Brown adipose tissue and its uncoupling protein in chronically hypoxic rats

Clinical Science

Volumn 93, Issue 4, 1997, Pages 349-354

  Mortola, Jacopo P ^a   Naso, Lina ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Hypoxia; Non shivering thermogenesis; Thermoregulation

Indexed keywords

ACTIN; CELL PROTEIN; PROTEIN; THERMOGENIN; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY MASS; BROWN ADIPOSE TISSUE; CONTROLLED STUDY; DNA CONTENT; ELECTROPHORESIS; ENVIRONMENTAL TEMPERATURE; HEMATOCRIT; HYPOXIA; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; THERMOGENESIS;

EID: 0030666413     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0930349     Document Type: Article

References (31)

1. Mortola JP, Gautier H. Interaction between metabolism and ventilation: effects of respiratory gases and temperature. In: Dempsey JA, Pack AI, eds. Regulation of breathing. 2nd ed. New York: Marcel Dekker Inc., 1995, chapter 23, 1011-64.
2. Bukowiecki L, Collet AJ, Follea N, Guay G, Jahjah L. Brown adipose tissue hyperplasia: a fundamental mechanism of adaptation to cold and hyperphagia. Am J Physiol 1982; 242 (Endocrinol Metab 5): E353-9.
3. Mory G, Ricquier D, Nechad M, Hemon P. Impairment of trophic response of brown fat to cold in guanethidine-treated rats. Am J Physiol 1982; 242 (Cell Physiol. 11): C159-65.
4. Nedergaard J, Lindberg O. The brown fat cell. Int Rev Cytol 1982; 74: 187-286.
5. Janský L. Non-shivering thermogenesis and its thermoregulatory significance. Biol Rev 1973; 48: 85-132.
6. Smith RE, Horwitz BA. Brown fat and thermogenesis. Physiol Rev 1969; 49: 330-424.
7. Nedergaard J, Cannon B. The uncoupling protein thermogenin and mitochondrial thermogenesis. In: Ernster L, ed. Molecular mechanisms in bioenergetics. Amsterdam: Elsevier Science, 1992, chapter 17: 385-420.
8. Bukowiecki LJ, Géloën A, Collet AJ. Proliferation and differentiation of brown adipocytes from interstitial cells during cold acclimation. Am J Physiol 1986; 250 (Cell Physiol 19): C880-7.
9. Géloën A, Collet AJ, Guay G, Bukowiecki LJ. β-Adrenergic stimulation of brown adipocyte proliferation. Am J Physiol 1988; 254 (Cell Physiol 23): C175-82.
10. Morroni M, Barbatelli G, Zingaretti MC, Cinti S. Immunohistochemical, ultrastructural and morphometric evidence for brown adipose tissue recruitment due to cold acclimation in old rats. Int J Obes 1995; 19: 126-31.
11. Cannon B, Nedergaard J. Biochemical aspects of acclimation to cold. J Therm Biol 1983; 8: 85-90.
12. Gleed RD, Mortola JP. Ventilation in newborn rats after gestation at simulated high altitude. J Appl Physiol 1991; 70: 1146-51.
13. Schneider WC. Determination of nucleic acids by pentose analysis. Methods Enzymol 1957; 3: 680-4.
14. Mortola JP, Morgan CA, Virgona V. Respiratory adaptation to chronic hypoxia in newborn rats. J Appl Physiol 1986; 61: 1329-36.
15. Piazza T, Lauzon AM, Mortola JP. Time course of adaptation to hypoxia in newborn rats. Can J Physiol Pharmacol 1988; 66: 152-8.
16. Mortola JP, Matsuoka T, Saiki C, Naso L. Metabolism and ventilation in hypoxic rats: effect of body mass. Respir Physiol 1994; 97: 225-34.
17. Saiki C, Matsuoka T, Mortola JP. Metabolic-ventilatory interaction in conscious rats: effect of hypoxia and ambient temperature. J Appl Physiol 1994; 76: 1594-9.
18. Skála J, Hahn P. Changes in interscapular brown adipose tissue of the rat during perinatal and early postnatal development after cold acclimation. VI. Effect of hormones and ambient temperature. Int J Biochem 1974; 5: 95-106.
19. Jacobsson A, Stadler U, Glotzer MA, Kozak LP. Mitochondrial uncoupling protein from mouse brown fat. Molecular cloning, genetic mapping and mRNA expression. J Biol Chem 1985; 260: 16250-4.
20. Rehnmark S, Néchad M, Herron D, Cannon B, Nedergaard J. α- and β-Adrenergic induction of the expression of the uncoupling protein thermogenin in brown adipocytes differentiated in culture. J Biol Chem 1990; 265: 16464-71.
21. Ricquier D, Bouillaud F, Toumelin P. et al. Expression of uncoupling protein mRNA in thermogenic or weakly thermogenic brown adipose tissue. Evidence for a rapid β-adrenoreceptor-mediated and transcriptionally regulated step during activation of thermogenesis. J Biol Chem 1986; 261: 13905-10.
22. Ricquier D, Mory G, Bouillaud F, Thibault J, Weissenbach J. Rapid increase in mitocondrial uncoupling protein and its mRNA in stimulated brown adipose tissue. Use of a cDNA probe. FEBS Lett 1984; 178: 240-4.
23. Ogawa K, Ohno T, Yahata T, Kuroshima A. Effect of hypoxia on brown adipose tissue (BAT)- with special reference to fatty acids (FA) compositions [Abstract]. Jpn J Physiol 1993; 43 (Suppl. 2): S311.
24. Park IRA, Himms-Hagen J. Neural influences on trophic changes in brown adipose tissue during cold acclimation. Am J Physiol 1988; 255 (Regul Integr Comp Physiol 24): R874-81.
25. Kurosawa M. Reflux changes in thermogenesis in the interscapular brown acipose tissue in response to thermal stimulation of the skin via sympathetic efferent nerves in anesthetized rats. J Auton Nerv Syst 1991; 33: 15-24.
26. Tamaki Y, Nakayama T. Effects of air constituents on thermosensitivities of preoptic neurons: hypoxia versus hypercapnia. Pflügers Arch 1987; 409: 1-6.
27. Nicholls DG. Hamster brown-adipose-tissue mitochondria. The control of respiration and the proton electrochemical potential gradient by possible physiological effectors of the proton conductance of the inner membrane. Eur J Biochem 1974; 49: 573-83.
28. Bertin R, De Marco F, Mouroux I, Portet R. Postnatal development of nonshivering thermogenesis in rats: effects of rearing temperature. J Dev Physiol 1993; 19: 9-15.
29. Barnard T, Skála J. The development of brown adipose tissue. In: Lindberg O, ed. Brown adipose tissue. New York: Elsevier, 1970, chapter 2, 33-72.
30. Desautels M, Dulos RA, Mozaffari B. Selective loss of uncoupling protein from mitochondria of surgically denervated brown adipose tissue of cold-acclimated mice. Biochem Cell Biol 1986; 64: 1125-34.
31. Puigserver P, Herron D, Gianotti M, Palou A, Cannon B, Nedergaard J. Induction and degradation of the uncoupling protein thermogenin in brown adipocytes in vitro and in vivo. Biochem J 1992; 284: 393-8.