Nitecapone is of benefit to functional performance in experimental heart transplantation

Research in Experimental Medicine

Volumn 197, Issue 3, 1997, Pages 137-146

  Vento, A E ^a   Ramo O J ^a   Nemlander, A T ^a   Nissinen, E ^b   Holopainen, A ^b   Mattila, S P ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b ORION CORPORATION   (Finland)

Author keywords

Antioxidant; Functional recovery; Heart transplantation; Injury; Ischemia reperfusion; Rat

Indexed keywords

ANTIOXIDANT; NEW DRUG; NITECAPONE; OXYGEN RADICAL; RINGER SOLUTION;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA GRAFT; ARTERY CLAMP; ARTICLE; CHEMOLUMINESCENCE; CONTROLLED STUDY; END TO SIDE ANASTOMOSIS; GRAFT SURVIVAL; HEART ARRHYTHMIA; HEART BEAT; HEART LEFT VENTRICLE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PRESERVATION; HEART RIGHT VENTRICLE; HEART TRANSPLANTATION; HEART VENTRICLE SEPTUM; INFERIOR CAVA VEIN; ISCHEMIA; LIPID PEROXIDATION; NONHUMAN; ORGAN DONOR; PRIORITY JOURNAL; PULMONARY ARTERY; RAT; REPERFUSION INJURY; TEMPERATURE; TIME; TISSUE SECTION;

ANIMALS; ANTIOXIDANTS; CATECHOLS; CHEMILUMINESCENT MEASUREMENTS; FEMALE; HEART TRANSPLANTATION; MALE; MYOCARDIAL REPERFUSION INJURY; PENTANONES; RATS; RATS, WISTAR; VENTRICULAR FUNCTION, LEFT;

EID: 0030664977     PISSN: 03009130     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004330050063     Document Type: Article

References (24)

1. Axford-Gatley RA, Wilson GJ (1991) Reduction of experimental myocardial infarct size by oral administration of alpha-tocopherol. Cardiovasc Res 25:89-92
2. Bellows SD, Hale SL, Simkhovich BZ, Kay GL, Klonen RA (1995) Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion? Cardiovasc Drugs Ther 9:117-123
3. Drossos G, Lazou A, Panagopoulos P, Westaby S (1995) Deferoxamine cardioplegia reduces superoxide radical production in human myocardium. Ann Thorac Surg 59:169-172
4. Doyle AR, Dhir AK, Moors AH, Latimer RD (1995) Treatment of perioperative low cardiac output syndrome. Ann Thorac Surg 59:3-11
5. Ferrari R (1995) Metabolic disturbances during myocardial ischemia and reperfusion. Am J Cardiol 76:17B-24B
6. Ferrari R (1990) The role of free radicals in ischemic myocardium. Br J Clin Pract 44:301-305
7. Ferrero M, Marni A, Parise M, Salari PC, Gaja G (1991) Protection of rat heart from damage due to ischemia-reperfusion during procurement and grafting by defibrotide. Transplantation 52:611-615
8. Haramaki N, Stewart DB, Aggarwal S, Kawabata T, Packer L (1995) Role of ascorbate in protection by nitecapone against cardiac ischemia-reperfusion injury. Biochem Pharmacol 50:839-843
9. van Jaarsveld H, Kuyl JM, Alberts DW, Wiid MN (1994) Antioxidant supplementation partially protects against myocardial mitochondrial ischemia/reperfusion injury, but ascorbate in the perfusate prevented the beneficial effect. Res Commun Mol Pathol Pharmacol 85:33-44
10. Klein HH, Pich S, Lindert S, Nebendahl K, Niedmann P, Kreuzer H (1989) Combined treatment with vitamin E and C in experimental myocardial infarction in pigs. Am Heart J 118:667-673
11. Marcocci L, Suzuki YJ, Tsuchiya M, Packer L (1994) Antioxidant activity of nitecapone and its analog OR-1246: effect of structure modification on antioxidant action. Methods Enzymol 234:528-541
12. Menasche P, Pascuier C, Bellucci S, Lorente P, Jaillon P, Piwnica A (1988) Deferoxamine reduces neutrophil-mediated free radical production during cardiopulmonary bypass in man. J Thorac Cardiovasc Surg 96:582-589
13. Menasche P, Piwnica A (1989) Free radicals and myocardial protection: a surgical viewpoint. Ann Thorac Surg 47:939-945
14. Morita K, Ihnken K, Buckberg GD, Sherman MP, Young HH (1995) Studies of hypoxemic/reoxygenation injury: without aortic clamping IV. Role of the iron-catalyzed pathway: deferoxamine. J Thorac Cardiovasc Surg 110:1190-1199
15. Ono K, Lindsey ES (1969) Improved technique of heart transplantation in rats. J Thorac Cardiovasc Surg 57:225-229
16. Oz MC, Pinsky DJ, Koga S, Liao H, Marboe CC, Han D, Kline R, Jeevanandam V, Williams M, Morales A, Popilskis S, Nowygrod R, Stern DM, Rose EA, Michler RE (1993) Novel preservation solution permits 24-hour preservation in rat and baboon cardiac transplant models. Circulation 88:291-297
17. Pentikäinen MO, Lindstedt KA, Kovanen PT (1995) Inhibition of the oxidative modification of LDL by nitecapone. Arterioscler Thromb Vasc Biol 15:740-747
18. Prasad K, Lee P, Mantha SV, Kalra J, Prasad M, Gupt, JB (1992) Detection of ischemia-reperfusion cardiac injury by cardiac muscle chemiluminescence. Mol Cell Biochem 115:49-58
19. Reilly PM, Schiller HJ, Bulkley GB (1991) Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites. Am J Surg 161: 488-503
20. Sebbag L, Forrat R, Canet E, Renaud S, Delaye J, de Lorgeril M (1994) Effects of dietary supplementation with alpha-tocopherol on myocardial infarct size and ventricular arrhythmias in a dog model of ischemia-reperfusion. J Am Coll Cardiol 24:1580-1585
21. Sisto T, Paajanen H, Metsä-Ketelä T, Harmoinen A, Nordback I, Tarkka M (1995) Pretreatment with antioxidants and allopurinol diminishes cardiac onset events in coronary artery bypass grafting. Ann Thorac Surg 59:1519-1523
22. Suzuki YJ, Tsuchiya M, Safadi A, Kagan VE, Packer L (1992) Antioxidant properties of nitecapone (OR-462). Free Radic Biol Med 13:517-525
23. Valenza M, Serbinova E, Packer L (1993) Nitecapone protects the Langerdorff-perfused heart against ischemia-reperfusion injury. Biochem Mol Biol Int 29:443-449
24. Zweier JL, Flaherty JT, Weisfeldt ML (1987) Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc Natl Acad Sci USA 84:1404-1408