The influence of the C1-inhibitor BERINERT® and the protein-free haemodialysate ACTIHAEMYL20%® on the evolution of the depth of scald burns in a porcine model

Burns

Volumn 23, Issue 6, 1997, Pages 473-477

  Henze, U ^a   Lennartz, A ^a   Hafemann, B ^a   Goldmann, C ^a   Kirkpatrick, C J ^b   Klosterhalfen, B ^a,c  

^a RWTH AACHEN UNIVERSITY   (Germany)

^b JOHANNES GUTENBERG UNIVERSITY   (Germany)

^c UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

C1 inhibitor; Haemodialysate; Pig; Scald burn

Indexed keywords

ACTIHAEMYL; BERINERT; COMPLEMENT COMPONENT C1S INHIBITOR; HEMODIALYSIS FLUID; HOT WATER; LACTIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BURN; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FLUID THERAPY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MICROCIRCULATION; NONHUMAN; SCALD; SKIN BIOPSY; SKIN BLOOD FLOW; SWINE; THERMAL INJURY;

EID: 0030666428     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0305-4179(97)00019-3     Document Type: Article

References (32)

1. Ninnemann JL. Trauma, sepsis and the immune response. J Burn Care Rehab 1987; 8: 462-468.
2. Rossano C, Weiner M, Haigis E. Clinical, blood gas, and lactate changes in the course of the treatment of peripheral vascular disease with a hemodialysate. Arzneimittel-Forsch/ Drug Res 1990; 40: 1195-1200.
3. Schreier T, Deger E, Baschong W. Fibroblast migration and proliferation during in vitro wound healing. A quantitative comparison between various growth factors and a low molecular weight blood dialysate used in the clinic to normalize impaired wound healing. Res Expl Med 1993; 193: 195-205.
4. Miltenburger HG, Baschong W. Cooperative effect in vitro on fibroblast and keratinocyte functions related to wound healing by transforming growth factor-β and a low molecular weight fraction from hemolyzed blood. Arzneimittel-Forsch/Drug Res 1994; 44: 872-876.
5. Isler H, Bauen A, Baschong W. Topical treatment of standardized burns with a protein-free haemodialysate. Burns 1991; 17: 93-97.
6. Isler H, Bauen A, Hubler M, Oberholzer M. Morphometric assessment of wound healing in rats with a protein-free haemodialysate. Burns 1991; 17: 99-103.
7. Hettich R. Interactions between local and generalized burn edema. Resuscitation 1986; 14: 105-112.
8. Kuninaka T, Senga Y, Senga H, Weiner M. Nature of enhanced mitochondrial oxidative metabolism by a calf blood extract. J Cell Physiol 1991; 146: 148-155.
9. Spessotto P, Dri P, Baschong W. Effect of a protein-free dialysate from calf blood on human monocyte differentiation in vitro. Arzneimittel-Forsch/Drug Res 1993; 43: 747-751.
10. Fabbro D, Imber R, Huggel K, Baschong W. Growth-promoting effect of a protein-free hemodialysate used in situation of hypoxia and for tissue repair as measured via stimulation of S6-kinase. Arzneimittel-Forsch/Drug Res 1992; 42: 917-920.
11. Nürnberger W, Göbel U, Stannigel H, Eisele B, Janssen A, Delvos U. C1-Inhibitor concentrate for sepsis-related capillary leak syndrome. Lancet 1992; 339: 990.
12. Eisele B, Delvos U. From localized angioedema to generalized capillary leak syndrome: evidence for a pivotal role of C1-inhibitor in septic shock-like syndrome. Intens Care Emerg Med 1994; 18: 501-527.
13. Kirschfink M. Pharmakologische Beeinflussung des Komplementsystems. Dtsch Med Wschr 1995; 120: 1087-1090.
14. Hack CE, Ogilivie AG, Eisele B, Ferenberg AJ, Wagstaff J, Thijs LG. C1-Inhibitor substitution therapy in septic shock and in the vascular leak syndrome induced by high doses of interleukin-2. Intens Care Med 1993; 19(Suppl 1): 19-28.
15. Converse JM, Platt JM, Ballantyne DL. An experimental evaluation of a histochemical diagnosis of burn depth. J Surg Res 1965; 5: 547-551.
16. Behounkova-Houskova E, Moserova J. Histology of healing of deep dermal burns in pigs. Scand J Plast Reconstr Surg 1979; 13: 57-60.
17. Lazare R, Watson PA, Winter GD. Distribution and excretion of silver sulphadiazine applied to scalds in the pig. Burns 1974; 1: 57-64.
18. Winter GD. Formation of the scar and the rate of epithelialization of superficial wounds in the skin of the young domestic pig. Nature 1962; 193: 293-294.
19. Winter GD. Histological aspects of burn wound healing. Burns 1974; 1: 191-196.
20. Bustad LK. Use of pigs in biomedical research. Nature 1965; 208: 531.
21. Douglas WR. Of pigs and men research: a review of applications and analogies of the pig Sus scofa, in human medical research. Space Life Sci 1972; 3: 226-232.
22. Meyer W, Schwarz R, Neurand K. The skin of domestic mammals as a model for the human skin with special reference to the domestic pig. Curr Probl Dermatol 1978; 7: 39-52.
23. Brans TA, Dutrieux RP, Hoeckstra MJ, Kreis RW, Du Pont JS. Histopathological evaluation of scalds and contact burns in the pig model. Burns 1994; 20: 48-51.
24. Forbes PD. Vascular supply of the skin and hair in swine. In: Montagna W and Dobson RL (eds) Hair growth-advances in biology of skin. Oxford: Pergamom; 1967: p 419.
25. Ingram DL, Weaver ME. A quantitative study of the blood vessels of the pig's skin and the influence of environmental temperature. Anat Res 1969; 163: 517-524.
26. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Meth 1983; 65: 55-63.
27. Van der Graaf F, Koedam JA, Bouna BN. Inactivation of kallikrein in human plasma. J Clin Invest 1983; 71: 149-158.
28. Hugli TE. Complement anaphylatoxins as plasma mediators, spasmogens and chemotaxins. In: Bing DH (ed) The chemistry and physiology of human plasma proteins. New York: Pergamon Press; 1979: pp 255-280.
29. Adam A, Damas J, Albert A, Ers P, Marichi J, Calay G, Laurent P. Plasma prokallikrein and kininogens in burned patients. Thromb Res 1986; 41: 537-543.
30. Sacks T, Moldow CF, Craddock PR, Bowers TK, Jacob HS. Oxygen radicals mediate endothelial cell damage by complement-stimulated granulocytes. An in vitro model of immune vascular damage. J Clin Invest 1978; 61: 1161-1167.
31. Smedly LA, Tonnesen MG, Sandhaus RA, Haslett C, Guthrie LA, Johnston RB, Henson PM, Worthen GS. Neutrophil-mediated injury to endothelial cells: enhancement by endotoxin and essential role of neutrophil elastase. J Clin Invest 1986; 77: 1233-1243.
32. Shakespeare PG. Looking at burn wounds: The A.B. Wallace Memorial Lecture 1991. Burns 1992; 18: 287-295.