Bioactivation and inactivation of aflatoxin B1 by human, mouse and rat liver preparations: Effect on SCE in human mononuclear leucocytes

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 373, Issue 2, 1997, Pages 257-264

  Wilson, Andrew S ^a   Williams, Dominic P ^a   Davis, Carl D ^a   Tingle, Malcolm D ^a   Park, B Kevin ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Aflatoxin B1; CYP1A2; Epoxide hydrolase; GST M1; Mononuclear leucocytes; SCE

Indexed keywords

AFLATOXIN B1; GLUTATHIONE;

ADULT; ANIMAL TISSUE; ARTICLE; BIOASSAY; DRUG INACTIVATION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LEUKOCYTE; LIVER CYTOSOL; LIVER METABOLISM; LIVER MICROSOME; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; RAT; SISTER CHROMATID EXCHANGE; SPECIES DIFFERENCE;

AFLATOXIN B1; ANIMALS; BIOTRANSFORMATION; CYTOPLASM; GLUTATHIONE; HUMANS; LEUKOCYTES, MONONUCLEAR; MICE; MICROSOMES, LIVER; MUTAGENICITY TESTS; RATS; SISTER CHROMATID EXCHANGE; SPECIES SPECIFICITY;

ANIMALIA;

EID: 0030669603     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0027-5107(96)00205-9     Document Type: Article

References (30)

1. Smith, D.A. (1991) Species differences in metabolism and pharmacokinetics. Are we closer to an understanding? Drug Metab. Rev., 23, 355-373.
2. 1, naphthalene and tamoxifen using human liver microsomes and human lymphocytes. Hum. Exp. Toxicol., 14, 507-515.
3. Portman, R.S., Plowman, K.M. and Campbell, T.C. (1970) On mechanisms affecting species susceptibility to aflatoxin. Bioch. Biophys. Acta, 208, 487-495.
4. 1, a hepatocarcinogen in the infant mouse. Cancer Res., 32, 2289-2291.
5. Wogan, G. (1973) Aflatoxin carcinogenesis, in: H. Busch (Ed.), Methods in Cancer Research. Academic Press. New York, pp. 309-344.
6. Peers, F.G. and Linsell, C.A. (1973) Dietary aflatoxins and liver cancer - a population study based in Kenya. Br. J. of Cancer. 27, 473-483.
7. Bulatao-Jayme, J., Almero, E.M., Castro, M.C.A., Jardeleza, M.T.R. and Salamat, L.A. (1982) A case-control dietary study of primary liver cancer risk from aflatoxin exposure. Inter. J. Epidemiol., 11, 112.
8. Peers, F.G., Bosch, X., Kaldor, J., Linsell, A. and Pluumen, H. (1987) Aflatoxin exposure, hepatitis B virus infection and liver cancer in Swazailand. Intern. J. Cancer, 39, 545-553.
9. Groopman, J.D. and Donahue, K.F. (1988) Aflatoxin, a human carcinogen: determination in foods and biological samples by monoclonal antibody affinity. J. Assoc. Anal. Chem., 71, 861-867.
10. Gill, H.J., Tingle, M.D. and Park, B.K. (1995) W-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: Implications for inhibition of haemotoxicity. Br. J. Clin. Pharmacol., 40, 531-538.
11. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951) Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193, 265-279.
12. Riley, R.J., Lambert, C., Maggs, J.L., Kitteringham, N.R. and Park, B.K. (1988) An in vitro study of the microsomal metabolism and cellular toxicity of phenytoin, sorbinil and mianserin. Br. J. Clin. Pharmacol., 26, 577-588.
13. Spaldin, V., Madden, S., Adams, D.A., Edwards, R.J., Davies, D.S. and Park, B.K. (1995). Determination of human hepatic cytochrome P4501A2 activity in vitro. Use of tacrine as an isozyme-specific probe. Drug Metab. Disp., 23, 929-934.
14. Davis, C.D., Pirmohamed, M., Kitteringham, N.R., Allott, R.L., Smith, D. and Park, B.K. (1995) Kinetic parameters of lymphocyte microsomal epoxide hydrolase in carbamazepine hypersensitive patients: Assessment by radiometric HPLC. Biochem. Pharmacol., 50, 1361-1366.
15. Brockmöller, J., Gross, D., Kerb, R., Drakoulis, N. and Roots, I. (1992) Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione S-transferase class mu gene detected by polymerase chain reaction. Biochem. Pharmacol., 43, 657-650.
16. Green, V.J., Pirmohamed, M., Kitteringham, N.R., Knapp, M.J. and Park, B.K. (1995) Glutathione S-transferase μ genotype (GST M1 × O) in alzheimer's patients with tacrine transaminitis. Br. J. Clin. Pharmacol., 39, 411-415.
17. Dean, B.J. and Danford, N. (1984) Chemically induced chromosome damage, in: S. Venitt and J.M. Parry (Eds.), Mutagenicity Testing: A Practical Approach. IRL press, Oxford pp. 187-232.
18. Goto, K., Maeda, S., Kano, Y. and Sugiyama, T. (1978) Factors involved in differential Giemsa staining of sister chromatids. Chromosoma, 66, 351-359.
19. Cotgreave, I.A. and Moldeus, P. (1986) Methodologies for the application of monobimane to the simultaneous analysis of soluble and protein thiol components of biological systems J. Biochem. Biophys. Methods, 13, 231-249.
20. Tingle, M.D., Jewell, H., Maggs, J.L., O'Neill, P. and Park, B.K. (1995) The bioactivation of amodiaquine by human polymorphonuclear leucocytes in vitro: Chemical mechanisms and the effects of fluorine substitution. Biochem. Pharmacol., 50 (7), 1113-1119.
21. Gallagher, E.P., Wienkers, L.C., Stapleton, P.L., Kunze, K.L. and Eaton, D.L. (1994) Role of human microsomal and human complementary DNA-expressed cytochromes P-450 1A2 and P-450 3A4 in the bioactivation of aflatoxin B1. Cancer Res., 54, 101-108.
22. Eaton D.L. and Gallagher E.P. (1994) Mechanisms of aflatoxin carcinogenesis. Annu. Rev. Pharmacol. Toxicol., 34, 135-172.
23. Kitteringham, N.R., Davis, C.D., Howard, N., Pirmohamed, M. and Park, B.K. (1996) Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies with cis-stilbene oxide, carbamazepine-10, 11-epoxide and naphthalene. J. Pharmacol. Exp. Ther. (in press).
24. 1. Proc. Natl. Acad. Sci. (USA), 92, 2384-2387.
25. Busby, Jr. W.F. and Wogan, G.N. (1984) Aflatoxins. in: C.E. Searle (Ed.), Chemical Carcinogens American Chemical Society, Washington DC, pp. 945-1136.
26. 1 to DNA, RNA, polyribonucleotide and protein in vitro. Chem. Biol. Interact., 6, 125-129.
27. 1 in the rat and mouse. Toxicol. Appl. Pharmacol., 90, 401-409.
28. 1 exo-epoxide: association with reduced levels of hepatic aflatoxin-DNA adducts in vivo. Drug Metab. Disp., 22, 392-399.
29. Liu, Y.H., Taylor, J., Linko, P., Lucier, G.W. and Thompson, C.L. (1991) Glutathione S-transferase μ in human lymphocytes and liver, role in modulating formation of carcinogen derived DNA adducts. Carcinogenesis, 12, 2269-2275.
30. 1-epoxide and other substrates. Pharmacogenesis, 5, 224-233.