Trophic effects of melanotropin-potentiating factor (MPF) on cultures of cells of the central nervous system

Peptides

Volumn 18, Issue 7, 1997, Pages 1015-1021

  Owen, D B ^a   Morley, J S ^b   Ensor, D M ^a   Allen, Y S ^a   Miles, J B ^b  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

^b Fazakerley   (United Kingdom)

Author keywords

Astrocytes; Melanotropin potentiating factor (MPF); Neurons; Neurotrophic effects; NGF

Indexed keywords

BETA LIPOTROPIN; INTERMEDIN; NERVE GROWTH FACTOR; TETRAPEPTIDE;

ANIMAL CELL; ARTICLE; ASTROCYTE; CELL CULTURE; CELL PROLIFERATION; CHOLINERGIC NERVE CELL; DOPAMINERGIC NERVE CELL; DOSE RESPONSE; FETUS; NERVE FIBER GROWTH; NEUROTROPISM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT;

ADRENOCORTICOTROPIC HORMONE; ANIMALS; ASTROCYTES; CELL DIVISION; CELLS, CULTURED; CENTRAL NERVOUS SYSTEM; CEREBRAL CORTEX; CYTARABINE; DOPAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDORPHINS; HUMANS; MESENCEPHALON; MODELS, NEUROLOGICAL; NERVE GROWTH FACTORS; NEURONS; PEPTIDE FRAGMENTS; RATS;

ANIMALIA;

EID: 0030665712     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(97)00043-0     Document Type: Article

References (13)

1. Antonawich F. J., Azmita E. C., Strand F. L. Rapid neurotrophic actions of an ACTH/MSH (4-9) analogue after nigrostriatal 6-OHDA lesioning. Peptides. 14:1993;1317-1993.
2. Bazzaz, A. A.; Morley, J. S.; Miles, J. B. Neurotrophic peptide (MPF analogue) restores nigral dopaminergic neurons in a rat model of Parkinson's disease. J. Pathol. (submitted).
3. Carter R. J., Shuster S., Morley J. S. Melanotropin is the C-terminal tetrapeptide of human β-lipotropin. Nature. 279:1979;74.
4. Ensor D. M., Morley J. S., Redfern R. M., Miles J. B. Stimulation of dopamine output from adrenal medullary cells by β-endorphin and its C-terminal tetrapeptide (MPF). Brain Res. 490:1989;196-199.
5. Ensor D. M., Morley J. S., Redfern R. M., Miles J. B. The activity of an analogue of MPF (β-endorphin 28-31) in a rat model of Parkinson's disease. Brain Res. 610:1993;166-168.
6. Gispen W. H., et al. On the neurotrophic action of melanocortins. Prog. Brain Res. 72:1987;319-331.
7. Lewis J. R. E., Morley J. S., Venn R. F. Analysis of β-endorphin 28-31 (melanotropin potentiating factor) and analogues by high-performance liquid chromatography of their 9-fluorenylmethoxycsarbonyl derivatives. J. Chromatogr. 615:1993;37-45.
8. Morley, J. S. The design of antagonists to gastrin. In: Miyoshi, A., Ed. Gut peptides and ulcer. Tokyo; Biomed. Res. Found.; 1983:1-14.
9. Morley J. S., Bazzaz A. A., Ensor D. M., Miles J. B. Reversal of mitochondrial damage in a rat model of Parkinson's disease by a neurotrophic peptide (MPF analogue). Neuroreport. 5:1994;1877-1881.
10. Morley J. S., Ensor D. S. Neurotrophic effects of β-endorphin C-terminal tetrapeptide (MPF). Neuropeptides. 8:1986;45-49.
11. Morley J. S., Hayward C. F., Carter R. J., Shuster S. MPF analogue with stability to proteolysis. Neuropeptides. 2:1981;109-114.
12. Strand F. L., Rose K. J., Zuccarelli L. A., Kume J., Alves S. E., Antonawich F. J., Garrett L. A. Neuropeptide hormones as neurotrophic factors. Physiol. Rev. 71:1991;1017-1046.
13. Van Der Neut R., Bar P. R., Sodaar P., Gispen W. H. Trophic influences of alpha-MSH and ACTH 4-10 on neuronal outgrowth in vitro. Peptides. 9:1988;1015-1020.