Beneficial effects of clonidine in streptozotocin-induced diabetes and DOCA-hypertensive rats

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 10, 1997, Pages 1030-1035

  Satia, Milan C ^a,b   Damani, Rushabh R ^a   Goyal, Ramesh K ^a  

^a L M COLLEGE OF PHARMACY   (India)

^b ZYDUS RESEARCH CENTRE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CLONIDINE; DEOXYCORTICOSTERONE ACETATE; GLUCOSE; INSULIN; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRADYCARDIA; CONTROLLED STUDY; DRUG EFFECT; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSURIA; HEART LEFT VENTRICLE FILLING PRESSURE; HEART LEFT VENTRICLE PRESSURE; HEART VENTRICLE HYPERTROPHY; HYPERCHOLESTEROLEMIA; HYPERGLYCEMIA; HYPERTENSION; HYPERTRIGLYCERIDEMIA; HYPOINSULINEMIA; HYPOTHYROIDISM; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STREPTOZOCIN DIABETES; WEIGHT REDUCTION;

EID: 0030668872     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06036.x     Document Type: Article

References (35)

1. Albrink, M. J., Lavietes, P. H., Man, E. B. (1963) Vascular disease and serum lipids in diabetes mellitus: observations over thirty years (1931-1961). Arch. Intern. Med. 58: 305-323
2. Banerjee, S. K. (1983) Comparative studies of atrial and ventricular myosin from normal thyrotoxic and thyroidectomized rabbits. Circ. Res. 52: 131-136
3. Bangaru, R. A., Lakkad, N. B., Goyal, R. K. (1990) Effects of chronic atenolol treatment on diabetes-induced cardiac depression and other complications. Indian J. Pharmacol. 23: 33-34
4. Bolton, S. (1984) In: Pharmaceutical Statistics: Practical and Clinical Application. 4th edn, Marcel Dekker, New York, pp 218-232
5. Bunag, R. D., Tomita, T., Saski, S. (1982) Streptozotocin diabetic rats are hypertensive despite reduced hypothalamic responsiveness. Hypertension 4: 556-565
6. Cavaliere, T. A., Taylor, D. G., Kerwin, L. J., Antonaccia, M. J., (1980) Cardiovascular effects of alloxan diabetes in normotensive and spontaneously hypertensive rats. Pharmacology 20: 211-223
7. Dillman, W. H. (1982) Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats. Metabolism 31: 199-204
8. Factor, S. M., Minase, T., Sonnenblick, E. H. (1980) Clinical and morphological features of human hypertensive diabetic cardiomyopathy. Am. Heart J. 99: 446-458
9. Fuller, J. H., Shipley, M. J., Rose, G., Jerrtt, R. J., Keen, H. (1983) Mortality from coronary disease and stroke in relation to degree of glycaemia. The Whitehall study. Br. Med. J. 287: 867-878
10. Goyal, R. K., McNeill, J. H. (1985) Effect of triiodo-1-thyronine treatment on cardiac responsiveness to methoxamine in streptozotocin-induced diabetic rats. Fed. Proc. 44: 7241
11. Haeusler, G., Finch, L. (1972) On the nature of the central hypotensive effect of clonidine and methyldopa. J. Pharmacol. 3: 544-545
12. Haller, H., Lindschau, C., Quass, P., Distler, A. (1991) High glucose concentration(s) increase protein kinase C activity in vascular smooth muscle cells. J. Hypertens. 10: 145A
13. Hebden, R. A., Todd, H. E., Tang, C., Goven, B., McNeill, J. H. (1990) Association of DOCA hypertension with induction of atherosclerosis in rats with short-term diabetes mellitus. Am. J. Physiol. 258: R1042-R1050
14. Hermiller, J. B., Magorien, R. D., Leithe, M. E., Unverferth, D. V., Leier, C. V. (1983) Clonidine in congestive heart failure: a vasodilator with negative inotropic effects. Am. J. Cardiol. 51: 791-795
15. Hofteizer, V., Carpenter, A. M. (1973) Comparison of streptozotocin-induced diabetes in the rat inducing volumetric quantitation of the pancreatic islets. Diabetologia 9: 178-184
16. Houston, M. C., Burger, C., Hays, J. T., Nadean, J., Swift, L., Olafsson, L. (1990) Effect of clonidine hydrochloride versus atenolol monotherapy on serum lipids lipid subfractions and apolipoproteins in mild hypertension. Am. Heart J. 120: 172-179
17. Ishii, K., Yamamoto, S., Kato, R. (1985) Increase in insulin response to glucose in rat chronically treated with clonidine. Naunyn Schmiedebergs Arch. Pharmacol. 328: 253-257
18. Lakkad, N. B., Bangaru, R. A., Rao, M. V., Goyal, R. K. (1992) Studies on the chronic treatment of enalapril and prazosin on diabetes-induced cardiac depression and other complications. Indian J. Pharmacol. 24: 62
19. Lancranjan, I., Marbach, P. (1977) New evidence for growth hormone modulation by the alpha-adrenergic system in man. Metabolism 26: 1225-1230
20. Lewis, S. J., Dunlop, M., Jarrott, B. (1989) Serum glucose and insulin levels in normotensive (WKY) and spontaneously hypertensive (SH) rats during and after the cessation of continuous (10 day) clonidine infusion. J. Pharm. Pharmacol. 41: 353-355
21. Malaisse, W. J., Malaisse-Large, F., King, S., Wright, P. H. (1968) Effect of growth hormone on insulin secretion. Am. J. Physiol. 215: 423-428
22. Martin, J. M., Akerblom, H. K., Garay, G. (1968) Insulin secretion in rats with elevated levels of circulating growth hormone due to MT-W15 tumor. Diabetes 17: 661-667
23. Nakaki, T., Nakadate, T., Ishii, K., Kato, R.(1981) Postsynaptic alpha-2 adrenergic receptors in isolated rat islets of Langerhans: inhibition of insulin release and cyclic 3′:5′-adenosine monophosphate accumulation. J. Pharmacol. Exp. Ther. 216: 607-612
24. Popovich, B. K. (1989) Diabetes decreases creatine kinase enzyme activity and mRNA level in the rat heart. Am. J. Physiol. 257: E573-E577
25. Rodrigues, B., Agrawal, D. K., McNeill, J. H. (1985) Are elevated plasma lipid and diabetic cardiomyopathy related? Fed. Proc. 44: 7291
26. Rodrigues, B., Goyal, R. K., McNeill, J. H. (1986) Effects of hydralazine on streptozotocin-induced diabetic rats: prevention of hyperlipidaemia and improvement of cardiac function. J. Pharmacol. Exp. Ther. 23: 292-299
27. Ruch, W., Jaton, A. L., Bucher, B., Marbach, P., Doepfher, W. (1976) Alpha adrenergic control of growth hormone in adult rats. Experientia 32: 520-530
28. Satia, M. C., Damani, R. H., Shukla, M. L., Gandhi, T. P., Goyal, R. K. (1995) Clonidine: still a better option for the treatment of diabetic hypertensive patients. Indian J. Pharmacol. 27: 64
29. Savarese, J. J., Berkowitz, B. A. (1979) Beta-adrenergic receptors decrease in diabetic rat hearts. Life. Sci. 25: 2075-2058
30. Scriabine, A., Stone, C. A., Stavorski, J. M. (1968) Studies on the mechanism of St 155-induced cardiac slowing in dogs. Pharmacologist 10: 156
31. Shah, T. S., Satia, M. C., Gandhi, T. P., Bangaru, R. A., Goyal, R. K. (1995) Effects of chronic nifedipine treatment on streptozotocin-induced diabetic rats. J. Cardiovasc. Pharmacol. 26: 6-12
32. Sosenko, J. M., Breshw, J. L., Miettimen, Q. S., Gabbay, K. H. (1980) Hyperglycaemia and plasma lipid levels: a prospective study of young insulin-dependent diabetic patients. N. Engl. J. Med. 302: 650-654
33. +2 activated ATPase of cardiac sarcoplasmic reticulum in hyper- and hypothyroidism. Biochem. Biophys. Acta. 252: 324-327
34. Vadlamudi, R. V. S. V., McNeill, J. H. (1983) Effect of experimental diabetes on rat cardiac cyclic AMP phosphodiesterase and inotropy. J. Pharmacol. Exp. Ther. 244: H844-H851
35. Weber, M. A. (1989) Clinical pharmacology of centrally acting antihypertensive agents. J. Clin. Pharmacol. 29: 598-602