New β-lactam monocyclic inhibitors of human elastases: Synthesis and anti-elastase properties of 1-carbamoyl-4-methyleneaminoxyazetidinone derivatives

European Journal of Medicinal Chemistry

Volumn 32, Issue 11, 1997, Pages 889-894

  Balsamo, A ^a   Asti, C ^b   Belfiore, M S ^a   Brandolini, L ^b   Cercignani, G ^a   Gentili, D ^a   Macchia, M ^a   Mantovanini, M ^b   Orlandini, E ^a   Rossello, A ^a  

^a UNIVERSITY OF PISA   (Italy)

^b Chemistry Section   (Italy)

Author keywords

1 carbomoyl 4 methyleneaminoxyazetidinone derivative; Elastase inhibitor; lactam monocyclic inhibitor

Indexed keywords

ELASTASE; ELASTASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKOCYTE; LUNG HEMORRHAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SWINE;

EID: 0030670950     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(97)82774-2     Document Type: Article

References (18)

1. Belfiore MS, Gentili D, Macchia B et al (1995) II Congresso Congiunto Italiano-Spagnolo di Chimica Farmaceutica Soc Chim Ital, Ferrara, August 30-September 3, abstr P137
2. Snider GL, Ciccolella DE, Morris SM et al (1991) Ann NY Acad Sci 624, 45-59
3. Merritt TA, Cochrane CG, Holcomb K et al (1983) J Clin Invest 72, 656-666
4. Jackson AH, Hill SL, Afford SC et al (1984) J Resp Dis 65, 114-124
5. Stockley R A, Hill SL, Burnett D et al (1991 ) Ann NY Acad Sci 624, 257-266
6. Hagmann WK, Kissinger AL, Shah S K et al (1993) J Med Chem 36, 771-777
7. Doherty JB, Shah SK, Finke PE et al (1993) Proc Natl Acad Sci USA 90, 8727-8731
8. Shah SK, Dorn CP Jr, Finke PE et al (1992) J Med Chem 35, 3745-3754
9. Hudson RF, Green M (1962) J Chem Soc 1055
10. Jencks WP, Gilchrist M (1968) J Am Chem Soc 90, 2622
11. Edwards JO, Pearson RG (1962) J Am Chem Soc 84, 16-24
12. Staude, Patat (1967) In: The Chemistry of Ether Linkage (Patai, ed) Wiley, New York, 22-46
13. Clauss K, Grimm D, Prossel G et al (1974) Liebigs Ann Chem 539-560
14. Vogel AI (1956) Practical Organic Chemistry. Longmans Green, London, 719
15. Green BG, Weston H, Ashe BM et al (1991) Archiv Biochem Biophys 286, 284-292
16. Firestone RA, Barker PL, Pisano JM et al (1990) Tetrahedron 46, 2255-2262
17. Nakajima K, Powers JC, Ashe BM et al (1979) J Biol Chem 254, 4027-4032
18. Bode W, Meyer E Jr, Powers JC (1989) Biochemistry 28, 1951-1963