Homologous recombination partly restores the secretion defect of underglycosylated acid phosphatase in yeast

Current Genetics

Volumn 32, Issue 3, 1997, Pages 190-196

  Prætorius Ibba, Mette ^a,b,d   Monnet, Gilles ^a,e   Meyhack, Bernd ^a   Kielland Brandt, Morten ^b   Nilsson Tillgren, Torsten ^c   Hinnen, Albert ^a,f  

^a CIBA GEIGY LTD   (Switzerland)

^b CARLSBERG LABORATORY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d YALE UNIVERSITY   (United States)

^e NESTLÉ RESEARCH CENTER   (Switzerland)

^f HANS KNÖLL INSTITUTE   (Germany)

Author keywords

Intrachromosomal recombination; PH03; PH05; Tandem repeats

Indexed keywords

ACID PHOSPHATASE; FUNGAL DNA; GLYCOSYLATED PROTEIN;

ARTICLE; CONTROLLED STUDY; ENZYME GLYCOSYLATION; ENZYME RELEASE; FUNGAL GENETICS; FUNGUS MUTANT; GENE; GENE CONVERSION; GENETIC RECOMBINATION; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SISTER CHROMATID EXCHANGE; TANDEM REPEAT;

ACID PHOSPHATASE; BASE SEQUENCE; CARRIER PROTEINS; GENES, FUNGAL; GLYCOSYLATION; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; PHOSPHATE TRANSPORT PROTEINS; POLYMERASE CHAIN REACTION; RECOMBINATION, GENETIC; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VARIATION (GENETICS);

FUNGI; SACCHAROMYCES CEREVISIAE;

EID: 0030670853     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002940050265     Document Type: Article

References (27)

1. Aguilera A, Klein HL (1989) Yeast intrachromosomal recombination: long gene-conversion tracts are preferentially associated with reciprocal exchange and require the RAD1 and RAD3 gene product. Genetics 123:683-694
2. Arima K, Oshima T, Kubota I, Nakarnura N, Mizunaga T, Toh-e A (1983) The Nucleotide sequence of the yeast PHO5 gene: a putative precursor of repressible acid phosphatase contains a signal peptide. Nucleic Acids Res 11:1657-1672
3. Ausubel FM, Brent R, Kingston RE, Moore DD, Seidman JG, Smith JA, Struhl K (1990) Current protocols in molecular biology. Wiley Interscience 2:13.3.1
4. Bajwa W, Meyhack B, Rudolph H, Schweingruber A-M, Hinnen A (1984) Structural analysis of the two tandemly repeated acid-phosphatase genes in yeast. Nucleic Acids Res 12:7721-7737
5. Bostian KA, Lemire JJ, Cannon LE, Halvorson HO (1980) In vitro synthesis of the repressible yeast acid phosphatase: identification of multiple mRNAs and products. Proc Natl Acad Sci USA 77:4504-4508
6. Haguenauer-Tsapis R, Hinnen A (1984) A deletion that includes the signal peptidase cleavage site impairs processing, glycosylation and secretion of cell-surface yeast acid phosphatase. Mol Cell Biol 4:2668-2675
7. Haynes RH, Kunz BA (1981) DNA repair and mutagenesis in yeast. In: Strathern JN, Jones EW, Broach JR (eds) The molecular biology of the yeast Saccharomyces: life cycle and inheritance. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 371-414
8. Hinnen A, Bajwa W, Meyhack B, Rudolph H (1987) Molecular aspects of acid phosphatase synthesis in Saccharomyces cerevisiae. In: Torriani-Gorini A, Rothman FG, Silver S, Wright A, Yagil E (eds) Phosphate metabolism and cellular regulation in microorganisms. American Society for Microbiology, Washington DC, pp 56-62
9. Jackson JA, Fink GR (1981) Gene conversion between duplicated genetic elements in yeast. Nature 292:306-311
10. Lichten M, Haber JE (1989) Position effects in ectopic and allelic mitotic recombination in Saccharomyces cerevisiae. Genetics 123:261-268
11. Meyhack B, Bajwa W, Rudolph H, Hinnen A (1982) Two yeast acid-phosphatase structural genes are the result of a tandem duplication and show different degrees of homology in their promoter and coding sequences. EMBO J 1:675-680
12. Petes TD, Hill CW (1988) Recombination between repeated genes in microorganisms. Annu Rev Genet 22: 147-168
13. Petes TD, Malone RE, Symington LS (1991) Recombination in yeast. In: Broach JR, Pringle JR, Jones EW (eds) The molecular biology of the yeast Saccharomyces: genome dynamics, protein synthesis and energetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp 407-521
14. Prætorius M (1995) Acid phosphatase in Saccharomyces cerevisiae. A study of protein folding, secretion and degradation. PhD Thesis, University of Copenhagen
15. Riederer MA (1991) Influence of N-linked glycosylation on the efficiency of secretion of yeast acid phosphatase. PhD Thesis, University of Basel
16. Riederer MA, Hinnen A (1991) Removal of N-glycosylation sites of the yeast acid phosphatase severely affects protein folding. J Bacteriol 173:3539-3546
17. Rose MD, Winston F, Hieter P (eds) (1990) Methods in yeast genetics. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
18. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York
19. Schiestl RH, Igarashi S, Hastings PJ (1988) Analysis of the mechanism for reversion of a disrupted gene. Genetics 119:237-247
20. Sengstag C, Hinnen A (1987) The sequence of the Saccharomyces cerevisiae gene PHO2 codes for a regulatory protein with unusual amino-acid cmposition. Nucleic Acids Res 15:233-246
21. Sherman F (1991) Getting started with yeast. Methods Enzymol 194:3-21
22. Sherman F, Fink GR, Lawrence CW (eds) (1974) Methods in yeast genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
23. Schweingruber ME, Fluri R, Maundrell K, Schweingruber A-M, Dumermuth E (1986) Identification and characterization of the thiamin-repressible acid phosphatase in yeast. J Biol Chem 261: 15877-15882
24. Toh-e A, Kakimoto S, Oshima Y (1975) Genes coding for the structure of the acid phosphatases in Saccharomyces cerevisiae. Mol Gen Genet 143:65-70
25. Venter U, Hörz W (1989) The acid-phosphatase genes PHO10 and PHO11 in S. cerevisiae are located at the telomeres of chromosomes VIII and I. Nucleic Acids Res 17: 1353-1369
26. Willis KK, Klein HL (1987) Intrachromosomal recombination in Saccharomyces cerevisiae: reciprocal exchange in an inverted repeat and associated gene conversion. Genetics 117:633-643
27. Winther JR, Stevens TH, Kielland-Brandt MC (1991) Yeast carboxypeptidase Y requires glycosylation for efficient intracellular transport, but not for vacuolar sorting, in vivo stability, or activity. Eur J Biochem 197:681-689