Poecillanosine, a new free radical scavenger from the marine sponge Poecillastra spec. aff. tenuilaminaris

Tetrahedron Letters

Volumn 38, Issue 48, 1997, Pages 8349-8350

  Natori, Takenori ^a   Kataoka, Yoko ^a   Kato, Shinichiro ^a   Kawai, Hiroyuki ^a   Fusetani, Nobuhiro ^b  

^a KIRIN BREWERY CO LTD   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

NITROSOHYDROXYALKYLAMINE; POECILLANOSINE; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOASSAY; CHEMICAL STRUCTURE; ISOLATION PROCEDURE; LIPID PEROXIDATION; MARINE ENVIRONMENT; MOUSE; NONHUMAN; RAT; SIGNAL TRANSDUCTION; SPONGE (PORIFERA); STRUCTURE ANALYSIS;

ANIMALIA; POECILLASTRA; PORIFERA;

EID: 0030683598     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10260-X     Document Type: Article

References (11)

1. Stadtman, E. R. Science 1992, 257, 1220-1224; Cadenas, E. Annu. Rev. Biochem. 1989, 58, 79-110.
2. Stadtman, E. R. Science 1992, 257, 1220-1224; Cadenas, E. Annu. Rev. Biochem. 1989, 58, 79-110.
3. Kalo, S.; Kawai, H.; Kawasaki, T.; Toda, Y.; Urata, T.; Hayakawa, Y. J. Antibiot. 1989, 42, 1879-1881.
4. Sponge samples were collected at a depth of 25 m off the Sada Peninsula, immediately frozen, and transported frozen to our laboratory. The sponge was identified as Poecillastra spec. aff. tenuilaminaris Sollas, 1888 by Dr. Rob W. M. van Soest, and a voucher specimen (ZMA POR. 10121) was deposited at Zoological Museum of the University of Amsterdam.
5. 3) δ 14.3, 20.8, 22.8, 25.1, 29.7, 32.0, 61.7, 70.6, 171.5.
6. Carmack, M.; Leavitt, J. J. J. Am. Chem. Soc. 1949, 71, 1221-1223.
7. Coronelli, C.; Pasqualucci, C. R.; Tamoni, G.; Gallo, G. G. Farmaco Ed. Sci. 1966, 21, 269-277.
8. Abe, Y.; Kadokura, J.; Shimazu, A.; Seto, H.; Ohtake, N. Agric. Biol. Chem. 1983, 47, 2703-2705; Dolak, L. A.; Castle, T. M. J. Antibiot. 1983, 36, 916-917.
9. Abe, Y.; Kadokura, J.; Shimazu, A.; Seto, H.; Ohtake, N. Agric. Biol. Chem. 1983, 47, 2703-2705; Dolak, L. A.; Castle, T. M. J. Antibiot. 1983, 36, 916-917.
10. 3) δ 14.1 q (C17), 20.85 q (OAc), 22.7 t (C16), 24.9 t (C4), 29.2 t, 29.3 t, 29.4 t, 29.5 t, 29.58 t, 29.62 t (2C), 29.65 t (3C), 31.7 t (C3), 31.9 t (C15), 61.3 q (OMe), 65.4 t (C1), 70.0 d (C2), 170.0 s (OAc); negative FABMS (diethanolamine/glycerol) m/z 371, 357 (base peak), 342, 327, 253.
11. 23 -1.36° (c 0.27, benzene).