Several receptor subtypes contribute to 5-hydroxytryptamine-induced secretion by rat ileum in-vitro

Journal of Pharmacy and Pharmacology

Volumn 49, Issue 11, 1997, Pages 1114-1120

  Hardcastle, J ^a   Hardcastle, P T ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHOXYTRYPTAMINE; GRANISETRON; KETANSERIN; PHENYLBIGUANIDE; RECEPTOR SUBTYPE; SEROTONIN; SEROTONIN 2 RECEPTOR; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; TETRODOTOXIN; TROPISETRON;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ILEUM; INTESTINE SECRETION; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; RECEPTOR DOWN REGULATION;

EID: 0030668626     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1997.tb06052.x     Document Type: Article

References (47)

1. Ayton, B., Hardcastle, J., Hardcastle, P. T., Carstairs, J. W. M. (1995) Comparison of the secretory actions of 5-hydroxytryptamine in the proximal and distal colon of the rat. J. Pharm. Pharmacol, 47: 34-41
2. Baird, A. W., Cuthbert, A. W. (1987) Neuronal involvement in type I hypersensitivity reactions in gut epithelia. Br. J. Pharmacol. 92: 647-655
3. Barry, M. K., Aloisi, J. D., Pickering, S. P., Yeo, C. J. (1994) Nitric oxide modulates water and electrolyte transport in the ileum. Ann. Surg. 219: 382-388
4. 3 receptor subtypes mediate cholera toxin-induced intestinal fluid secretion in the rat. Gastroenterology 99: 83-89
5. Beubler, E., Coupar, I. M., Hardcastle, J., Hardcastle, P. T. (1990) Stimulatory effects of 5-hydroxytryptamine on fluid secretion and transmural potential difference in rat small intestine are mediated by different receptor subtypes. J. Pharm. Pharmacol. 42: 35-39
6. Beubler, E., Schirgi-Degen, A., Gamse, R. (1993) Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum. Eur. J. Pharmacol. 248: 157-162
7. 4 receptor in the secretory response of the small intestine to 5-HT. Br. J. Pharmacol. 110: 927-928
8. Bradley, P. B., Engel, G., Fenuik, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., Saxena, P. R. (1986) Proposals for the classification and nomenclature of functional receptors for 5-hydroxytryptamine. Neuropharmacology 25: 563-576
9. 4 receptors in the isolated guineapig ileum. Naunyn Schmiedebergs Arch. Pharmacol. 345: 387-393
10. 4 receptor mediates 5-hydroxytryptamine-induced rise in short-circuit current in the human jejunum in-vitro. Surgery 116: 396-400
11. 4 receptors in the rat distal colon. Eur. J. Pharmacol. 298: 137-144
12. Bunce, K. T., Elswood, C. J., Ball, M. T. (1991) Investigation of the 5-hydroxytryptamine receptor mechanism mediating the short-circuit current response in rat colon. Br. J. Pharmacol. 102: 811-816
13. 4 receptor. Eur. J. Pharmacol. 241: 125-128
14. Castro, G. A., Harari, Y., Russell, D. (1987) Mediators of anaphylaxis-induced ion transport changes in small intestine. Am. J. Physiol. 253: G540-G548
15. Cooke, H. J. (1994) Neuroimmune signaling in regulation of intestinal ion transport. Am. J. Physiol. 266: G167-G178
16. Cooke, H. J., Carey, H. V. (1985) Pharmacological analysis of 5-hydroxytryptamine actions on guinea-pig ileal mucosa. Eur. J. Pharmacol. 111: 320-337
17. 4 receptors in guineapig ileum. Naunyn Schmiedebergs Arch. Pharmacol. 342: 9-16
18. Donowitz, M., Charney, A. N., Heffernan, J. M. (1977) Effect of serotonin treatment on intestinal transport in the rabbit. Am. J. Physiol. 232: E85-E94
19. Fozard, J. R. (1985) 5-Methoxytryptamine (5-MeOT) discriminates between excitatory neuronal 5-hydroxytryptamine (5-HT) receptors in the guinea-pig ileum. J. Pharmacologie. 16: 498
20. Fozard, J. R. (1987) 5-HT: the enigma variations. Trends Pharmacol. Sci. 8: 501-506
21. 4 receptors mediate the intestinal secretory response to 5-HT in rat in-vivo? J. Pharm. Pharmacol. 47: 213-218
22. Franks, C. M., Hardcastle, J., Hardcastle, P. T. (1996) Neural involvement in 5-hydroxytryptamine-induced electrogenic anion secretion in the rat intestine in-vivo. J. Pharm. Pharmacol. 48: 411-416
23. Grondahl, M. L., Hansen, M. B., Larsen, I. E., Skadhauge, E. (1996) Age and segmental differences in 5-hydroxytryptamine-induced hypersecretion in the pig small intestine. J. Comp. Physiol. B 166: 21-29
24. Hansen, M. B. (1994) ICS 205-930 reduces 5-methoxytryptamine-induced short-circuit current in stripped pig jejunum. Can. J. Physiol. Pharmacol. 72: 227-232
25. Hardcastle, J., Hardcastle, P. T. (1995) Evidence that the secretory response of rat intestine to 5-hydroxytryptamine in-vivo involves more than one 5-hydroxytryptamine receptor subtype. J. Pharm. Pharmacol. 47: 744-749
26. Hardcastle, J., Hardcastle, P. T. (1996a) Rat ileal response to 5-hydroxytryptamine (5-HT) in vitro involves more than one 5-HT receptor subtype. Physiol. Res. 45: 7P
27. Hardcastle, J., Hardcastle, P. T. (1996b) Comparison of the secretory response to 5-hydroxytryptamine (5-HT) in the jejunum and ileum of the rat in vitro. Physiol. Res. 45: 7P
28. Hardcastle, J., Hardcastle, P. T. (1997) 5-Hydroxytryptamine (5-HT) receptors mediating secretion by rat ileum in vitro. J. Physiol., 499: 107 p
29. Hardcastle, J., Hardcastle, P. T., Redfern, J. S. (1981) Action of 5-hydroxytryptamine on intestinal ion transport in the rat. J. Physiol. 320: 41-55
30. Hardcastle, J., Hardcasue, P. T., Carstairs, J. W. M., Franks, C. M. (1994) Is desensitization of intestinal 5-hydroxytryptamine receptors an in-vitro phenomenon? J. Pharm. Pharmacol. 46: 322-325
31. Hoyer, D., Schoeffter, P. (1991) 5-HT receptors: subtypes and second messengers. J. Rec. Res. 11: 197-214
32. Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., Humphrey, P. P. A. (1994) International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol. Rev. 46: 157-203
33. Hubel, K. (1984) Electrical stimulus-secretion coupling in rabbit ileal mucosa. J. Pharmacol. Exp. Ther. 231: 577-582
34. G-Nitro-L-arginine methyl ester modulates intestinal secretion and motility produced by carbachol. Eur. J. Pharmacol. 271: 31-35
35. Kadowaki, M., Gershon, M. D., Kuwahara, A. (1996) Is nitric oxide involved in 5-HT-induced fluid secretion in the gut? Behav. Brain Res. 73: 293-296
36. Kisloff, B., Moore, E. W. (1976) Effect of serotonin on water and electrolyte transport in the in-vivo rabbit small intestine. Gastroenterology 71: 1033-1038
37. Leff, P., Martin, G. R. (1988) The classification of 5-hydroxytryptamine receptors. Med. Res. Rev. 8: 187-202
38. McKay, D. M., Perdue, M. H. (1993) Intestinal epithelial function: the case for immunophysiological regulation. Cells and mediators. Dig. Dis. Sci. 38: 1377-1387
39. 4 agonist DAU 6236 in human colon. Med. J. Aust. 159: 834
40. Rao, R. K., Riviere, P. J. M., Pascaud, X., Junien, J. L., Porreca, F. (1994) Tonic regulation of mouse ileal ion transport by nitric oxide. J. Pharmacol. Exp. Ther. 269: 626-631
41. - secretion by a mechanism requiring a submucosal glutamate receptor and nitric oxide. J. Pharmacol. Exp. Ther. 274: 404-412
42. 3 receptor antagonism by BRL 43694 (granisetron). Eur. J. Pharmacol. 159: 113-124
43. Schirgi-Degen, A., Beubler, E. (1995) Significance of nitric oxide in the stimulation of intestinal fluid absorption in the rat jejunum in vivo. Br. J. Pharmacol. 114: 13-18
44. Scott, C. M., Bunce, K. T., Spraggs, C. F. (1992) Investigation of the 5-hydroxytryptamine receptor mediating the 'maintained' short-circuit current response in guinea-pig ileal mucosa. Br . J. Pharmacol. 106: 877-882
45. 2 receptor mediates serotonin-induced electrolyte transport in rat left colon. J. Surg. Res. 55: 323-329
46. Siriwardena, A., Booker, C., Pratt, J., Kellum, J. M. (1991) Pathways of serotonin-induced electrolyte transport in rat distal colon. Surgery 110: 411-418
47. Zimmerman, T. W., Binder, H. J. (1984) Serotonin-induced alteration of colonic electrolyte transport in the rat. Gastroenterology 86: 310-317