Surfactant convertase action is not essential for surfactant film formation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 273, Issue 5 17-5, 1997, Pages

  Gross, N J ^a,b,d   Veldhuizen, R ^c   Possmayer, F ^c   Dhand, R ^a,b  

^a HINES VA HOSPITAL   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c UNIVERSITY OF WESTERN ONTARIO   (Canada)

^d NONE   (United States)

Author keywords

Surfactant conversion; Surfactant subtype

Indexed keywords

DYFLOS; ENZYME; LUNG SURFACTANT; MYELIN; SURFACTANT;

ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; FILM COATING; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SURFACE TENSION;

EID: 0030662692     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.1997.273.5.l907     Document Type: Article

References (18)

1. Baritussio, A., L. Bellina, R. Carraro, A. Rossi, and M. Enzi. Heterogeneity of alveolar surfactant in the rabbit: composition, morphology, and labeling of subfractions isolated by centrifugation of lung lavage. Eur. J. Clin. Invest. 14: 24-29, 1984.
2. Barr, R. F., G. Putz, and S. Hawgood. Reconstituted surfactant-rich tubular myelin does not convert to vesicular forms with in vitro cycling (Abstract). Pediatr. Res. 33: 317A, 1993.
3. Bartlett, G. R. Phosphorus assay in column chromatography. J. Biol. Chem. 234: 466-468, 1959.
4. Enhorning, G. Pulsating bubble technique for evaluating pulmonary surfactant. J. Appl. Physiol. 43: 198-203, 1977.
5. Folch, J., M. Lees, and G. G. Sloane-Stanley. A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 228: 497-509, 1957.
6. Goerke, J. Lung surfactant. Biochim. Biophys. Acta 344: 241-261, 1974.
7. Gross, N. J. Extracellular metabolism of pulmonary surfactant: role of a new serine protease. Annu. Rev. Physiol. 57: 135-150, 1995.
8. Gross, N. J., and K. R. Narine. Surfactant subtypes in mice: characterization and quantitation. J. Appl. Physiol. 66: 342-349, 1989.
9. Gross, N. J., and K. R. Narine. Surfactant subtypes in mice: metabolic relationships and conversion in vitro. J. Appl. Physiol. 67: 414-421, 1989.
10. Gross, N. J., and R. M. Schultz. Serine proteinase requirement for the extra-cellular metabolism of pulmonary surfactant. Biochim. Biophys. Acta 1044: 222-230, 1990.
11. Gross, N. J., and R. M. Schultz. Requirements for extracellular metabolism of pulmonary surfactant: tentative identification of a serine protease. Am. J. Physiol. 262 (Lung Cell. Mol. Physiol. 6): L446-L453, 1992.
12. Magoon, M. W., J. R. Wright, A. Baritussio, M. C. Williams, J. Goerke, and J. A. Clements. Subfractionation of lung surfactant: implications for metabolism and surface activity. Biochim. Biophys. Acta 750: 18-31, 1983.
13. Putnam, E., L. A. J. M. Creuwels, L. M. G. vanGolde, and H. P. Haagsman. Surface properties, morphology and protein composition of pulmonary surfactant subtypes. Biochem. J. 320: 599-605, 1996.
14. Sanders, R. L., R. J. Hassett, and A. E. Vatter. Isolation of lung lamellar bodies and their conversion to tubular myelin figures in vitro. Anat. Rec. 198: 485-501, 1980.
15. Suzuki, Y., Y. Fujita, and K. Kogishi. Reconstitution of tubular myelin from synthetic lipids and proteins associated with pig pulmonary surfactant. Am. Rev. Respir. Dis. 140: 75-81, 1989.
16. Wright, J. R. Clearance and recycling of pulmonary surfactant. Am. J. Physiol. 259 (Lung Cell. Mol. Physiol. 3): L1-L12, 1990.
17. Wright, J. R., and J. A. Clements. Metabolism and turnover of lung surfactant. Am. Rev. Respir. Dis. 136: 426-444, 1987.
18. Wright, J. R., R. E. Wager, R. L. Hamilton, M. Huang, and J. A. Clements. Uptake of lung surfactant subfractions into lamellar bodies of adult rat lungs. J. Appl. Physiol. 60: 817-825, 1986.