Stereoselective sulphate conjugation of fenoterol by human phenolsulphotransferases

Xenobiotica

Volumn 27, Issue 11, 1997, Pages 1147-1154

  Wilson, A A ^a   Wang, J ^c   Koch, P ^b   Walle, T ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b SUNOVION PHARMACEUTICALS INC   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

FENOTEROL; ISOENZYME; RECOMBINANT ENZYME; SULFOTRANSFERASE;

ARTICLE; CELL CULTURE; CELL STRAIN HEPG2; CONTROLLED STUDY; DRUG CONJUGATION; DRUG METABOLISM; ENZYME ACTIVITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; MASS SPECTROMETRY; STEREOCHEMISTRY;

BRONCHODILATOR AGENTS; CARCINOMA, HEPATOCELLULAR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FENOTEROL; HUMANS; ISOENZYMES; LIVER NEOPLASMS; RECOMBINANT PROTEINS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; STEREOISOMERISM; SUBSTRATE SPECIFICITY; SULFATES; SULFOTRANSFERASES; SULFUR RADIOISOTOPES; TOCOLYTIC AGENTS; TUMOR CELLS, CULTURED;

EID: 0030668373     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/004982597239903     Document Type: Article

References (16)

1. ANDERSON, R. J. and WEINSHILBOUM, R. M., 1980, Phenolsulphotransferase in human tissue : radiochemical enzymatic assay and biochemical properties. Clinica Chimica Acta, 103, 79-90.
2. BRASHEAR, W. T., KUHNERT, B. R. and WEI, R., 1990, Structural determination of the conjugated metabolites of ritodrine. Drug Metabolism and Disposition, 18, 488-493.
3. FALANY, C. N., WHEELER, J., OH, T. S. and FALANY, J. L., 1994, Steroid sulfation by expressed human cytosolic sulfotransferases. Journal of Steroid Biochemistry and Molecular Biology, 48, 369-375.
4. FOLDES, A. and MEEK, J. L., 1973, Rat brain phenolsulfotransferase - partial purification and some properties. Biochimica et Biophysica Acta, 327, 365-374.
5. GANGULY, T. C., KRASNYKH, V. and FALANY, C. N., 1995, Bacterial expression and kinetic characterization of the human monoamine-sulfating form of phenol sulfotransferase. Drug Metabolism and Disposition, 23, 945-950.
6. 2-receptor agonists by the human intestine and the recombinant M-form phenolsulfotransferase. Chirality (submitted).
7. HILDEBRANDT, R., WAGNER, B., PREISS-NOWZOHOUR, K. and GUNDERT-REMY, U., 1994, Fenoterol metabolism in man : sulphation versus glucuronidation. Xenobiotica, 24, 71-77.
8. LEWIS, A. J., KELLY, M. M., WALLE, U. K., EATON, E. A., FALANY, C. N. and WALLE, T., 1996, Improved bacterial expression of the human P form phenolsulfotransferase : applications to drug metabolism. Drug Metabolism and Disposition, 24, 1180-1185.
9. MORGAN, D. J., 1990, Clinical pharmacokinetics of β-agonists. Clinical Pharmacokinetics, 18, 270-294.
10. PESOLA, G. R. and WALLE, T., 1993, Stereoselective sulfate conjugation of isoproterenol in humans : comparison of hepatic, intestinal, and platelet activity. Chirality 5, 602-609.
11. WALLE, T. and WALLE, U. K., 1990, Stereoselective sulphate conjugation of racemic terbutaline by human liver cytosol. British Journal of Clinical Pharmacology, 30, 127-133.
12. WALLE, T., WALLE, U. K., SHWED, J. A., THORNBURG, K. R., MATHIS, C. E. and PESOLA, G. R., 1994, Human phenolsulfotransferases : chiral substrates and expression in Hep G2 cells. Chemico-Biological Interactions, 92, 47-55.
13. WALLE, T., WALLE, U. K., THORNBURG, K. R. and SCHEY, K. L., 1993a, Stereoselective sulfation of albuterol in humans : biosynthesis of the sulfate conjugate by Hep G2 cells. Drug Metabolism and Disposition, 21, 76-80.
14. WALLE, U. K., PESOLA, G. R. and WALLE, T., 1993b, Stereoselective sulphate conjugation of salbutamol in humans : comparison of hepatic, intestinal and platelet activity. British Journal of Clinical Pharmacology, 35, 413-418.
15. WEINSHILBOUM, R. and AKSOY, I., 1994, Sulfation pharmacogenetics in humans. Chemico-Biological Interactions, 92, 233-246.
16. WEINSHILBOUM, R. M., OTTERNESS, D. M., AKSOY, J. A., WOOD, T. C., HER, C. and RAFTOGIANIS, R. B., 1997, Sulfotransferase molecular biology : cDNAs and genes. FASEB Journal, 11, 3-14.