A phase I/II study of paclitaxel (TAXOL®) and concurrent radiotherapy in advanced nonsmall cell lung cancer

International Journal of Radiation Oncology Biology Physics

Volumn 39, Issue 5, 1997, Pages 1107-1111

  Kirkbride, Peter ^a,e   Gelmon, Karen ^b   Eisenhauer, Elizabeth ^c   Fisher, Bryn ^c   Dulude, Hélène ^d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c QUEEN S UNIVERSITY   (Canada)

^d Bristol Myers Squibb Canada   (Canada)

^e Princess Margaret Cancer Centre   (Canada)

Author keywords

Lung carcinoma; Paclitaxel; Radical radiotherapy; Radiosensitiser

Indexed keywords

PACLITAXEL; PLATINUM DERIVATIVE; RADIOSENSITIZING AGENT;

ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER SURVIVAL; CLINICAL ARTICLE; CLINICAL TRIAL; DRUG EFFICACY; ESOPHAGITIS; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LETHARGY; LUNG NON SMALL CELL CANCER; LYMPHOCYTOPENIA; MALE; MAXIMUM ALLOWABLE CONCENTRATION; NEUTROPENIA; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIZATION; SKIN TOXICITY; THROMBOCYTOPENIA;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CARCINOMA, NON-SMALL-CELL LUNG; COMBINED MODALITY THERAPY; DRUG ADMINISTRATION SCHEDULE; HUMANS; LUNG NEOPLASMS; LYMPHOPENIA; PACLITAXEL;

EID: 0030667176     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(97)00548-8     Document Type: Article

References (13)

1. Alberola, V.; Rosell, R.; Gonzalez, L. J.; et al. Single agent Taxol, 3-hour infusion, in untreated advanced non-small-cell lung cancer. Ann. Oncol. 6 (Suppl. 3):S49-S52; 1995.
2. American Cancer Society. Cancer facts and figures 1996.
3. Antonia, S. J.; Wagner, H.; Williams, C.; et al. Concurrent paclitaxel/cisplatin with thoracic radiation in patients with stage IIIA/B non-small cell carcinoma of the lung. Semin. Oncol. 22(Suppl. 9):34-37; 1995.
4. Chang, A.; Kim, K.; Glick, J.; et al. Phase II study of paclitaxel, piroxantrone and merbarone in patients with stage IV non small cell lung cancer. J. Natl. Cancer Inst. 85:388-394; 1993.
5. Choy, H.; Akerley, W.; Safran, H.; et al. Phase I trial of outpatient weekly paclitaxel and concurrent radiation therapy for advanced non-small cell lung cancer. J. Clin. Oncol. 12: 2682-2628; 1994.
6. Hellman, S.; Kligerman, M. M.; VonEssen, C. P.; et al. Sequalae of radical radiotherapy to the lung. Radiology 82: 1055; 1964.
7. Millward, M. J.; Bishop, J. F.; Friedlander, M.; et al. Phase II trial of a 3-hour-infusion of paclitaxel in previously untreated patients with advanced non-small cell lung cancer. J. Clin. Oncol. 14:142-148; 1996.
8. Murphy, W.; Fossella, F. V.; Winn, R. J.; et al. A phase II study of paclitaxel in patients with untreated non small cell lung cancer. J. Natl. Cancer Inst. 85:384-388; 1993.
9. Nonsmall cell Lung Cancer Study group. Chemotherapy in non-small cell lung cancer: A meta-analysis using updated individual patient data from 52 randomised clinical trials. Br. Med. J. 311:899-909; 1995.
10. Reckzeh, B.; Merte, M.; Pluger, K.-H.; et al. Severe lymphocytopenia and interstitial pneumonia in patients treated with paclitaxel and simultaneous radiotherapy for non-small cell lung cancer. J. Clin. Oncol. 14:1071-1076; 1996.
11. Rosell, R.; Gonzalez, L. J.; Alberola, V.; et al. Single-agent paclitaxel by 3-hour infusion in the treatment of non-small cell lung cancer: links between p53 and K-ras gene status and chemosensitivity. Semin. Oncol. 22(Suppl. 14):12-18; 1995.
12. Schiff, P.; Fant, J.; Horowitz, S. B. Promotion of microtubule assembly in vitro by taxol. Nature 277:665-667; 1979.
13. Tishler, R. B.; Schiff, P. B. Geard, C. R.; Hall, E. J. Taxol: A novel radiation sensitiser. Int. J. Radiat. Oncol. Biol. Phys. 22:613-617; 1992.