Immunohistochemical expression of nm23 gene product, nucleotide diphosphate kinase, in pancreatic neoplasms

International Journal of Pancreatology

Volumn 22, Issue 1, 1997, Pages 59-66

  Ohshio, Gakuji ^a   Imamura, Takashi ^a   Okada, Noriyuki ^a   Suwa, Hirofumi ^a   Yamaki, Kenichirou ^a   Imamura, Masayuki ^a   Ogasahara, Keizo ^b   Tsukayama, Choutatsu ^c   Yamabe, Hirohiko ^d  

^a KYOTO UNIVERSITY   (Japan)

^b Kurashiki Chuou Hospital   (Japan)

^c Department of Pathology   (Japan)

^d KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Abnormal wing disk (awd) gene; Ampullary carcinoma; Islet cell tumor; Nm23; Nucleoside diphosphate (NDP) kinase; Pancreatic carcinoma

Indexed keywords

GENE PRODUCT; NUCLEOTIDE; PHOSPHOTRANSFERASE; PYROPHOSPHATE;

ADULT; AGED; ARTICLE; CANCER INHIBITION; CANCER LOCALIZATION; CLINICAL ARTICLE; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MALE; PANCREAS CARCINOMA; PRIORITY JOURNAL;

EID: 0030684697     PISSN: 01694197     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02803906     Document Type: Article

References (26)

1. Steeg P, Bevilacqua G, Kopper L, Thorgeirsson UP, Talmadge JE, Liotta LA, Sobel ME. Evidence for a novel gene associated with low tumor metastatic potential. J Natl Cancer Inst 1988; 80: 200-204.
2. Rosengard AM, Krutzsch HC, Shearn A, Biggs JR, Barker EB, Margulies IMK, King CR, Liotta LA, Steeg PS. Reduced nm23/awd protein in tumour metastasis and aberrant Drosophilia development. Nature 1989; 342: 177-180.
3. Bevilacqua G, Sobel ME, Liotta LA, Steeg PS. Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential. Cancer Res 1989; 49: 5185-5190.
4. Hennessy C, Henry JA, May FEB, Westley BR, Angus B, Lennard TWJ. Expression of the antimetastatic gene nm23 in human breast cancer: an association with good prognosis. J Natl Cancer Inst 1991; 83: 281-285.
5. Barnes R, Masood S, Barker E, Rosengard AM, Coggin DL, Crowell T, King CR, Jordan KP, Wargotz ES, Liotta LA, Steeg PS. Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival. Am J Pathol 1991; 139: 245-250.
6. Leone A, Flatow U, King CR, Sandeen MA, Marguilies CR, Liotta LA, Steeg PA. Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells. Cell 1991; 65: 25-35.
7. Haut M, Steeg PS, Willson JK, Markowitz SD. Induction of nm23 gene expression in human colonic neoplasms and equal expression in colon tumors of high and low metastatic potential. J Natl Cancer Inst 1991; 83: 712-716.
8. Nakamori S, Ishikawa O, Ohhigashi H, Kameyama M, Furukawa I-I, Sasaki Y, Inaji H, Higashiyama M, Imaoka S, Iwanaga T, Funai H, Wada A, Kimura N. Expression of nucleoside diphosphate kinase/nm23 gene product in human pancreatic cancer: an association with lymph node metastasis and tumor invasion. Clin Exp Metastasis 1993; 11: 151-158.
9. Nakamori S, Ishikawa O, Ohigashi H, Imaoka S, Sasaki Y, Kameyama M, Kabuto T, Furukawa H, Iwanaga T, Kimura N. Clinicopathological features and prognostic significance of nucleoside diphosphate kinase/nm23 gene product in human pancreatic exocrine neoplasms. Int J Pancreatol 1993; 14: 125-134.
10. Gibson JB. Histological typing of tumours of the liver, biliary tract and pancreas. International histological classification of tumours. World Health Organization, 1978.
11. Klöppel G, Lingenthal G, Vonbulow M, Kern HF. Histological and fine structural features of pancreatic ductal adenocarcinomas in relation to growth and prognosis: studies in xenografted tumours and clinico-histopathological correlation in a series of 75 cases. Histopathology 1985; 9: 841-856.
12. Ohshio G, Yoshioka H, Manabe T, Sakahara H, Yamahe H, Imamura M, Inoue M, Tanaha N, Nakada H, Yanmashina I. Expression of sialosyl-Tn antigen (monoclonal antibody MLS102 reactive) in normal tissues and malignant tumors of the digestive tract. J Cancer Res Clin Oncol 1994; 29: 325-330.
13. Biggs J, Hersperger E, Steeg PS, Liotta LA, Sheani A. A Drosophilia gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase. Cell 1990; 30: 933-940.
14. Randazzo PA, Northup JK, Kahn RA. Activation of a small GTP-binding protein by nucleoside diphosphate kinase. Science 1991; 254: 850-853.
15. Teng DHF, Engele CM, Venkatesh RV. A product of the pure locus of Drosophilia is similar to mammalian GTPase-activating protein. Nature 1991; 353: 437-440.
16. Liotta LA, Steeg PS. Clues to the function of nm23 and awd proteins in development, signal transduction, and tumor metastasis provided by studies of dicytostelium discoideum. J Natl Cancer Inst 1990; 82: 1170-1172.
17. Hirayama R, Sawai S, Tahagi Y, Mishima Y, Kimura N, Shimada N, Esaki Y, Kurashima C, Utsuyama M, Hirokawa K. Positive relationship between expression of antimetastatic factor (nm23 gene product or nucleoside diphosphate kinase) and good prognosis in human breast cancer. J Natl Cancer Inst 1991; 17: 1243-1251.
18. Konishi N, Nakaoka S, Tsuzuki T, Matsumoto K, Kitahori Y, Hiasa Y, Urano T, Shiku H. Expression of nm23-H1 and nm23-H2 proteins in prostate carcinoma. Jpn J Cancer Res 1993; 84: 1050-1054.
19. Kodera Y, Isobe K, Yamauchi M, Kondoh K, Kimura N, Pharm D, Akiyama S, Itoh K, Nakashima I, Takagi H. Expression of nm23 H-1 RNA levels in human gastric cancer tissues. A negative correlation with nodal metastasis. Cancer 1994; 73: 259-265.
20. Higashiyama M, Doi O, Yokouchi H, Kodama K, Nakamori S, Tateishi R, Kimura N. Immunohistochemical analysis of nm23 gene product NDP kinase expression in pulmonary adenocarcinoma: lack of prognostic value. Br J Cancer 1992; 66: 533-536.
21. Sastre-Garau X, Lacombe ML, Jouve M, Magdelenat H. Nucleoside diphosphate kinase/nm23 expression in breast cancer: lack of correlation with lymph-node metastasis. Int J Cancer 1992; 50: 533-538.
22. Lacombe ML, Sastre-Garau X, Lascu I, Vonica AV, Wallet V, Thiery JP, Veron M Overexpression of nucleoside diphosphate kinase (nm23) in solid tumours. Eur J Cancer 1991; 27; 1302-1307.
23. Hailat N, Keim DR, Melhem RF, Zhu XX, Eckerskorn C, Brodeur GM, Reynolds CP, Seeger RC, Lottspeich F, Strahler JR, Hanash SM. High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification. J Clin Invest 1991; 88: 341-345.
24. Stahl JA, Leone A, Rosengard AM, Porter L, King CR, Steeg PS. Identification of a second human nm23 gene. nm23-H2. Cancer Res 1991; 51: 445-449.
25. Gilles AM, Presecan E, Vonica A, Lascu I. Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneneity of the hexameric enzyme. J Biol Chem 1991; 266: 8784-8789.
26. Keim D, Hailat N, Melhem R, Zhu XX, Lascu I, Veron M, Strahler J. Proliferation-related expression of 19/nm23 nucleoside diphosphate kinase. J Clin Invest 1992; 89: 919-924.