Protective immunity elicited by vaccination with DNA encoding for a B cell and a T cell epitope of the A/PR/8/34 influenza virus

Viral Immunology

Volumn 10, Issue 3, 1997, Pages 129-136

  Casares, Sofia ^a   Brumeanu, Teodor Doru ^a   Bot, Adrian ^a   Bona, Constantin A ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; EPITOPE; IMMUNOGLOBULIN; IMMUNOGLOBULIN HEAVY CHAIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; HUMORAL IMMUNITY; IMMUNOGLOBULIN VARIABLE REGION; INFLUENZA VACCINATION; INFLUENZA VIRUS; LETHAL DOSE; MOUSE; NONHUMAN; PLASMID; T LYMPHOCYTE; VACCINATION; VIRUS IMMUNITY;

ANIMALIA; INFLUENZA VIRUS;

EID: 0030682143     PISSN: 08828245     EISSN: None     Source Type: Journal    
DOI: 10.1089/vim.1997.10.129     Document Type: Article

References (12)

1. Brumeanu, T.D., A. Bot, C.A. Bona, P. Dehazya, I. Wolf, and H. Zaghouani. 1996. Engineering of doubly antigenized immunoglobulins expressing T and B viral epitopes. Immunotechnology 2:85-95.
2. Brumeanu, T.D, S. Casares, A. Bot, S. Bot, and C.A. Bona. 1997. Immunogenicity of a contiguous T-B synthetic epitope of the A/PR/8/34 influenza virus. J. Virol. 71:5473-5480.
3. Brumeanu, T.D., P. Dehazya, I. Wolf, and C.A. Bona. 1995. Enzymatically mediated, glycosidic conjugation of immunoglobulins with viral epitopes. J. Immunol. Methods 183:185-197.
4. Brumeanu, T.D., H. Zaghouani, R. Kohanski, and C.A. Bona. 1993. A sensitive method to detect defined peptide among those eluted from murine MHC class II molecules. J. Immunol. Methods 160:65-71.
5. Caton, A.J., G.C. Brownlee, J.W. Yewdell, and W.V. Gerhard. 1992. The antigenic structure of the influenza A/PR/8/34 hemagglutinin (H1 subtype). Cell 31:417-421.
6. Davis, H.L., R.G. Whalen, and B.A. Demeneix. 1993. Direct gene transfer into skeletal muscle in vivo: factors affecting efficiency of transfer and stability of expression. Human Gene Ther. 4:151-155.
7. Ertl, E.C.J., and Z.Q. Xiang. 1996. Genetic immunization. Viral Immunol. 9:1-9.
8. Haberman, A.M., C. Moller, D. McCreedy, and W.V. Gerhard. 1990. A large degree of functional diversity exists among helper T cells specific for the same antigenic site of influenza hemagglutinin. J. Immunol. 145:3087-3094.
9. Moran, T., Y.-N.C. Liu, J.L. Schulman, and C.A. Bona. 1984. Shared isiotopes among monoclonal antibodies specific for A/PR/8/34 (H1N1) and X-31 (H3N2) influenza viruses. Proc. Natl. Acad. Sci. USA 81:1809-1812.
10. Reale, M.A., C.A. Bona, and J.L. Schulman. 1985. Isotype profiles of anti-influenza antibodies in mice bearing the xid defect. J. Virol. 53:425-429.
11. Usuba, O., J.L. Schulman, M.A. Dealty, C.A. Bona, and T. Moran. 1990. New method for titration of virus infectivity by immunostaining. Viral Immunol. 3:237-241.
12. Wolf, J.A., R.W. Malone, P. Williams, W. Wong, G. Acsadi, A. Jani, and P.L. Feigner. 1990. Direct gene transfer into mouse muscle in vivo. Science 247:1465-1468.