Distribution of N-methyl-D-aspartate and non-N-methyl-D-aspartate glutamate receptor subunits on respiratory motor and premotor neurons in the rat

Journal of Comparative Neurology

Volumn 389, Issue 1, 1997, Pages 94-116

  Robinson, Deborah ^a   Ellenberger, Howard ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Cerebral cortex; Hippocampus; Medulla oblongata; Phrenic nucleus; Ventral respiratory group

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; RECEPTOR SUBUNIT;

ANIMAL TISSUE; ANTIBODY LABELING; ARTICLE; CELLULAR DISTRIBUTION; DATA ANALYSIS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; PREMOTOR CORTEX; PRIORITY JOURNAL; RAT; RESPIRATORY NERVE CELL;

ANIMALS; BRAIN; IMMUNOHISTOCHEMISTRY; MALE; MEDULLA OBLONGATA; MOTOR NEURONS; PERFUSION; PHRENIC NERVE; PROSENCEPHALON; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; SPINAL CORD;

EID: 0030680268     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19971208)389:1<94::AID-CNE7>3.0.CO;2-9     Document Type: Article

References (53)

1. Abrahams, T.P., P.J. Hornby, D.P. Walton, A.M. Taviera Da Silva, and R.A. Gillis (1991) An excitatory amino acid(s) in the ventrolateral medulla is (are) required for breathing to occur in the anesthetized cat. J. Pharmacol. Exp. Ther. 259:1388-1395.
2. Barnes, J.M., and J.M. Henley (1992) Molecular characteristics of excitatory amino acid receptors. Progr. Neurobiol. 39:113-133.
3. Böhmer, G., K. Schmid, and W. Schauer (1991) Evidence for an involvement of NMDA and non-NMDA receptors in synaptic excitation of phrenic motoneurons in the rabbit. Neurosci. Lett. 130:271-274.
4. Chitravanishi, V.C., and H.N. Sapru (1996) NMDA as well as non-NMDA receptors mediate the neurotransmission of inspiratory drive to phrenic motoneurons in the adult rat. Brain Res. 715:104-112.
5. Connelly, C.A., M.R. Otto-Smith, and J.L. Feldman (1992) Blockade of NMDA receptor-channels by MK-801 alters breathing in adult rats. Brain Res. 596:99-110.
6. Diemer, N.H., E. Valente, T. Bruhn, M. Berg, M.B. Jorgensen, and F.F. Johansen (1993) Glutamate receptor transmission and ischemic nerve cell damage: Evidence for involvement of excitotoxic mechanisms. Progr. Brain Res. 96:105-123.
7. Dobbins, E.G., and J.L. Feldman (1994) Brainstem network controlling descending drive to phrenic motoneurons in rat. J. Comp. Neurol. 347:64-86.
8. Ellenberger, H.H., and J.L. Feldman (1988) Monosynaptic transmission of respiratory drive to phrenic motoneurons from brainstem bulbospinal neurons in rats. J. Comp. Neurol. 269:47-57.
9. Ellenberger, H.H., and J.L. Feldman (1990) Subnuclear organization of the lateral tegmental field of the rat. I: Nucleus ambiguus and ventral respiratory group. J. Comp. Neurol. 294:202-211.
10. Ellenberger, H.H., and J.L. Feldman (1994) Origins of excitatory drive within the respiratory network: Anatomical localization. Neuroreport 5:1933-1936.
11. Ellenberger, H.H., J.L. Feldman, and W.Z. Zhan (1990a) Subnuclear organization of the lateral tegmental field of the rat. II: Catecholamine neurons and ventral respiratory group. J. Comp. Neurol. 294:212-222.
12. Ellenberger, H.H., P.L. Vera, J.R. Haselton, C.L. Haselton, and N. Schneiderman (1990b) Bulbospinal projections to the phrenic motor nucleus: A horseradish peroxidase study in the rabbit. Brain Res. Bull. 24:163-174.
13. Fedorko, L., and E.G. Merill (1984) Axonal projections from the rostral expiratory neurones of the Bötzinger complex to medulla and spinal cord in the cat. J. Physiol. (Lond) 350:487-496.
14. Fedorko, L., E.G. Merrill, and J. Lipski (1983) Two descending medullary inspiratory pathways to phrenic motoneurones. Neurosci. Lett. 43:285-291.
15. Feldman, J.L., and D.F. Speck (1983) Interactions among inspiratory neurons in dorsal and ventral respiratory groups in cat medulla. J. Neurophysiol. 49:472-490.
16. Funk, G.D., J.C. Smith, and J.L. Feldman (1993) Generation and transmission of respiratory oscillations in medullary slices: Role of excitatory amino acids. J. Neurophysiol. 70:1497-1515.
17. Funk, G.D., J.C. Smith, and J.L. Feldman (1995) Modulation of neural network activity in vitro by Cyclothiazide, a drug that blocks desensitization of AMPA receptors. J. Neurosci. 15: 4046-4056.
18. Furuyama, T. H. Kiyama, K. Sato, H.T. Park, H. Maeno, H. Takagi, and M. Tohyama (1993) Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Mol. Brain Res. 18: 141-151.
19. Good, P.F., G.W. Huntley, S.W. Rogers, S.F. Heinemann, and J.H. Morrison (1993) Organization and quantitative analysis of kainate receptor subunit GluR5-7 immunoreactivity in monkey hippocampus. Brain Res. 624:347-353.
20. Greer, J.J., J.C. Smith, and J.L. Feldman (1991) Role of excitatory amino acids in the generation and transmission of respiratory drive in neonatal rat. J. Physiol. (Lond) 437:727-749.
21. Hata, R., A. Matsumoto, T. Hatakeyama, T. Ohtsuki, N. Handa, M. Niinobe, K. Mikoshiba, S. Sakaki, T. Nishimura, and T. Yanagihara (1993) Differential vulnerability in the hindbrain neurons and local cerebral blood flow during bilateral vertebral occlusion in gerbils. Neuroscience 56:423-439.
22. Huntley, G.W., S.W. Rogers, T. Moran, W. Janssen, N. Archin, J.C. Vickers, K. Cauley, S.F. Heinemann, and J.H. Morrison (1993) Selective distribution of kainate receptor subunit immunoreactivity in monkey neocortex revealed by a monoclonal antibody that recognizes glutamate receptor subunits GluR5/6/7. J. Neurosci. 13:2965-2981.
23. Jonas, P., and N. Spruston (1994) Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the CNS. Curr. Opin. Neurobiol. 4:366-372.
24. Jones, K.A., and R.W. Baughman (1991) Both NMDA and non-NMDA subtypes of glutamate receptors are concentrated at synpases on cerebral cortical neurons in culture. Neuron 7:593-603.
25. Kashiwagi, M., H. Onimaru, and I. Homma (1993) Effects of NMDA on respiratory neurons in newborn rat medulla in vitro. Brain Res. Bull. 32:65-69.
26. Kawasaki, K., S.F. Traynelis, and R. Dingledine (1990) Different response of CA1 and CA3 regions to hypoxia in rat hippocampal slice. J. Neurophysiol. 63:385-394.
27. Kyrozis, A., P.A. Goldstein, M.J.S. Heath, and A.B. MacDermott (1995) Calcium entry through a subpopulation of AMPA receptors desensitized neighbouring NMDA receptors in rat dorsal horn neurons. J. Physiol. (Lond) 485:373-381.
28. Leranth, C., Z. Szeidemann, M. Hsu, and G. Busáki (1996) AMPA receptors in the rat and primate hippocampus: A possible absence of GluR2/3 subunits in most interneurons. Neuroscience 70:631-652.
29. Liao, D., N.A. Hessler, and R. Mallow (1995) Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature 375:400-404.
30. Lipski, J., and E.G. Merill (1980) Electrophysiological demonstration of the projection from expiratory neurones in rostral medulla to contralateral dorsal respiratory group. Brain Res. 197:521-524.
31. Liu, G., J.L. Feldman, and J.C. Smith (1990) Excitatory amino acid-mediated transmission of inspiratory drive to phrenic motoneurons. J. Neurophysiol. 64:423-436.
32. McAllen, R.M. (1986) Location of neurones with cardiovascular and respiratory function, at the ventral surface of the cat's medulla. Neuroscience 18:43-49.
33. McCrimmon, D.R., J.L. Feldman, and D.F. Speck (1986) Respiratory motoneuronal activity is altered by injections of picomoles of glutamate into cat brainstem. J. Neurosci. 6:2384-2392.
34. McCrimmon, D.R., J.C. Smith, and J.L. Feldman (1989) Involvement of excitatory amino acids in neurotransmission of inspiratory drive to spinal respiratory motoneurons. J. Neurosci. 9:1910-1921.
35. Mitchell, J.J., and K.J. Anderson (1991) Quantitative autoradiographic analysis of excitatory amino acid receptors in the cat spinal cord. Neurosci. Lett. 124: 269-272.
36. Monaghan, D.T., R.J. Bridges, and C.W. Cotman (1989) The excitatory amino acid receptors: Their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu. Rev. Pharmacol. Toxicol. 29:365-402.
37. Otsuka, H., S.G.E. Lindahl, H. Lagercrantz, and Y. Yamamoto (1994) Effects of NMDA and non-NMDA receptor antagonists on inspiratory neurons in the in vitro brainstem-spinal cord preparation of newborn rat. Neurosci. Lett. 171:94-96.
38. Patneau, D.K., L. Vyklicky, and M.L. Mayer (1993) Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate. J. Neurosci. 13:3496-3509.
39. Petralia, R.S., and R.J. Wenthold (1992) Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain. J. Comp. Neurol. 318:329-354.
40. Petralia, R.S., N. Yokotani, and R.J. Wenthold (1994) Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective antipeptide antibody. J. Neurosci. 14:667-696.
41. Pulsinelli, W.A., and J.B. Brierley (1979) A new model of bilateral hemispheric ischemia in the unanaesthetized rat. Stroke 10:267-72.
42. Richter, D.W., K. Ballanyi, and S.W. Schwarzacher (1992) Mechanisms of respiratory rhythm generation. Curr. Opin. Neurobiol. 281:788-793.
43. Richter, D.W., J. Champagnat, T. Jacqui, and R. Bernacka (1993) Calcium currents and calcium-dependent potassium currents in mammalian medullary respiratory neurons of the cat. J. Physiol. 470:23-33.
44. Robinson, D.L., and H.H. Ellenberger (1994) Distribution of AMPA receptor subunits within the phrenic nucleus and the ventral respiratory group in the rat. Soc. Neurosci. Abstr. 20:545.
45. Saji, M., and M. Miura (1990) Evidence that glutamate is the transmitter mediating respiratory drive from medullary premotor neurons to phrenic motoneurons: A double-labeling study in the rat. Neurosci. Lett. 115:177-182.
46. Sather, W., S. Dieudonne, J.F. MacDonald, and P. Ascher (1992) Activation and desensitization of N-methyl-D-aspartate receptors in nucleated inside-out patches from mouse neurones. J. Physiol. 450:643-672.
47. Schmued, L.C., and J.H. Fallon (1986) Fluoro-Gold: A new fluorescent retrograde axonal tracer with numerous unique properties. Brain Res. 377:147-154.
48. 3H] kainate binding sites in the normal human spinal cord, brainstem and motor cortex. Brain Res. 641: 39-45.
49. Siegel, S.J., N. Brose, W.G. Janssen, G.P. Gasic, R. Jahn, S.F. Heinemann, and J.H. Morrison (1994) Regional, cellular, and ultrastructural distribution of N-methyl-D-aspartate receptor subunit 1 in monkey hippocampus. Proc. Natl. Acad. Sci. USA 91:564-568.
50. Smith, J.C., H.H. Ellenberger, K. Ballanyi, D.W. Richter, and J.L. Feldman (1991) Pre-Bötzinger complex: A brainstem region that may generate respiratory rhythm in mammals. Science 254:726-729.
51. Tölle, T.R., A. Berthele, W. Zieglgänsberger, P.H. Seeburg, and W. Wisden (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13:5009-5028.
52. Wessendorf, M.W., and T.C. Brelje (1992) Which fluorophore is brightest? A comparison of the staining obtained using fluorescein, tetramethylrhodamine, lissamine rhodamine, Texas red, and cyanine 3.18. Histochem. J. 98:81-85.
53. Westbrook, G. (1994) Glutamate receptor update. Curr. Opin. Neurobiol. 4:337-346.