Inflammation: The protein C pathway

Fibrinolysis and Proteolysis

Volumn 11, Issue SUPPL. 1, 1997, Pages 143-148

  Esmon, C T ^a,b,c,d   Fukudome, K ^a   Mather, T ^e   Bode, W ^e   Esmon, N L ^a,b   Regan, L M ^d   Stearns Kurosawa, D J ^a   Kurosawa, S ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b Departments of Pathology   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CELL RECEPTOR; CYTOKINE; PROTEIN C; THROMBOMODULIN; TUMOR NECROSIS FACTOR;

BABOON; BLOOD CLOTTING; CONFERENCE PAPER; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTHELIUM CELL; GRAM NEGATIVE SEPSIS; HUMAN; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RODENT;

EID: 0030669788     PISSN: 13690191     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0268-9499(97)80041-0     Document Type: Conference Paper

References (25)

1. Esmon C T, Owen W G. Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci (USA) 1981; 78: 2249-2252.
2. Hanson S R, Griffin J H, Harker L A, Kelly A B, Esmon C T, Gruber A. Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates. J Clin Invest 1993; 92: 2003-2012.
3. Espana F, Zuazu I, Vicente V, Estelies A, Marco P, Aznar J. Quantification of circulating activated protein C in human plasma by immunoassays - Enzyme levels are proportional to total protein C levels. Thromb Haemost 1996; 75: 56-61.
4. Esmon C T, Schwarz H P. An update on clinical and basic aspects of the protein C anticoagulant pathway. Trends Cardiovasc Med 1995; 5: 141-148.
5. Conard J, Bauer K A, Gruber A, Griffin J H, Schwarz H P, Horellou M H, Samama M M, Rosenberg R D. Normalization of markers of coagulation activation with a purified protein C concentrate in adults with homozygous protein C deficiency. Blood 1993; 82: 1159-1164.
6. Dreyfus M, Magny J F, Bridey F, Schwarz H P, Planché C, Dehan M, Tchernia G. Treatment of homozygous protein C deficiency and neonatal purpura fulminans with a purified protein C concentrate. N Engl J Med 1991; 325: 1565-1568.
7. Taylor F B Jr., Chang A, Hinshaw L B, Esmon C T, Archer L T, Beller B K. A model for thrombin protection against endotoxin. Thromb Res 1984; 36: 177-185.
8. Comp P C, Jacocks R M, Ferrell G L, Esmon C T. Activation of protein C in vivo. J Clin Invest 1982; 70: 127-134.
9. Taylor F, Chang A, Ferrell G, Mather T, Catlett R, Blick K, Esmon C T. C4b-binding protein exacerbates the host response to Escherichia coli. Blood 1991; 78: 357-363.
10. Taylor F B Jr., Chang A, Esmon C T, D'Angelo A, Vigano-D'Angelo S, Blick K E. Protein C prevents the coagulopathic and lethal effects of E. coli infusion in the baboon. J Clin Invest 1987; 79: 918-925.
11. Grey S T, Tsuchida A, Hau H, Orthner C L, Salem H H, Hancock W W. Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to IPS, IFN-gamma, or phorbol ester. J Immunol 1994; 153: 3664-3672.
12. Grinnell B W, Hermann R B, Yan S B. Human protein C inhibits selectin-mediated cell adhesion. Role of unique fucosylated oligosaccharide. Glycobiology 1994; 4: 221-226.
13. Esmon C T. Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 1995; 9: 946-955.
14. Fukudome K, Esmon C T. Identification, cloning and regulation of a novel endothelial cell protein C/activated protein C receptor. J Biol Chem 1994; 269: 26486-26491.
15. Fukudome K, Esmon C T. Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR. J Biol Chem 1995; 270: 5571-5577.
16. + T cells. Nature 1994; 372: 691-694.
17. Germain R N. MHC-dependent antigen processing and peptide presentation: Providing ligands for T lymphocyte activation. Cell 1994; 76: 287-299.
18. Calabi F, Yu C Y, Bilsland C A G, Milstein C. CD1: From structure to function. In: Srivastava R, Ram B P, Tyle P (eds). Immunogenetics of the major histocompatibility complex. New York, VCH Publishing; 1991: 215-243.
19. Rothbarth K, Petzelt C, Lu X, Todorov I T, Joswig G, Pepperkok R, Ansorge W, Werner D. cDNA-derived molecular characteristics and antibodies to a new centrosome-associated and G2/M phase-prevalent protein. J Cell Sci 1993; 104: 19-30.
20. Fukudome K, Kurosawa S, Stearns-Kurosawa D J, Regan L, Esmon C T. Cell surface expression of the endothelial cell protein C/activated protein C receptor (EPCR). Blood 1995; 197a (Abstract)
21. Mathews I I, Padmanabhan K P, Tulinsky A. Structure of a nonadecapeptide of the fifth EGF domain of thrombomodulin complexed with thrombin. Biochemistry 1994; 33: 13547-13552.
22. Jakubowski H V, Kline M D, Owen W G. The effect of bovine thrombomodulin on the specificity of bovine thrombin. J Biol Chem 1986; 261: 3876-3882.
23. Stubbs M T, Oschkinat H, Mayr I, Huber R, Angliker H, Stone S R, Bode W. The interaction of thrombin with fibrinogen. A structural basis for its specificity. Eur J Biochem 1992; 206: 187-195.
24. 2+ for rapid activation by the thrombin-thrombomodulin complex. J Biol Chem 1994; 269: 3151-3154.
25. Mather T, Hof P, Bode W, Huber R, Foundling S, Esmon C. The structure of Gla-domainless activated protein C. Twenty-first EMBO Symposium 'Structure and Function of Proteins' 1995; 151. (Abstract)