Fibronectin fragment-facilitated retroviral transfer of the Glutathione-S-Transferase Π gene into CD34+ cells to protect them against alkylating agents

Human Gene Therapy

Volumn 8, Issue 16, 1997, Pages 1901-1910

  Kuga, Takashi ^a   Sakamaki, Sumio ^a   Matsunaga, Takuya ^a   Hirayama, Yasuo ^a   Kuroda, Hiroyuki ^a   Takahashi, Yasuo ^a   Kusakabe, Toshiro ^a   Kato, Ikunoshin ^a,b   Niitsu, Yoshiro ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TAKARA SHUZO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYLATING AGENT; CD34 ANTIGEN; CYCLOPHOSPHAMIDE; DOXORUBICIN; FIBRONECTIN; GLUTATHIONE TRANSFERASE; INTERLEUKIN 6; STEM CELL FACTOR;

ARTICLE; CHEMOTHERAPY; GENE THERAPY; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MULTIDRUG RESISTANCE; NONHUMAN; RETROVIRUS;

UNIDENTIFIED RETROVIRUS;

EID: 0030670945     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1997.8.16-1901     Document Type: Article

References (4)

1. BAN, N., TAKAHASHI, Y., TAKAYAMA, T., KURA, T., KATAHIRA, T., SAKAMAKI, S., and NIITSU, Y. (1996). Transfection of Glutathione S-transferase (GST)-π antisense cDNA increases sensitivity of colon cancer cell line to adriamycin, cisplatin, melphalan and etoposide. Cancer Res. 56, 3577-3582.
2. BATIST, G., TULPULES, A., and SHINA, B.K. (1986). Overexpression of a novel anionic glutathione transferase in multidrug-resistant human breast cancer cells. J. Biol. Chem. 261, 15544-15549.
3. BERTOLINI, F., DE MONTE, L., CORSINI, C., LAZZARI, L., LAURI, E., SOLOGO, D., WARD, M., BANK, A., and MALAVASI, F. (1994). Retrovirus-mediated transfer of the multidrug resistance gene into human haemopoietic progenitor cells. Br. J. Haematol. 88, 318-324.
4. BLACK, S.M., BEGGS, J.D., HAYES, J.D., BARTOSZEK, A., MURAMATSU, M., SAKAI, M., and WOLF, C.R. (1988). Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil. Biochem. J. 268, 309-315.