Clinical evaluation of a new formula of timolol maleate (WP-934 ophthalmic solution)

Japanese Journal of Ophthalmology

Volumn 41, Issue 4, 1997, Pages 244-250

  Yamamoto, Tetsuya ^a   Kitazawa, Yoshiaki ^b   Azuma, Ikuo ^b   Tsukahara, Shigeo ^b   Nakashima, Mitsuyoshi ^b  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NONE

Author keywords

Glaucoma; Intraocular pressure; Reversible thermo setting gel; Timolol maleate

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; TIMOLOL MALEATE; UNCLASSIFIED DRUG; WP 934;

ADULT; AGED; ALLERGIC CONJUNCTIVITIS; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CORNEA EROSION; DRY EYE; FEMALE; HUMAN; HYPEREMIA; INTRAOCULAR DRUG ADMINISTRATION; INTRAOCULAR HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, TOPICAL; ADRENERGIC BETA-ANTAGONISTS; ADULT; AGED; DRUG EVALUATION; FEMALE; FOLLOW-UP STUDIES; GELS; GLAUCOMA, OPEN-ANGLE; HUMANS; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; OCULAR HYPERTENSION; OPHTHALMIC SOLUTIONS; PROSPECTIVE STUDIES; TIMOLOL;

EID: 0030663895     PISSN: 00215155     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-5155(97)00045-2     Document Type: Article

References (11)

1. Laurence JK, Holder D, Vogel R, et al. A double-masked, placebo-controlled evaluation of timolol in a gel vehicle. J Glaucoma 1993;2:177-82.
2. Kondo Y, Kono Y, Okada K, et al. Novel timolol ophthalmic solution dissolved in reversible thermosetting gel: Safety and hypotensive effect in normal volunteers. Atarashii Ganka 1995;12:1289-93.
3. Kato T, Yokoyama M, Takahashi A. Melting temperatures of thermally reversible gels: IV. Methyl cellulose-water gels. Colloid Polymer Sci 1978;256:15-21.
4. Grant WM. Toxicology of the eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986.
5. Kitazawa Y, Tsukahara S, Azuma I, et al. Phase II study of WP-934 in the patients with primary open-angle glaucoma and ocular hypertension. Rinshoiyaku 1996;12:2663-82.
6. Kitazawa Y, Tsukahara S. Azuma I, et al. Clinical evaluation of WP-934 ophthalmic solution in primary open-angle glaucoma and ocular hypertension. Rinshoiyaku 1996;12:2683-701.
7. Greaves JL, Wilson CG, Rozier A, et al. Scintigraphic assessment of ophthalmic gelling vehicle in man and rabbit. Curr Eye Res 1990;9:415-20.
8. Steinert RF, Thomas JV, Boger WP III. Long-term drift and continued efficacy after multi-year timolol therapy. Arch Ophthalmol 1981;99:100-3.
9. Azuma I, Masuda K, Kitazawa Y, et al. Phase III double masked comparative study of UF-021 ophthalmic solution in primary open-angle glaucoma and ocular hypertension. Folia Ophthalmol Jpn 1992;43:1432-40.
10. Kitazawa Y, Azuma I, Araie M. Clinical evaluation of betaxolol hydrochloride in the treatment of primary open angle glaucoma and ocular hypertension: Multi-center double-masked study in comparison with timolol. Clin Eval 1989;17:243-74.
11. Shields MB. Textbook of glaucoma. 3rd ed. Baltimore: Williams & Wilkins, 1992.