Infections in the elderly

Indian Journal of Medical Research

Volumn 106, Issue OCT., 1997, Pages 273-285

  Dey, A B ^a   Chaudhury, D ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Ageing; Immunity; Influenza; Pneumonia; Septicaemia; Tuberculosis; Urinary tract infection; Vaccine

Indexed keywords

AMINOGLYCOSIDE; AMINOPENICILLIN; ANTIBIOTIC AGENT; CEPHALOSPORIN DERIVATIVE; INFLUENZA VACCINE; PNEUMOCOCCUS VACCINE;

AGED; AGING; ANTIBIOTIC THERAPY; CELLULAR IMMUNITY; CLINICAL FEATURE; DISEASE PREDISPOSITION; DRUG SAFETY; ENDOCARDITIS; HUMAN; HUMORAL IMMUNITY; IMMUNE SYSTEM; INFECTION; MORPHOLOGY; MORTALITY; RESPIRATORY TRACT INFECTION; REVIEW; SEPTICEMIA; TUBERCULOSIS; URINARY TRACT INFECTION; VACCINATION;

AGED; AGING; BACTERIAL INFECTIONS; HUMANS; INDIA; VIRUS DISEASES;

EID: 0030685736     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (112)

1. Saltzman RL, Peterson PK. Immunodeficiency of the elderly. Rev Infect Dis 1987; 9: 1127-39.
2. Ben-Yehuda A, Weksler ME. Host resistance and the immune system. Clin Geriatr Med 1992;8:701-11.
3. Irvine PW, Van Buren N, Crossley K. Causes for hospitalisation of nursing home residents: The role of infection. J Am Ger Soc 1984; 32: 103-7.
4. Munoz E, Rosner F, Chalfin D, Goldstein J, Margolis IB, Wise L. Financial risk and hospital cost for elderly patients. Age and non-age related stratified medical diagnosis and related groups. Arch Intern Med 1988; 148: 909-12.
5. Gardner ID. The effect of ageing on susceptibility to infection. Rev Infect Dis 1980; 2:801-10.
6. Gardner ID, Remington JS. Ageing and the immune response. I. Antibody formation in Toxoplasma gondi-infected mice. J Immunol 1978; 120:939-43.
7. Gardner ID, Remington JS. Ageing and the immune response. II. Lymphocyte responsiveness and macrophage activation in Toxoplasma gondi-infected mice. J Immunol 1978; 120:944- 9.
8. Mufasko DM, Goonewardene IM. T cell function in ageing: mechanisms of decline. Annu Rev Gerontol Geriatr 1990; 10: 71-96.
9. Thoman ML, Weigle WO. The cellular and sub-cellular bases of immunosenescence. Adv Immunol 1989; 46:221-61.
10. Makinodan T, Bloom ET, James SJ, Lubinski J. Immunity and Ageing. In: Pathy MSJ, editor Principles and practice of geriatric medicine. 2nd edition. Chichester : John Wiley & Sons 1991: 3-13.
11. Marrie TJ. Epidemiology of community acquired pneumonia in the elderly. Semin Respir Infect 1990;5: 260-8.
12. Davies BH. The Respiratory System. In: Pathy MSJ, editor Principles and practice of geriatric medicine. 2nd edition Chichester : John Wiley & Sons 1991: 663-82.
13. Sood R, Dey AB, Kumar V. Clinical profile of febrile illnesses in elderly hospitalised patients. Indian Practioner 1990; 43:881-6 .
14. May DS, Kelly JJ, Mendlein JM, Garlec PL. Surveillance of major cause of hospitalisation among elderly, 1988, MMWR 1991; 40: 7-21.
15. Kumar V, Nagarkar K. Clinical profile of hospitalised elderly patients with chronic obstructive pulmonary disease. XVth International Congress of Gerontology, Budapest, Hungary (Abstract) 1993: 159.
16. Farr BM, Sloman AJ, Fisch MJ. Predicting death in patients hospitalized for community acquired pneumonia. Ann Intern Med 1991; 115:428-36.
17. Ebrighi JR, Rytel MW. Bacterial pneumonia in the elderly. J Am Geriatr Soc 1980; 28: 220-3.
18. Straczewski AR, Allen SC, Vargas E, Lye M. Clinical prognostic indices of fatality in elderly patients admitted to hospital with acute pneumonia. Age Ageing 1988, 17: 181-6.
19. Dey AB, Nagarkar KM, Kumar V. Clinical presentation and predictors of outcome in adult patients with community acquired pneumonia. Natl Med J Indian 1997; 10: 169-72.
20. Haley RW, Schaberg DR, Crossley KB, Von Allmen SD, McGowan JE Jr. Extra charges and prolongation of stay attributable to nosocomial infections. A prospective inter hospital comparison. Am J Med 1981; 70: 51-8.
21. Crossley KB, Thurn JR. Nursing home - acquired pneumonia. Semin Respir Inject 1989, 4:64-72.
22. Lu WX, Lo WC, Zhu YJ. Evaluation of the causative bacteria of pneumonia in the elderly in recent years. Chung Hua Nei Ko Tsa Chih 1989; 28:482-5.
23. Venkatesan P, Gladman J, Macfarlane JT, Barer D, Berman P, Kinnear W et al. A hospital study of community acquired pneumonia in the elderly. Thorax 1990; 45: 254-8.
24. The British Thoracic Society and the Public Health Laboratory Service. Community acquired pneumonia in adults British hospitals in 1982-1983 : a survey of aetiology, mortality and prognostic factors and outcome. Q J Med 1987; 62: 195-220.
25. Winter JH. The scope of lower respiratory tract infection. Infection 1991; 19 Suppl-7: S359-64.
26. Bentley DW. Bacterial pneumonia in the elderly : Clinical features, diagnosis, etiology and treatment. Gerontology 1984; 30: 297-307.
27. Kayser FH. Changes in the spectrum of organisms causing respiratory tract infections : a review. Postgrad Med J 1992; 68 Suppl. 3: S17-S23.
28. Isenberg HD, Washington JA, Doern GV, Amsterdam D. Specimen collection and handling. In: Washington DC, Balows A, Hausler WJ, Herman KL, Isenberg HD, Shadomy HJ. editors Manual of clinical microbiology 5th edition. American Society of Microbiology, 1991:15.
29. Barrett-Connor E. The non value of sputum culture in the diagnosis of pneumococcal pneumonia. Am Rev Resp Dis 1971;103:845-8.
30. Wallace RJ, Musher DM, Martin RR. Hemophilus influenzae pneumonia in adults. Am J Med 1978; 64:87-93.
31. Davidson M, Tempest B, Palmer DL. Bacteriological diagnosis of acute pneumonia. Comparison of sputum, transtracheal aspirates and lung aspirates. JAMA 1976;235:158-63.
32. Hoeprich PD. Etiologic diagnosis of lower respiratory tract infections. Calif Med 1970; 112: 1-8.
33. Kahn FW, Jones JM. Diagnosing bacterial infection by bronchoalveolar lavage. J Infect Dis 1987; 155: 862-9.
34. Sharma BK, Manjunatha S, Verma S, Singh S, Sagar S. Profile of pneumonias in hospitalised medical patients. Indian J Chest Dis Allied Sci 1988;30:199-204.
35. Kulpati DD, Kumar A. Flexible fiberoptic bronchoscopy in lower respiratory tract infection. Indian J Chest Allied Sci 1980;22:39-46.
36. Madhu SV, Gupta U, Guleria JS, Talwar V. Clinical and bacteriological profile of hospitalized community acquired pneumonias-A preliminary study. Indian J Chest Dis Allied Sci 1990;32:95-100.
37. Mandell LA, Niederman MS. The Canadian Community Acquired Pneumonia Consensus Group. Antimicrobial treatment of community acquired pneumonia in adults: a conference report. Can J Infect Dis 1993; 4:25-8.
38. American Thoracic Society. Guidelines for the initial management of adults with community acquired pneumonia: diagnosis, assessment of severity and initial antimicrobial therapy. Am Rev Resp Dis 1993; 148:1418-26.
39. Fine MJ, Smith DN, Singer DE. Hospitalization decision in patients with community acquired pneumonia: a prospective cohort study. Am J Med 1990; 89: 713-21.
40. McGehee JL, Podnos SD, Pierce AK, Weissler JC. Treatment of pneumonia in patients at risk of infection with Gram negative organisms. Ann Int Med 1988;84:597-602.
41. Khan FA, Basir R. Sequential intravenous-oral administration of ciprofloxacin vs. ceftazidime in serious bacterial respiratory tract infection. Chest 1989; 96: 453-6.
42. Rosen H. Renal disease in elderly. Med Clin North Am 1976; 60: 1105-19.
43. Cox JR, Macias-Nunez JF, Dowd AB. Renal disease. In: Pathy MSJ. editor Principles and practice of geriatric medicine. 2nd edition. Chichester : John Wiley & Sons. 1991: 1159-77.
44. Sourander LB. Urinary tract infection in the aged. Ann Med Inter Fenn 1966; 45:55-62.
45. Mou TW, Siroty R, Ventry P. Bacteriuria in elderly chronically ill patients. J Am Geriatr Soc 1962; 10: 170-8.
46. Wolfson S. Epidemiology of bacteriuria in predominantly geriatric male population. Am J Med Sci 1965; 250: 168-73.
47. Baldassarre JS, Kaye D. Special problems of urinary tract infection in the elderly. Med Clin North Am 1991;75:375-90.
48. Nicolle LE, Bjornson J, Harding GK, MacDonnel JA. Bacteriuria in elderly institutionalized men. N Engl J Med 1983;309:1420-5.
49. Nicolle LE, Mayhew WJ, Bryan L. Prospective randomised comparison of therapy and no therapy for asymtomatic bacteriuria in institutionalized elderly women. Am J Med 1987; 83:27-33.
50. Dontas AS, Papanyiotou P, Marketos SG, Papanicolaou N, Economiou P. The effect of bacteriuria on renal functional patterns in old age. Clin Sci 1966; 34: 73-81.
51. Maill WL, Kass EH, Ling J, Stuart KL. Factors influencing arterial pressure in general population in Jamaica. Br Med J 1962; 1: 497-506.
52. Harbord RB, Gruneburg RN. Treatment of urinary tract infection with single dose of amoxycillin, co-trimoxazole or trimethoprim. Br Med J 1981; 283: 1301-2.
53. Sabanathan K, Castleden CM, Mitchell CJ. The problem of bacteriuria with indwelling urethral catheterisation. Age Ageing 1985; 14: 85-90.
54. FitzGerald JM, Grzybowski S, Allen EA. The impact of human immunodeficiency virus infection on tuberculosis and its control. Chest 1991; 100: 191-200.
55. Korzenicwska-Kosela M, FitzGerald JM, Vedal S, Allen EA, Schecter MT, Lawson L etal. Spectrum of tuberculosis in patients with HIV infection in British Columbia: report of 40 cases. Can Med Assoc J 1992; 146: 1927-34.
56. Prabhakar R. Tuberculosis- the continuing scourge of India. Indian J Med Res 1996; 103: 19-25.
57. Nisar M, Davies PD. Current trends in tuberculosis mortality in England and Wales. Thorax 1991; 46: 438-40.
58. Stead WW, Lofgren JP. Does the risk of tuberculosis increase in old age? J. Infect Dis 1983; 147: 951-5.
59. General Register Officer. Studies on medical and population subjects. No. 10. Tuberculosis statistics for England and Wales 1938-1955. London HMSO, 1955.
60. Frost WH. The age selection of mortality from tuberculosis in successive decades. Am J Hyg 1939; 30: 91-6.
61. Grzybowski S, Mar WB. The unchanging pattern of pulmonary tuberculosis. Can Med Assoc J 1963; 89:737-40.
62. Davidson PT. Tuberculosis : new views of an old disease. N Engl J Med 1985; 312: 1514-15.
63. Stead WW, Lofgren JP, Warren E, Thomas C. Tuberculosis as an endemic and nosocomial infection among the elderly in nursing homes. N Engl J Med 1985; 312:1483-7.
64. Macarthur C, Enarson DA, Fanning EA, Hessel PA, Newman S. Tuberculosis among institutionalized elderly in Alberta, Canada. Int J Epidemiol 1992; 21: 1175-9.
65. Korzeniewska-Kosela M, Krysl J, Muller N, Black W, Allen E, FitzGerald JM. Tuberculosis in young adults and the elderly -A prospective comparison study. Chest 1994; 106: 28-32.
66. Chan CHS, Woo J, Or KKH, Chan RCY, Cheung W. The effect of age on the presentation of patients with tuberculosis. Tubercle Lung Dis 1995; 76: 290-4.
67. Morris CDW. The radiology, haematology and blood chemistry of pulmonary tuberculosis in the aged. Q J Med 1989; 71: 529-36.
68. Mackay AD, Cole RB. The problem of tuberculosis in the elderly. Q J Med, 1984; 53: 497-510.
69. Arora VK, Bedi RS. Geriatric tuberculosis in Himachal Pradesh: a clinico-radiological profile. J Assoc Physicians India 1989; 37: 205-7.
70. Gambhir IS, Mishra V, Singh DS. Tuberculosis in elderly. National Conference on Gerontology, Gwalior (Abstract). 1997: 50-1.
71. Harries A, Maher D. Treatment of TB patients. In: TB- A clinical manual for south-east Asia. Geneva : World Health Organisation 1997; 57-67.
72. Treatment of tuberculosis-Guidelines for national programmes Geneva. World Health Organ 1993: 36-8.
73. Stead WW, To T, Harrison RW, Abraham JH, 3rd. Benefit - risk considerations in preventive treatment for tuberculosis in elderly persons. Ann Intern Med 1987; 107: 843-5.
74. Gronhagen Riska C, Hellstrom PE, Forseth B. Predisposing factors in hepatitis induced by isoniazid rifampicin treatment of tuberculosis. Am Rev Resp Dis 1978; 118: 461-6.
75. Lees AW, Asgher B, Hashem MA, Sinha BN. Jaundice after rifampicin. Br J Dis Chest 1970; 64: 90-5.
76. van den Brande P, van Streenbergen W, Vervoort G, Demedts M. Ageing and hepatotoxicity of isoniazid and rifampicin in pulmonary tuberculosis. Am J Resp Crit Care Med 1995; 152: 1705-8.
77. Yoshikawa TT. Tuberculosis in ageing adults. J Am Geriatr Soc 1992; 40: 178-87.
78. Cantrell M, Yoshikawa TT. Ageing and infective endocarditis. J Am Geriatr Soc 1983; 31: 216-22.
79. Terpenning MS, Buggy BP, Kauffman CA. Infective endocarditis: clinical features in young and elderly patients. Am J Med 1987; 83: 626-34.
80. Watanakunakorn C, Burkert T. Infective endocarditis at a large community teaching hospital, 1980-1990. A review of 210 episodes. Medicine (Baltimore) 1993; 72: 90-102.
81. Dajani AS, Bisno AL, Chung KJ, Durack DT, Freed M, Gerber MA et al. Prevention of bacterial endocarditis. Recommendations by the American Heart Association. JAMA 1990; 264: 2919-22.
82. Brandeis GH, Morris JN, Nash DJ, Lipsitz LA. The epidemiology and natural history of pressure ulcers in elderly nursing home residents. JAMA 1990; 264: 2905-9.
83. Kertesz D, Chow AW. Infected pressure and diabetic ulcers. Clin Geriatr Med. 1992; 8: 835-52.
84. Smith DM, Winsemius DK, Besdine RW. Pressure sores in the elderly : Can its outcome be improved? J Gen Intern Med 1991; 6: 81-93.
85. Auerbach SB, Schwartz B, Williams D, Fiorilli MG, Adimora AA, Breiman RF. et al. Outbreak of invasive group A streptococcal infections in a nursing home. Lessons on prevention and control. Arch Intern Med 1992; 152: 1017-22.
86. Mc Guire NM, Kauffman CA. Septic arthritis in the elderly. J Am Geriatr Soc 1985; 33: 170-4.
87. Norman DC, Yoshikawa TT. Responding to septic arthritis. Geriatrics 1983; 38: 83-91.
88. Lew JF, Glass RI, Gangarosa RE, Cohen IP, Bern C, Moe CL. Diarrhoeal deaths in the United States, 1979 through 1987. A special problem for the elderly. JAMA 1991; 265: 3280-4.
89. Gellert GA, Waterman SH, Ewert D, Oshiro L, Giles MP, Monroe SS et al. An outbreak of acute gastroenteritis caused by a small round structured virus in a geriatric convalescent facility. Infect Control Hasp Epidemiol 1990; 11: 459-64.
90. Bentley DW. Clostridium difficile-associated disease in long term care facility. Infect Control Hasp Epidemiol 1990; 11: 434-8.
91. Ryan CA, Tauxe RV, Hosek GW, Wells JG, Stoesz PA, McFadden HW, Jr et al. Escherichia coli 0157: H7 diarrhea in a nursing home: Clinical, epidemiological and pathological findings. J Infect Dis 1986; 154: 631-8.
92. McCue JD. Gram negative bacillary bacterimia in the elderly: incidence, eciology and mortality. J Am Geriatr Soc 1987; 35: 213-8.
93. Holloway WJ. Management of sepsis in the elderly. Am J Med 1986; 80 Suppl (6B): 143-8.
94. Hodgin UG, Sanford JP. Gram negative rod bacteremia. An analysis of 100 patients. Am J Med 1965;39:952-60.
95. Uzun O, Akalin HE, Hayran M, Unal S. Factors influencing prognosis in bacteremia due to Gram negative organisms: evaluation of 448 episodes in a Turkish university hospital. Clin Infect Dis 1992; 15: 866-73.
96. Meyers BR, Sherman E, Mendelson MH, Velasquez G, Srulevitch-Chin E, Hubbard M et al. Blood stream infections in the elderly. Am J Med 1989; 86: 379-84.
97. Richardson JP. Bacteremia in the elderly. J Gen Intern Med 1993;8:89-92.
98. Setia U, Serventi I, Lorenz P. Bacteremia in long term care facility. Spectrum and mortality. Arch Intern Med 1984; 144:1633-5.
99. Gleckman R, Hibert D. A febrile bacteremia: A phenomenon in geriatric patients. JAMA 1982; 248: 1478-81.
100. Norman DC, Yoshikawa TT. Recognising bacterial meningitis in the elderly. Geriatr Med Today 1984; 3:85-8.
101. Aronson SM, DeBuono BA, Buechner JS. Acute bacterial meningitis in Rhode Island: A survey of the years 1976 to 1985. Rhode Island Med J 1991; 74: 33.
102. Gorse GJ, Thrupp LD, Nudleman KL, Wyle FA, Hawkins B, Cesario TC. Bacterial meningitis in elderly. Arch Intern Med 1984; 144: 1603-7.
103. Behrman RE, Meyers BR, Mendelson MH, Sacks HS, Hirschman SZ. Central nervous system infections in the elderly. Arch Intern Med 1989; 149: 1596-9.
104. Looser JD. Herpes zoster and post-herpetic neuralgia. Pain 1986; 25:149-64.
105. Watson PN, Evans RJ. Post-herpetic neuralgia: a review. Arch Neurol. 1986;43:836-40.
106. Fox RH, McGibbon R, Davies L, Woodward PM. Problem of the old and the cold. Br Med J 1973;1:21-4.
107. Esposito AL, Gleckman RA. Fever of unknown origin in the elderly. J Am Geriatr Soc 1978;26:498-505.
108. Yoshikawa TT, Norman DC. Ageing and infectious disease. In: Pathy MSJ editor. Principle and practice of geriatric medicine. 2nd edition. Chichester. John Wiley & Sons 1991: 313-8.
109. Fine MJ, Smith MA, Carson CA, Meffe F, Sankey SS, Weissfield LA et al. Efficacy of pneumococcal vaccine in adults : a meta-analysis of randomised controlled trials. Arch Intern Med 1994; 154: 2666-77.
110. Salisburg DM, Begg NT. editor Immunisation against infectious disease. London HMSO. 1996; 113-20; 167-72.
111. Ahmed A'EH, Nicholson KG, Nguyen-Van-Tam JS. Reduction in mortality associated with influenza vaccine during 1989-90 epidemic. Lancet 1995; 346: 591-5.
112. Sheffield FW. To give or not to give; guidelines for tetanus vaccine. Community View 1985;33:8-9.