Inhibition of rat renal and testicular 11 β-hydroxysteroid dehydrogenase by some antihypertensive drugs, diuretics, and epitestosterone

Hormone and Metabolic Research

Volumn 29, Issue 9, 1997, Pages 465-468

  Bicikova M ^a   Hill, M ^a   Hampl, R ^a   Starka L ^a  

^a INSTITUTE OF ENDOCRINOLOGY   (Czech Republic)

Author keywords

11 Hydroxyandrostenedione; Corticosterone; Enzyme; Glucocorticoid; Mineralocorticoid

Indexed keywords

11BETA HYDROXYANDROSTENEDIONE; 11BETA HYDROXYSTEROID DEHYDROGENASE; ANTIHYPERTENSIVE AGENT; BENAZEPRIL; BETAXOLOL; BISOPROLOL; CAPTOPRIL; CORTICOSTERONE; DIHYDRALAZINE; DIURETIC AGENT; ENALAPRIL; ENDRALAZINE; EPITESTOSTERONE; FUROSEMIDE; GLYCYRRHETINIC ACID; METHYLDOPA; METIPAMIDE; METOPROLOL; MINOXIDIL; PRAZOSIN; QUINAPRIL; TRANDOLAPRIL; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; IN VITRO STUDY; KIDNEY; NONHUMAN; PRIORITY JOURNAL; RAT; TESTIS;

ANIMALIA;

EID: 0030667247     PISSN: 00185043     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-979079     Document Type: Article

References (15)

1. White, P. C., L. Pascoe, K. M. Curnow, C. Tannin, A. Rösler: Molecular biology of 11β-hydroxylase and 11β-hydroxysteroid dehydrogenase enzymes. J Steroid Biochem Molec Biol 43: 827-835 (1992)
2. Phillips, D. M., V. Lakshmi, C. Monder: Corticosteroid 11β-dehydrogenase in rat testis. Endocrinology 125: 209-216 (1989)
3. Whorwood, C. B., J. A. Fraklyn, M. C. Sheppard, P. M. Stewart: Tissue localization of 11β-hydroxysteroid dehydrogenase and its relationship to the glucocorticoid receptor. J. Steroid Biochem Molec Biol 41: 21-28 (1992)
4. Monder, C., M. P. Hardy, R. J. Blanchard, D. C. Blanchard: Comparative aspects of 11β-hydroxysteroid dehydrogenase. Testicular 11β-HSD dehydrogenase: Development of a model for the mediation of Leydig cell function by corticosteroids. Steroids 59: 69-73 (1994)
5. Escher, G., K. V. Meyer, B. S. Vishwanath, B. M. Frey, F.J. Frey: Furosemide inhibits 11β-hydroxysteroid dehydrogenase in vitro and in vivo. Endocrinology 136, 4: 1759-1765 (1995)
6. Holownia, P., E. J. Owen, C. S. Conway J. Round, J. W. Honour: Studies to confirm the source of 11β-hydroxy-androstenedione. J Steroid Biochem Molec Biol 4: 875-880 (1992)
7. 21-steroid side chain cleavage int he testis. J Steroid Biochem Molec Biol 43: 721-724 (1992)
8. Stárka, L., M. Bicíková, R. Hampl: Epitestosterone - an endogenous antiandrogen? J Steroid Biochem 33: 1019-1021 (1989)
9. Menini, E., J. K. Norymberski: An approach to the systemic analysis of urinary steroids. Biochem J 95: 1-16 (1965)
10. Lakshmi, V., C. Monder: Evidence for independent 11-oxidase and 11-reductase activities of 11β-hydroxysteroid dehydrogenase: enzyme latency, phase transitions, and lipid requirement. Endocrinol 116: 552-560 (1985)
11. Marandici, A., C. Monder: Inhibition by glycyrrhetinic acid of rat tissue 11β-hydroxysteroid dehydrogenase. Steroids 58: 153-156 (1993).
12. Putz, Z., R. Hampl, J. Velemínsky, A. Kreze, J. Šulcová, L. Stárka: Radioimmunoassay of 11β-hydroxyandrostenedione in laboratory diagnostics of selected endocrine disorders. J Clin Biochem 25: 723-728 (1987)
13. Bélanger, B., J: Fiet, A. Bélanger: Effects of adrenocorticotropin on adrenal and plasma 11β-hydroxyandrostene-dione in the guinea pig and determination of its relative androgen potency. Steroids 58: 29-34 (1993)
14. Goldzieher, J. W., A. De la Pena, M. M. Aivaliotis: Radioimmunoassay of plasma androstenedione, testosterone, and 11β-hydroxyandrostenedione after chromatography on Lipidex-5000 (Hydroxyalkopropyl Sephadex). J Steroid Biochem 9: 169-173 (1978)
15. Monder, C.: Corticosteroids, receptors, and the organic-specific functions of 11β-hydroxysteroid dehydrogenase. FASEB J 5: 3047-3054 (1991)