*, E6, and E7 protein synthesis in cell-free translation systems and comparison of E6 and E7 in vitro translation products to proteins immunoprecipitated from human epithelial cells. J. Virol. 65, 5068-5072.
36. SASS, H., and PEDERSON, T. (1984). Transcription-dependent localization of U1 and U2 small nuclear ribonucleoproteins at major sites of gene activity in polytene chromosomes. J. Mol. Biol. 180, 911-926.
37. SCHNEIDER-GÄDICKE, A., and SCHWARZ, E. (1986). Different human cervical carcinoma cell show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J. 5, 2285-2292.
38. SHUKLA, R.R., DOMINSKI, Z., ZWIERZYNSKI, T., and KOLE R. (1990). Inactivation of splicing factors in HeLa cells subjective to heat shock. J. Biol. Chem. 265, 20377-20383.
39. WANG, J., CAO, L-G., WANG, Y.-L., and PEDERSON, T. (1991). Localization of pre-messenger RNA at discrete nuclear sites. Proc. Natl. Acad. Sci. USA 88, 7391-7395.
40. WANSINK, D.G., SCHUL, W., VAN DER KRAAN, I., VAN STEENSEL, B., VAN DRIEL, R., and DE JONG, L. (1993). Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus. J. Cell Biol. 122, 283-293.
41. XING, Y., and LAWRENCE, J.B. (1991). Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation. J. Cell Biol. 112, 1055-1063.
42. XING, Y., JOHNSON, C.V., DOBNER, P.R., and LAWRENCE, J.B. ( 1993). Higher level organization of individual gene transcription and RNA splicing. Science 259, 1326-1330.
43. XING, Y., JOHNSON, C.V., MOEN, P.T., MCNEIL, J.A., and LAWRENCE, J.B. (1995). Nonrandom gene organization: structural arrangement of specific pre-mRNA transcription and splicing with SC-35 domains. J. Cell Biol. 131, 1635-1647.
44. ZACHAR, Z., KRAMER, J., MIMS, I., and BINGHAM, P. (1993). Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans. J. Cell Biol. 121, 729-742.
45. ZHANG, G., TANEJA, K.L., SINGER, R.H., and GREEN, M.R. (1994). Localization of pre-mRNA splicing in mammalian nuclei. Nature 372, 809-812.
46. ZIRBEL, R.M., MATHIEU, U.R., KURZ, A., CREMER, T., and LICHTER, P. (1993). Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries. Chrom. Res. 1, 93-106.