Linomide enhances apoptosis in CD4+CD8 thymocytes

Scandinavian Journal of Immunology

Volumn 46, Issue 5, 1997, Pages 488-494

  Harring, A C ^a   Xu, Z ^a   Andersson, G ^a   Hedlund, G ^a  

^a Pharmacia & Upjohn AB   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; ROQUINIMEX;

ADRENALECTOMY; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; DOSE RESPONSE; DRUG EFFECT; FEMALE; GROWTH INHIBITION; IMMUNOMODULATION; LYMPHOCYTE DEPLETION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; THYMOCYTE;

EID: 0030664338     PISSN: 03009475     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-3083.1997.d01-155.x     Document Type: Article

References (17)

1. Kisielow P, Von Boehmer H. Development and seiection of T cells: Facts and Puzzles. Adv in Immunol 1995;58:87-209.
2. Boyd RL, Tucek CL, Godfrey DI et al. The thymic microenvironment. Immunol Today 1993;14:445-9.
3. Scollay R, Godfrey DI. Thymic emigration: conveyor belts or lucky dips? Immunol Today 1995;16:268-73.
4. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activity. Nature 1980;284:555-6.
5. Kalland T, Alm G, Stålhandske T. Augmentation of natural killer cell activity by LS 2616, a new immunomodulator. J Immunol 1985;134:3956-61.
6. Stålhandske T, Kalland T. Effects of the novel immunomodulator LS 2616 on the delayed-type hypersensitivity reaction to Bordetella pertussis in the rat. Immunopharmacology 1986;11:87-92.
7. Larsson E-L, Joki A, Stålhandske T. Mechanism of action of the new immunomodulator LS 2616 on T cell responses. Int J Immunopharm 1987;9:425-31.
8. Spets-Hagberg A-L, Goldschmidt TJ, Stålhandske T, Larsson-Sciard E-L. Amelioration of intrathymic T cell development and peripheral T cell reactivities in autoimmune mice undergoing therapy with a novel immunomodulator. Int Immunol 1990;2:645-50.
9. Karussis DM, Lehmann D, Slavin S et al. Successful treatment of chronic-relapsing experimental autoimmune encephalomyelitis with the synthetic immunomodulator Linomide (quinoline-3-carboxamide). Proc Natl Acad Sci 1993;90:6400-4.
10. Gross DJ, Sidi H, Weiss L, Kalland T, Rosenmann E, Slavin S. Prevention of diabetes mellitus in non-obese diabetic mice by Linomide, a novel immunomodulating drug. Diabetologia 1994;37:1195-201.
11. Vukanovic J, Hartley-Asp B, Isaacs JT. Inhibition of tumor angiogenesis and the therapeutic ability of Linomide against rat prostatic cancers. Prostate 1995;26:235-46.
12. Martin SJ, Reutelingsperger CPM, McGahon AJ. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J Exp Med 1995;182:1545-56.
13. Gonzalo JA, Gonzáles-Garcia A, Kalland T, Hedlund G, Martinez-A C, Kroemer G. Linomide inhibits programmed cell death of peripheral T cells in vivo. Eur J Immunol 1994;24:48-52.
14. Gonzalo JA, Gonzales-Garcia A, Kalland T, Hedlund G, Martinez,-A C, Kroemer G. Linomide, a novel immunomodulator that prevents death in four models of septic shock. Eur J Immunol 1993;23:2372-4.
15. Karussis D, Meiner Z, Lehmann D et al. Treatment of secondary progressive multiple sclerosis with the immunomodulator Linomide: Results of a double-blind placebo-controlled study with monthly MRI evaluation. Neurology 1995;45:A417.
16. Agus DB, Surh CD, Sprent J. Reentry of T cells to the adult thymus is restricted to activated T cells. J Exp Med 1991;173:1039-46.
17. Khoury SJ, Gallon L, Chen W et al. Mechanisms of acquired thymic tolerance in experimental autoimmune encephalomyelitis: thymic dendritic-enriched cells induce specific peripheral T cell unresponsiveness in vivo. J Exp Med 1995;182:357-66.