Antidepressants restore hypothalamic-pituitary-adrenal feedback function in aged, cognitively-impaired rats

Neurobiology of Aging

Volumn 18, Issue 5, 1997, Pages 527-533

  Rowe, W ^a   Steverman, A ^a   Walker, M ^a   Sharma, S ^a   Barden, N ^c   Seckl, J R ^b   Meaney, M J ^b  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c NONE

Author keywords

Adrenocorticotropin; Aging; Cognition; Desipramine; Glucocorticoid negative feedback

Indexed keywords

CORTICOTROPIN; DESIPRAMINE; GLUCOCORTICOID RECEPTOR;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; CORTICOSTEROID BLOOD LEVEL; DRUG EFFECT; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENOCORTICOTROPIC HORMONE; AGING; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; COGNITION DISORDERS; CORTICOSTERONE; DESIPRAMINE; FEEDBACK; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MAZE LEARNING; PITUITARY-ADRENAL SYSTEM; RADIOIMMUNOASSAY; RATS;

EID: 0030687621     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0197-4580(97)00103-6     Document Type: Article

References (59)

1. Antoni F. A. Hypothalamic control of adrenocorticotropin secretion Advances since the discovery of 41-residue corticotropin-releasing factor . Endocr. Rev. 7:1986;351-378.
2. Badgy G., Chrousos G. P., Calagero A. E. Circadian patterns of plasma immunoreactive corticotropin, beta-endorphin, corticosterone and prolactin after immunoneutralization of corticotropin-releasing hormone. Neuroendocrinology. 53:1991;573-578.
3. Bentson J., Reza M., Winter J., Wilson G. Steroids and apparent cerebral atrophy on computed tomography scans. J. Comput. Assisted Tomogr. 2:1978;16-23.
4. Bergstrom D. A., Kellar K. J. Adrenergic and serotonergic receptor binding after chronic desmethylimipramine treatment. J. Pharmacol. Exp. Ther. 209:1979;256-261.
5. Bodnoff S. R., Humphreys A., Lehman J., Diamond D. M., Rose G. M., Meaney M. J. Elevated glucocorticoid levels produce spatial memory deficits, dampened long-term potentiation, and enhanced hippocampal neuron loss in mid-aged rats. J. Neuroscience. 15:1995;61-69.
6. Brady L., Whitfield H. W. Jr, Fox R., Gold P. W., Herkenham M. Antidepressant drugs regulate corticotropin-releasing factor and tyrosine hydroxylase messenger RNAs in rat brain. J. Clin. Invest. 87:1991;831-837.
7. Brady L. S., Gold P. W., Herkenham M., Lynn A. B., Whitfield H. J. Jr. The antidepressants fluoxetine, idazoxan and phenelzine alter corticotropin-releasing hormone and tyrosine hydroxylase mRNA levels in rat brain; therapeutic implications. Brain Res. 572:1992;117-125.
8. Chrousos G. P., Gold P. W. The concepts of stress and stress system disorders. JAMA. 267:1992;1244-1252.
9. Dallman M. F., Akana S. F., Cascio C. S., Darlington D. N., Jacobson L., Levin N. Regulation of ACTH secretion Variations on a theme of B . Rec. Prog. Hormone Res. 43:1987;113-173.
10. De Kloet E. R. Brain corticosteroid receptor balance and homeostatic control. Fron. Neuroendocrinology. 12:1991;95-164.
11. Diamond D. M., Bennett M. C., Fleshner M., Rose G. M. Inverted-U relationship between the level of peripheral corticosterone and the magnitude of hippocampal primed burst potentiation. Hippocampus. 2:1992;421-430.
12. Gaillard R. C., Riondel A., Muller A. F. RU486 A steroid with antiglucocorticosteroid activity that only disinhibits the human pituitary-adrenal system at a specific time of day . Proc. Natl. Acad. Sci. USA. 81:1984;841-851.
13. Greist J. H., Greist T. H. Antidepressant Treatment - The Essentials. 1979;Williams and Wilkins, Baltimore.
14. Hauger R. L., Thrivikraman K. V., Plotsky P. M. Age-related alterations of hypothalamic-pituitary-adrenal axis function in male Fischer 344 rats. Endocrinology. 134:1994;1528-1536.
15. Hillhouse E. W., Jones M. T. Effect of bilateral adrenalectomy and corticosteroid therapy on the secretion of corticotrophin-releasing factor activity from the hypothalamus of the rat in vitro. J. Endocrinol. 71:1976;21-30.
16. Imaki T., Nahan J.-L., Rivier C., Sawchenko P. E., Vale W. Differential regulation of corticotropin-releasing factor mRNA in rat brain regions by glucocorticoids and stress. J. Neuroscience. 11:1991;585-599.
17. Issa A. M., Rowe W., Gauthier S., Meaney M. J. Hypothalamic-pituitary-adrenal activity in aged, cognitively impaired and cognitively-unimpaired rats. J. Neuroscience. 10:1990;3247-3254.
18. Jacobson L., Sapolsky R. M. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenal axis. Endocr. Rev. 12:1991;118-133.
19. Joels M., de Kloet E. R. Effects of glucocorticoids and norepinephrine on the excitability in the hippocampus. Science. 245:1989;1502-1505.
20. Kerr D. S., Campbell L. W., Applegate M. D., Brodish A., Landfield P. W. Chronic stress-induced acceleration of electrophysiologic and morphometric biomarkers of hippocampal aging. J. Neuroscience. 11:1991;1316-1324.
21. Kerr D. S., Campbell L. W., Hao S.-Y., Landfield P. W. Corticosteroid modulation of hippocampal potentials Increased effect with aging . Science. 245:1989;1502-1505.
22. Krey L. C., Lu K., Butler W., Hotchkiss J., Piva F., Knobil E. Surgical disconnections of the medial basal hypothalamus and pituitary function in the rhesus monkey II. GH and cortisol secretion . Endocrinology. 96:1975;1088-1093.
23. Landfield P. W., Pitler T. A. Prolonged Ca-dependent after-hyperpolarizations in hippocampal neurons of the aged rat. Science. 226:1984;1089-1092.
24. Lupien S., Lecours A. R., Lussier I., Schwartz G., Nair N. P. V., Meaney M. J. Basal cortisol levels and cognitive deficits in human aging. J. Neuroscience. 14:1994;2893-2903.
25. Lupien, S.; LeCours, A. R.; Schwartz, G.; Sharma, S.; Nair, N. P. V.; Meaney, M. J. Neuropsychological assessment of healthy elderly subjects in relation to basal cortisol activity. J. Neuroscience, In press.
26. Martgnoni E., Costa A., Sinforiani E., Luizzi A., Chiodini P., Mauri M., Bono G., Nappi G. The brain as a target for adrenocortical steroids Cognitive implications . Psychoneuroendocrinology. 17:1992;343-354.
27. Meaney M. J., Aitken D. H., Bhatnagar S., Ch. van Berkel C., Sapolsky R. M. Postnatal handling attenuates neuroendocrine, anatomical and cognitive impairments related to the aged hippocampus. Science. 238:1988;766-768.
28. Meaney M. J., Aitken D. H., Sharma S., Viau V. Basal ACTH, corticosterone, and corticosterone-binding globulin levels over the diurnal cycle, and hippocampal type I and type II corticosteroid receptors in young and old, handled and non-handled rats. Neuroendocrinology. 55:1992;204-213.
29. Meaney M. J., Viau V., Bhatnagar S., Aitken D. H. Occupancy and translocation of hippocampal glucocorticoid receptors during and following stress. Brain Res. 445:1988;198-203.
30. Meaney M. J., Viau V., Bhatnagar S., Betito K., Iny L. J., Mitchell J. B. Cellular mechanisms underlying the development and expression of individual differences in the hypothalamic-pituitary-adrenal stress response. J. Steroid Biochem. Mol. Biol. 39:1991;265-274.
31. Mitchell J. B., Betito K., Rowe W., Boksa P., Meaney M. J. Serotonergic regulation of type II corticosteroid receptor binding in cultured hippocampal cells The role of serotonin-induced increases in cAMP levels . Neuroscience. 48:1992;631-639.
32. Mitchell J. B., Rowe W., Boksa P., Meaney M. J. Serotonin regulates type II corticosteroid receptor binding in hippocampal cell cultures. J. Neuroscience. 10:1990;1524-1533.
33. Morris R. G. M., Garrard P., Rawlins J. N. P., O'Keefe J. Place navigation is impaired in rats with hippocampal lesions. Nature. 297:1982;681-683.
34. Nasman B., Olsson T., Viitanen M., Carlstrom K. A subtle disturbance in the feedback regulation of the hypothalamic-pituitary-adrenal axis in the early phase of Alzheimer's disease. Psychoneuroendocrinology. 20:1995;211-220.
35. Owens M. J., Nemeroff C. B. Physiology and pharmacology of corticotropin-releasing factor. Pharm. Rev. 43:1991;425-473.
36. Peiffer A., Veilleux S., Barden N. Antidepressant and other centrally-acting drugs regulate glucocorticoid receptor mRNA levels in the rat brain. Psychoneuroendocrinology. 16:1991;505-515.
37. Pepin M. C., Barden N. Decreased glucocorticoid receptor activity following glucocorticoid receptor antisense RNA gene fragment transfection. Mol. Cell. Biol. 11:1991;1647-1655.
38. Pepin M. C., Govindan M. V., Barden N. Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Mol. Pharmacol. 41:1992;1016-1022.
39. Pepin M. C., Pothier F., Barden N. Impaired type II glucocorticoid receptor function in mice bearing antisense RNA transgene. Nature. 355:1992;725-728.
40. Plotsky P. M., Otto S., Sapolsky R. M. Inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation by delayed glucocorticoid feedback. Endocrinology. 119:1986;1126-1130.
41. Plotsky P. M., Sawchenko P. E. Hypophysial-portal plasma levels, median eminence content and immunohistochemical staining of corticotropin releasing factor, arginine vasopressin and oxytocin following pharmacological adrenalectomy. Endocrinology. 120:1987;1361-1369.
42. Plotsky P. M., Vale W. Hemorrhage-induced secretion of corticotropin-releasing factor. Endocrinology. 114:1984;164-169.
43. Przegalinski E., Budziszewska B. The effect of long-term treatment with antidepressant drugs on the hippocampal mineralocorticoid and glucocorticoid receptors in rats. Neurosci. Lett. 161:1993;215-218.
44. Reul J. M. H. S., Stec I., Soder M., Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology. 133:1993;312-320.
45. Rubinow D. R., Post R. M., Savardand R., Gold P. M. Cortisol hypersecretion and cognitive impairment in depression. Arch. Gen. Psychiatry. 41:1984;279-283.
46. Sapolsky R. M. Do glucocorticoid levels rise with age in the rat? Neurobiol. Aging. 13:1991;171-176.
47. Sapolsky R. M., Krey L. C., McEwen B. S. Prolonged glucocorticoidexposure reduces hippocampal neuron number Implication for aging . J. Neuroscience. 5:1985;1222-1227.
48. Sarrieau A., Rowe W., O'Donnell D., LaRocque S., Nair N. P. V., Levin N., Seckl J. R., Meaney M. J. Hypothalamic-pituitary-adrenal activity and corticosteroid receptor expression in aged, cognitively-impaired and cognitively-unimpaired rats. Soc. Neuroscience Abst. 18:1992;669.
49. Seckl J. R., Fink G. Antidepressants increase glucocorticoid and mineralocorticoid receptor mRNA expression in rat hippocampus in vivo. Neuroendocrinology. 55:1992;621-626.
50. Sharma M., Palacios-Bois J., Schwartz G., Quirion R., Nair N. P. V. Circadian rhythms of malatonin and cortisol in aging. Biol. Psychiatry. 25:1989;305-319.
51. Sherman B., Wysham C., Pfohl B. Age-related changes in the circadian rhythm of plasma cortisol in man. J. Clin. Endo. Metab. 61:1985;439-443.
52. Starkman M. N., Gebarski S. S., Berent S., Scheingart D. E. Hippocampal formation volume, memory dysfunction, and cortisol levels. Biol. Psychiatry. 32:1992;756-765.
53. Varney N. R., Alexander B., MacIndoe J. H. Reversible steroid dementia in patients without steroid psychosis. Am. J. Psychiatry. 141:1984;369-372.
54. Vedder H., Weiss I., Holsboer F., Reul J. M. H. M. Glucocorticoid and mineralocorticoid receptors in rat neocortical and hippocampal brain cells in culture Characterization and regulatory studies . Brain Res. 605:1993;18-24.
55. Walker C-D., Akana S. F., Cascio C. S., Dallman M. F. Adrenalectomy in the neonate; Adult-like adrenocortical system responses to both removal and replacement of corticosterone. Endocrinology. 127:1990;832-842.
56. West C. D., Brown H., Simon E. L., Carter D. B., Kumagai L. F., Englert E. Adrenocortical function and cortisol metabolism in old age. J. Clin. Endo. Metab. 21:1961;1197-1207.
57. Whelan T. B., Schteingart D. E., Starkman M. N., Smith A. Neuropsychological deficits in Cushing's Syndrome. J. Nerv. Ment. Dis. 168:1980;753-757.
58. Wolkowitz O. M., Reus V. I., Weingartner H., Thompson K., Breier A., Doran A., Rubinow D., Pickar D. Cognitive effects of corticosteroids. Am. J. Psychiatry. 147:1990;1297-1303.
59. Wolkowitz O. M., Weingartner H., Rubinow D. R., Jimerson D., Kling M., Berretini W., Thompson K., Breier A., Doran A., Reus V. I., Pickar D. Steroid modulation of human memory Biochemical correlates . Biol. Psychiat. 33:1993;744-746.