Inhibition of PAH transport by parathyroid hormone in OK cells: Involvement of protein kinase C pathway

American Journal of Physiology - Renal Physiology

Volumn 273, Issue 5 42-5, 1997, Pages

  Nagai, Junya ^a   Yano, Ikuko ^a   Hashimoto, Yukiya ^a   Takano, Mikihisa ^a   Inui, Ken Ichi ^a  

^a KYOTO UNIVERSITY HOSPITAL   (Japan)

Author keywords

Hormonal control; Opossum kidney cell; Organic anion transport; Renal secretion

Indexed keywords

4 AMINOHIPPURIC ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; PARATHYROID HORMONE; PROTEIN KINASE C; PROTEIN KINASE C ACTIVATOR; PROTEIN KINASE C INHIBITOR; STAUROSPORINE;

ANIMAL CELL; ANION TRANSPORT; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; HORMONAL REGULATION; KIDNEY EPITHELIUM; KIDNEY TUBULE EXCRETION; NONHUMAN; OPOSSUM; PRIORITY JOURNAL; SECOND MESSENGER; TRANSCYTOSIS;

EID: 0030669602     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.1997.273.5.f674     Document Type: Article

References (18)

1. Arao, M., T. Yamaguchi, T. Sugimoto, M. Fukase, and K. Chihara. Involvement of protein kinase C in the stimulation of sodium-dependent phosphate transport by parathyroid hormone in osteoblast-like cells. Eur. J. Endocrinol. 131: 646-651, 1994.
2. Bradford, M. M. A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254, 1976.
3. Dunlay, R., and K. Hruska. PTH receptor coupling to phospholipase C is an alternate pathway of signal transduction in bone and kidney. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F223-F231, 1990.
4. Friedman, P. A., B. A. Coutermarsh, S. M. Kennedy, and F. A. Gesek. Parathyroid hormone stimulation of calcium transport is mediated by dual signaling mechanisms involving protein kinase A and protein kinase C. Endocrinology 137: 13-20, 1996.
5. Halpin, P. A., and J. L. Renfro. Renal organic anion secretion: evidence for dopaminergic and adrenergic regulation. Am. J. Physiol. 271 (Regulatory Integrative Comp. Physiol. 40): R1372-R1379, 1996.
6. Hayes, G., A. E. Busch, F. Lang, J. Biber, and H. Murer. Protein kinase C consensus sites and the regulation of Na/Pi-cotransport (NaPi-2) expressed in Xenopus laevis oocytes. Pflügers Arch. 430: 819-824, 1995.
7. + exchange in opossum kidney cells by parathyroid hormone, cyclic AMP and phorbol esters. Pflügers Arch. 415: 461-470, 1990.
8. Hori, R., M. Okamura, A. Takayama, K. Hirozane, and M. Takano. Transport of organic anion in the OK kidney epithelial cell line. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F975-F980, 1993.
9. Jüppner, H., A.-B. Abou-Samra, M. Freeman, X. F. Kong, E. Schipani, J. Richards, L. F. Kolakowski, J. J. Hock, J. T. Potts, H. M. Kronenberg, and G. V. Segre. A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. Science 254: 1024-1026, 1991.
10. Kippen, I., K. Kurokawa, and J. R. Klinenberg. Stimulation of p-aminohippuric acid in rabbit kidney cortex by parathyroid hormone and adenosine 3′,5′-cyclic monophosphate. Biochem. Pharmacol. 25: 219-220, 1976.
11. Koyama, H., C. Goodpasture, M. M. Miller, R. L. Teplitz, and A. D. Riggs. Establishment and characterization of a cell line from the American opossum (Didelphys virginiana). In Vitro (Rockville) 14: 239-246, 1978.
12. Malmstrsm, K., G. Stange, and H. Murer. Identification of proximal tubular transport functions in the established kidney cell line, OK. Biochim. Biophys. Acta 902: 269-277, 1987.
13. 2+ is related to inhibition of Pi transport in OK cells. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F485-F493, 1990.
14. Muff, R., J. A. Fischer, J. Biber, and H. Murer. Parathyroid hormone receptors in control of proximal tubule function. Annu. Rev. Physiol. 54: 67-79, 1992.
15. Murer, H., A. Werner, S. Reshkin, F. Wuarin, and J. Biber. Cellular mechanisms in proximal tubular reabsorption of inorganic phosphate. Am. J. Physiol. 260 (Cell Physiol. 29): C885-C899, 1991.
16. Nagai, J., M. Takano, K. Hirozane, M. Yasuhara, and K. Inui. Specificity of p-aminohippurate transport system in the OK kidney epithelial cell line. J. Pharmacol. Exp. Ther. 274: 1161-1166, 1995.
17. Ohoka, K, M. Takano, T. Okano, S. Maeda, K. Inui, and R. Hori. p-Aminohippurate transport in rat renal brush-border membranes: a potential-sensitive transport system and an anion exchanger. Biol. Pharm. Bull. 16: 395-401, 1993.
18. Pritchard, J. B. Intracellular α-ketoglutarate controls the efficacy of renal organic anion transport. J. Pharmacol. Exp. Ther. 274: 1278-1284, 1995.