Elecanacin, a novel new naphthoquinone from the bulb of Eleutherine americana

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 10, 1997, Pages 1714-1716

  Hara, Hidemitsu ^a   Maruyama, Naoki ^a   Yamashita, Shinsuke ^a   Hayashi, Yasuhisa ^e   Lee, Kuo Hsiung ^b   Bastow, Kenneth F ^b   Chairul, ^c   Marumoto, Ryuji ^d   Imakura, Yasuhiro ^a  

^a NARUTO UNIVERSITY OF EDUCATION   (Japan)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c INDONESIAN INSTITUTE OF SCIENCES   (Indonesia)

^d TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^e NONE

Author keywords

Anti HIV; Elecanacin; Eleutherine americana; Human topoisomerase II inhibitor; Iridaceae; Isoeleutherol

Indexed keywords

ANTIVIRUS AGENT; DNA TOPOISOMERASE (ATP HYDROLYSING); NAPHTHOQUINONE;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE; NUCLEAR MAGNETIC RESONANCE;

EID: 0030663957     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1714     Document Type: Article

References (4)

1. Chen Z., Huang H., Wang C., Li Y., Ding J., Sankawa U., Noguchi H., Iitaka Y., Chem. Pharm. Bull., 34, 2743-2746 (1986) and references cited therein.
2. The interproton distances (Å) were calculated using MM2 and MOPAC(PM3) parameters of CAChe (ver. 3.8).
3. 3) δ: 19.18 (q, 11-C), 56.43 (q, 10-C), 76.64 (d, 1-C), 106.33 (d, 7-C), 116.50 (d, 6-C), 117.54 (s, 8a-C), 123.67 (d, 5-C), 125.92 (s, 3a-C), 126.61 (d, 4-C), 127.94 (s, 9a-C), 137.24 (s, 4a-C), 149.20 (s, 9-C), 156.61 (s, 8-C), 170.55 (s, 3-C).
4. 50) ≥ 5.0 considered to be significant. Isoeleutherin (3): TI=6.07; isoeleutherol (10): TI=13.4