Pathogenic antibodies inhibit the binding of apolipoproteins to megalin/gp330 in passive Heymann nephritis

Journal of Clinical Investigation

Volumn 100, Issue 9, 1997, Pages 2303-2309

  Kerjaschki, Dontscho ^a   Exner, Markus ^a   Ullrich, Robert ^a   Susani, Martin ^a   Curtiss, Linda K ^d   Witztum, Joseph L ^c   Farquhar, Marilyn Gist ^b   Orlando, Robert A ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Apolipoprotein; Heymann nephritis; Lipid peroxidation; Megalin gp330

Indexed keywords

APOLIPOPROTEIN B; APOLIPOPROTEIN B100; APOLIPOPROTEIN E; AUTOANTIBODY; CELL RECEPTOR; IMMUNOGLOBULIN G; MEGALIN; UNCLASSIFIED DRUG; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GLOMERULUS BASEMENT MEMBRANE; HEYMANN NEPHRITIS; HYPERLIPIDEMIA; IMMUNE COMPLEX DEPOSITION; INTERNALIZATION; LIPID PEROXIDATION; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; RAT;

EID: 0030685742     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119768     Document Type: Article

References (37)

1. Schwartz, M.M. 1992. Membranous glomerulonephritis. In Pathology of the Kidney. R.H. Hepinstall, editor. Little, Brown and Company, Boston/Toronto/London. 559-626.
2. Schöndorff, D., U. Dendorfer, V. Brumberger, and C. Keunecke. 1995. Limitations of therapeutic approaches to glomerular diseases. Kidney Int. 50: S19-S25.
3. Heymann, W., D.B. Hackel, S. Harwood, S.G.F. Wilson, and J.L.P. Hunter. 1959. Production of the nephrotic syndrome in rats by Freund's adjuvants and rat kidney suspensions. Proc. Soc. Exp. Biol. Med. 100:660-664.
4. Cavallo, T. 1994. Membranous nephropathy. Insights from Heymann nephritis. Am. J. Pathol. 144:651-658.
5. Kerjaschki, D., and T.J. Neale. 1996. Molecular mechanisms of glomerular injury in rat experimental membranous nephropathy (Heymann nephritis). J. Am. Soc. Nephrol. 7:2518-2526.
6. Farquhar, M.G., D. Kerjaschki, M. Lundstrom, and R.A. Orlando. 1994. gp330 and RAP: the Heymann nephritis antigenic complex. Ann. NY Acad. Sci. 737:96-113.
7. Saito, A., S. Pietromonaco, A.K. Loo, and M.G. Farquhar. 1994. Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. Proc. Natl. Acad. Sci. USA. 91:9725-9729.
8. Raychowdhury, R., J.L. Niles, R.T. McCluskey, and J.A. Smith. 1989. Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor. Science (Wash. DC). 244:1163-1165.
9. Stefansson, S., D.A. Chappell, K.M. Argraves, D.K. Strickland, and W.S. Argraves. 1995. Glycoprotein 330/low density lipoprotein receptor-related protein-2 mediates endocytosis of low density lipoproteins via interaction with apolipoprotein B100. J. Biol. Chem. 270:19417-19421.
10. Willnow, T.E., J.L. Goldstein, K. Orth, M.S. Brown, and J. Herz. 1992. Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance. J. Biol. Chem. 267:26172-26180.
11. Exner, M., M. Susani, J.L. Witztum, A. Hovorka, L.K. Curtiss, S. Spitzauer, and D. Kerjaschki. 1996. Lipoproteins accumulate in immune deposits and are modified by lipid peroxidation in passive Heymann nephritis. Am. J. Pathol. 149:1313-1320.
12. Neale, T.J., P.P. Ojha, M. Exner, H. Poczewski, B. Ruger, J.L. Witztum, P. Davis, and D. Kerjaschki. 1994. Proteinuria in passive Heymann nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. J. Clin. Invest. 94:1577-1584.
13. Orlando, R.A., and M.G. Farquhar. 1993. Identification of a cell line that expresses a cell surface and a soluble form of the gp330/receptor-associated protein (RAP) Heymann nephritis antigenic complex. Proc. Natl. Acad. Sci. USA. 90:4082-4086.
14. Saito, A., H. Yamazaki, K. Rader, A. Nakatani, R. Ullrich, D. Kerjaschki, R.A. Orlando, and M.G. Farquhar. 1996. Mapping rat megalin: the second cluster of ligand binding repeats contains a 46-amino acid pathogenic epitope involved in the formation of immune deposits in Heymann nephritis. Proc. Natl. Acad. Sci. USA. 93:8601-8605.
15. Kerjaschki, D., and M.G. Farquhar. 1982. The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc. Natl. Acad. Sci. USA. 79:5557-5581.
16. Miettinen, A., G. Dekan, and M.G. Farquhar. 1990. Monoclonal antibodies against membrane proteins of the rat glomerulus. Immunochemical specificity and immunofluorescence distribution of the antigens. Am. J. Pathol. 137:929-944.
17. Orlando, R.A., D. Kerjaschki, H. Kurihara, D. Biemesderfer, and M.G. Farquhar. 1992. gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc. Natl. Acad. Sci. USA. 89: 6698-6702.
18. Kerjaschki, D., and M.G. Farquhar. 1983. Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J. Exp. Med. 157:667-686.
19. Orlando, R.A., D. Kerjaschki, and M.G. Farquhar. 1995. Megalin (gp330) possesses antigenic epitopes capable of inducing passive Heymann nephritis independent of the nephritogenic epitope in RAP. J. Am. Soc. Nephrol. 6:61-67.
20. Armbruster, B.L., E. Carlemalm, R. Chiovetti, R.M. Gravioti, J.A. Hobot, E. Kellenberger, and W. Vilinger. 1982. Specimen preparation for electron microscopy using low temperature embedding resin. J. Microsc. (Oxf.). 126:77-92.
21. Horvat, R., A. Hovorka, G. Dekan, H. Poczewski, and D. Kerjaschki. 1986. Endothelial cell membranes contain podocalyxin - the major sialoprotein of visceral glomerular epithelial cells. J. Cell Biol. 102:484-491.
22. Lundstrom, M., R.A. Orlando, M.S. Saedi, L. Woodward, H. Kurihara, and M.G. Farquhar. 1993. Immunocytochemical and biochemical characterization of the Heymann nephritis antigenic complex in rat L2 yolk sac cells. Am. J. Pathol. 143:1423-1435.
23. Susani, M., M. Schulze, M. Exner, and D. Kerjaschki. 1994. Antibodies to glycolipids activate complement and promote proteinuria in passive Heymann nephritis. Am. J. Pathol. 144:807-819.
24. Kerjaschki, D., A. Miettinen, and M.G. Farquhar. 1987. Initial events in the formation of immune deposits in passive Heymann nephritis. gp330-anti-gp330 immune complexes form in epithelial coated pits and rapidly become attached to the glomerular basement membrane. J. Exp. Med 166:109-128.
25. Farquhar, M.G., A. Saito, D. Kerjaschki, and R.A. Orlando. 1995. The Heymann nephritis antigenic complex: megalin (gp330) and RAP. J. Am. Soc. Nephrol. 6:35-47.
26. Orlando, R.A., and M.G. Farquhar. 1994. Functional domains of the receptor-associated protein (RAP). Proc. Natl. Acad. Sci. USA. 91:3161-3165.
27. Czekay, R.P., R.A. Orlando, L. Woodward, M. Lundstrom, and M.G. Farquhar. 1997. Endocytic trafficking of megalin/RAP complexes: dissociation of the complexes in late endosomes. Mol. Biol. Cell. 8:517-532.
28. Couser, W.G. 1985. Mechanisms of glomerular injury in immune-complex disease. Kidney Int. 28:569-583.
29. Kerjaschki, D., M. Schulze, S. Binder, R. Kain, P. Ojha, M. Susani, R. Horvat, P.J. Baker, and W.G. Couser. 1989. Transcellular transport and membrane insertion of the C5b-9 membrane attack complex of complement by glomerular epithelial cells in experimental membranous nephropathy. J. Immunol. 143:546-552.
30. Shah, S.V. 1989. Role of reactive oxygen metabolites in experimental glomerular disease. Kidney Int. 36:1093-1106.
31. Witztum, J.L. 1994. The oxidation hypothesis of atherosclerosis. Lancet. 344:793-795.
32. Raychowdhury, R., G. Zheng, D. Brown, and R.T. McCluskey. 1996. Induction of Heymann nephritis with a gp330/megalin fusion protein. Am. J. Pathol. 148:1613-1623.
33. Orlando, R.A., M. Exner, R.P. Czekay, H. Yamazaki, A. Saito, R. Ullrich, D. Kerjaschki, and M.G. Farquhar. 1997. Identification of the second cluster of ligand binding repeats in megalin as a site for receptor-ligand interactions. Proc. Natl. Acad. Sci. USA. 94:2368-2373.
34. Edgington, T.S., R.J. Glassock, and F.J. Dixon. 1968. Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science (Wash. DC). 155:1432-1434.
35. Miettinen, A., T. Tornroth, I. Tikkanen, I. Virtanen, and E. Linder. 1980. Heymann nephritis induced by kidney brush border glycoproteins. Lab. Invest. 43:547-555.
36. Tsai, W.M., G. Roos, T.E. Hugli, and E.M. Tan. 1992. Influence of free thiol group(s) on autoantibody-defined epitope of proliferating cell nuclear antigen. J. Immunol. 149:2227-2233.
37. Sato, H., S. Suzuki, H. Kobayashi, S. Ogino, A. Inomata, and M. Arkawa. 1991. Immunohistological localization of apolipoproteins in the glomeruli in renal disease: specifically apo B and apo E. Clin. Nephrol. 36:127-133.