Total synthesis of B-chain of human α2HS glycoprotein

Tetrahedron Letters

Volumn 38, Issue 41, 1997, Pages 7211-7214

  Nakahara, Yoshiaki ^a,b   Nakahara, Yuko ^a   Ito, Yukishige ^a   Ogawa, Tomoya ^a,c  

^a INST OF PHYS AND CHEMICAL RESEARCH   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOPROTEIN;

ALPHA CHAIN; ARTICLE; DRUG SYNTHESIS; IN VITRO STUDY; MASS SPECTROMETRY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REACTION ANALYSIS;

EID: 0030667917     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01718-8     Document Type: Article

References (16)

1. For reviews see: Meldal, M.; Bock, K. Glycoconjugate J. 1994, 11, 59-63; Meldal, M. In Neoglycoconjugates, Lee, Y. C.; Lee, R. T., Ed.; Academic Press Inc: San Diego, 1994; pp 145-198; Norberg, T.; Lünig, B.; Tejbrant, J. Methods Enzymol., 1994, 247, 87-106.
2. For reviews see: Meldal, M.; Bock, K. Glycoconjugate J. 1994, 11, 59-63; Meldal, M. In Neoglycoconjugates, Lee, Y. C.; Lee, R. T., Ed.; Academic Press Inc: San Diego, 1994; pp 145-198; Norberg, T.; Lünig, B.; Tejbrant, J. Methods Enzymol., 1994, 247, 87-106.
3. For reviews see: Meldal, M.; Bock, K. Glycoconjugate J. 1994, 11, 59-63; Meldal, M. In Neoglycoconjugates, Lee, Y. C.; Lee, R. T., Ed.; Academic Press Inc: San Diego, 1994; pp 145-198; Norberg, T.; Lünig, B.; Tejbrant, J. Methods Enzymol., 1994, 247, 87-106.
4. Hietter, H.; Schultz, M.; Kunz, H. SYNLETT 1995, 1219-1220; Jansson, A. M.; Jensen, K. J.; Meldal, M.; Lomako, J.; Lomako, W. M.; Olsen, C. E.; Bock, K. J. Chem. Soc., Perkin Trans. 1 1996, 1001-1006; Liebe, B.; Kunz, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 618-621.
5. Hietter, H.; Schultz, M.; Kunz, H. SYNLETT 1995, 1219-1220; Jansson, A. M.; Jensen, K. J.; Meldal, M.; Lomako, J.; Lomako, W. M.; Olsen, C. E.; Bock, K. J. Chem. Soc., Perkin Trans. 1 1996, 1001-1006; Liebe, B.; Kunz, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 618-621.
6. Hietter, H.; Schultz, M.; Kunz, H. SYNLETT 1995, 1219-1220; Jansson, A. M.; Jensen, K. J.; Meldal, M.; Lomako, J.; Lomako, W. M.; Olsen, C. E.; Bock, K. J. Chem. Soc., Perkin Trans. 1 1996, 1001-1006; Liebe, B.; Kunz, H. Angew. Chem. Int. Ed. Engl. 1997, 36, 618-621.
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9. Gejyo, F.; Schmid, K. Biochim. Biophys. Acta 1981, 671, 78-84 and references cited therein.
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13. 2O, 25 °C (or 60 °C), t-BuOH (δ 1.23)]: δ 7.62 (brs, 1 H, His), 7.31 (brt, 2 H, Phe), 7.27 (bit, 1 H, Phe), 7.19 (d, 2 H, J 7.3 Hz, Phe), 6.85 (brs, 1 H, His), 4.89 (d, 1 H, J 2.4 Hz, H-1:GalNAc, 60 °C), 4.45 (d, 1 H, J 7.3 Hz, H-1:Gal), 4.19 (brd, 1 H, J 2.4 Hz, H-4:GalNAc), 3.51 (brt, 1 H, H-2:Gal), 2.74 (dd, 1 H, J 4.3, 12.2 Hz, H-3eq:NeuAc), 2.02 and 1.99 (2s, 6 H, 2Ac:GalNAc and NeuAc), 1.77 (t, 1 H, J 12.2 Hz, H-3ax: NeuAc).
14. Nakahara, Y.; Iijima, H.; Ogawa, T. Carbohydr. Lett. 1994, 1, 99-106.
15. Ciommer, M.; Kunz, H. SYNLETT 1991, 593-595.
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